HonCode

Go Back   HER2 Support Group Forums > Clinical Trials
Register Gallery FAQ Members List Calendar Search Today's Posts Mark Forums Read

Reply
 
Thread Tools Display Modes
Old 10-26-2008, 02:03 PM   #1
eric
Senior Member
 
Join Date: Sep 2005
Posts: 589
positive data from a Phase I clinical trial of carfilzomib

http://www.redorbit.com/news/health/...ource=r_health
Proteolix Reports Encouraging Results From Phase I Cancer Trial

Posted on: Sunday, 26 October 2008, 09:00 CDT
Proteolix has reported positive data from a Phase I clinical trial of carfilzomib in patients with advanced solid tumors.
The Phase I clinical trial was designed to assess the safety, pharmacokinetics and pharmacodynamics of carfilzomib among patients with advanced solid tumors who had previously failed at least two rounds of prior treatment with approved chemotherapies.
Patients received carfilzomib administered for two consecutive days for each of the first three weeks on a four-week cycle. Dosing commenced at 20mg/m2 and escalated thereafter to a dose of 36mg/m2.


A total of 14 patients were enrolled in the study. Of those, one renal cell patient who had previously failed three prior rounds of treatment achieved a partial response and remains on the study after eight months of treatment. One small cell lung cancer patient achieved stable disease and is continuing on study after six months, and a mesothelioma patient achieved stable disease for five months. Carfilzomib was generally well tolerated with a low incidence of grade three or higher adverse events.
Lori Kunkel, chief medical officer of Proteolix, said: "We believe carfilzomib exhibits strong potential in diverse cancer indications. Based on these encouraging results, we recently initiated a Phase II clinical trial evaluating carfilzomib's activity in four types of solid tumor cancers. In addition, we look forward to reporting data from our ongoing trials of carfilzomib in hematologic malignancies later this year."
eric is offline   Reply With Quote
Old 11-01-2008, 07:35 PM   #2
Jackie07
Senior Member
 
Jackie07's Avatar
 
Join Date: Jan 2008
Location: "Love never fails."
Posts: 5,801
"Novel proteasome inhibitor; also being evaluated in a Phase I trial in combination with Revlimid-dex."

Carfilzomib is a structurally- and mechanistically-novel proteasome inhibitor that exhibits a high level of selectivity for a single active site in the proteasome with minimal cross reactivity to other protease classes. In addition to the ongoing clinical trials in multiple myeloma, Proteolix is evaluating carfilzomib as a single agent in a Phase 2 trial of patients with advanced solid tumors and in a Phase 1 study of lymphoma. Phase 1 clinical studies have shown that patients with hematologic malignancies who have relapsed or progressed following multiple therapies can achieve durable anti-tumor responses with carfilzomib.
__________________
Jackie07
http://www.kevinmd.com/blog/2011/06/doctors-letter-patient-newly-diagnosed-cancer.html
http://www.asco.org/ASCOv2/MultiMedi...=114&trackID=2

NICU 4.4 LB
Erythema Nodosum 85
Life-long Central Neurocytoma 4x5x6.5 cm 23 hrs 62090 semi-coma 10 d PT OT ST 30 d
3 Infertility tmts 99 > 3 u. fibroids > Pills
CN 3 GKRS 52301
IDC 1.2 cm Her2 +++ ER 5% R. Lmptmy SLNB+1 71703 6 FEC 33 R Tamoxifen
Recc IIB 2.5 cm Bi-L Mast 61407 2/9 nds PET
6 TCH Cellulitis - Lymphedema - compression sleeve & glove
H w x 4 MUGA 51 D, J 49 M
Diastasis recti
Tamoxifen B. scan
Irrtbl bowel 1'09
Colonoscopy 313
BRCA1 V1247I
hptc hemangioma
Vertigo
GI - > yogurt
hysterectomy/oophorectomy 011410
Exemestane 25 mg tab 102912 ~ 101016 stopped due to r. hip/l.thigh pain after long walk
DEXA 1/13
1-2016 lesions in liver largest 9mm & 1.3 cm onco. says not cancer.
3-11 Appendectomy - visually O.K., a lot of puss. Final path result - not cancer.
Start Vitamin D3 and Calcium supplement (600mg x2)
10-10 Stopped Exemestane due to r. hip/l.thigh pain OKed by Onco 11-08-2016

"I WANT TO BE AN OUTRAGEOUS OLD WOMAN WHO NEVER GETS CALLED AN OLD LADY. I WANT TO GET SHARP EDGED & EARTH COLORED, TILL I FADE AWAY FROM PURE JOY." Irene from Tampa

Advocacy is a passion .. not a pastime - Joe

Last edited by Jackie07; 11-01-2008 at 07:45 PM..
Jackie07 is offline   Reply With Quote
Reply

Thread Tools
Display Modes

Posting Rules
You may not post new threads
You may not post replies
You may not post attachments
You may not edit your posts

BB code is On
Smilies are On
[IMG] code is On
HTML code is Off

Forum Jump


All times are GMT -7. The time now is 02:56 PM.


Powered by vBulletin® Version 3.8.7
Copyright ©2000 - 2018, vBulletin Solutions, Inc.
Copyright HER2 Support Group 2007
free webpage hit counter