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Re: Neratinib Trial 09
Has anyone discussed the mechanism of action with their oncologist and how this may impact, positively or negatively, the outcome with this drug? My understanding is that Herceptin and Tykerb are reversible Her2 inhibitors, neratinib is irreversible. So, what does this mean for the patient? Also, the interaction between Her2-Her3 appears to be the key to this disease. Does neratinib have any effects on this? I plan to discuss with my onc today but would love to compare notes with the group. Thanks!
Sue
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