anastrazole associated with increased body weight without increased food intake...

[Lani]

in rats! other side effect was osteoporosis, but prevented uterine cancer.(anastrazole is an AI)

Neoplasma. 2009;56(2):124-9.

Side effects of anastrozole in the experimental pre-menopausal mammary carcinogenesis.

Sadlonova V, Kubatka P, Kajo K, Ostatnikova D, Nosalova G, Adamicova K, Sadlonova J.
The aim of this study was to assess side effects of aromatase inhibitor anastrozole in the prevention of N-methyl-N-nitrosourea - induced pre-menopausal mammary carcinogenesis in female Sprague-Dawley rats. This model mimicked situation in healthy, but from the point of view of the development of breast cancer, high-risk pre-menopausal women. <p align="justify">Aromatase inhibitor anastrozole was used as a chemopreventive agent taken by the animals in the food during the whole period of time of the experiment. Group 1 - the control group had taken food without anastrozole, the groups 2 and 3 with anastrozole in various concentrations - 0.05 mg/1 kg of food (ANA 0.05) and 0.5 mg/1 kg of food (ANA 0.5). </p><p align="justify">In anastrozole-treated animals in comparison with untreated animals, macroscopic changes of uterus and vagina were not found. The values of absolute and relative wet weight of uterus and vagina in the groups ANA 0.05 and ANA 0.5 were comparable with the control. Histological examination did not show atrophic changes in endometrium of uterus and in epithelium of vagina in anastrozole-treated animals. In the group ANA 0.5 myometrium was significantly grosser than in the group ANA 0.05 (P<0.05). Anastrozole neither affects parameters of plasma lipid metabolism (triacylglycerols, total cholesterol, low - density lipoprotein cholesterol and high - density lipoprotein cholesterol) nor serum levels of sex hormones (estradiol, testosterone, dehydroepiandrosterone). Compact bone thickness in the groups with anastrozole was significantly increased in comparison with untreated animals (P<0.001). A significant increase in body weight was found in the group ANA 0.5 compared with the control group (P<0.01). The significant increase in body weight gain was not attended by the significant increase in food intake.</p><p align="justify">The side effects of aromatase inhibitor anastrozole in the prevention of N-methyl-N-nitrosourea - induced pre-menopausal mammary carcinogenesis in female Sprague-Dawley rats on myometrium, compact bone thickness and body weight gain were observed. </p> Keywords: pre-menopausal mammary carcinogenesis, chemoprevention, aromatase inhibitors, anastrozole, side effects, female rats.
PMID: 19239326

[Donna]

Do you think this would apply to Femara as well? I am having a terrible time trying to lose weight I gained during chemo. I would like to know if maybe it isn't all my fault, but some credit could go to Femara.

:-)

Donna

VALIDATION!!!!!! I have been working out and watching my diet and once again the weight is piling back on....
Thought I was NUTS!

[Becky]

When does the problem begin to occur? From the get go or over time?

[Donna]

Hi all, found this, thought it was worth posting:

Obesity continues to rise in the United States and throughout the world. Both leptin from fat cells and insulin from pancreatic B cells are created in direct proportion to body fat. Obese persons have higher levels of these two hormones than lean individuals. Recent studies show that another hormone, estrogen, also has a similar affect. When estrogen receptors in the hypothalamus of rats were destroyed, female rats ate more food, burnt less energy and became obese. Research suggests a link between estrogen and obesity, especially the dangerous accumulation of abdominal fat linked to cardiovascular disease, type-2 diabetes mellitus, and certain cancers. The abstract was submitted by Deborah J. Clegg, PhD, Assistant Professor of Psychiatry, Obesity Research Center, at the University of Cincinnati Academic Health Center, to the 234th national meeting of the American Chemical Society on August 20, 2007. Her findings will assist scientists in developing new hormone replacement therapies.

[Lien]

I've always been very thin, but now with 4 yrs of arimidex I've gained a couple of kilo's. I have to watch what I eat now. I think the weight gain began pretty soon after I started taking arimidex. Wonder if it will get better when I stop taking it.

Jacqueline