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SOFT trial
arimidex.com
femara.com
Aromasin.com
Armidex is Anastrozole
Femeara is Letrozole
Aromasin is Exemestane
As you can see Armidex & Femeara both end in Zole. This means they basically have the same chemical makeup but are manufactured by different companies; However Aromasin is different.
All of these drugs are for use for POST menopausal women. The standard treatment for pre menopausal women is still Tamoxifen. If you are pre menopausal you could talk to your ONC about ovarian suppression or join the SOFT trial. They are still looking for participants. They hope to get 3000 for the trial. I signed up this week.
The SOFT trial is Suppression of Ovarian Function Trial (SOFT). The SOFT trial has three arms. One is Tamoxifen alone (which is the standard treatment used today for pre menopausal women); the second is Tamoxifen plus ovarian suppression and the last is an experimental arm with a post menopausal drug called Exemestane plus ovarian suppression. The ovarian suppression can be done by surgery, radiation or a monthly shot of Triptorelin. For pre menopausal women with estrogen positive breast cancer, it is important to block the estrogen, but AIs are not strong enough to block the estrogen in pre menopausal women. The estrogen in pre menopausal women is produced by the ovaries so shutting them down may be the right course of action. This trial is designed to test if the more aggressive approach will prevent reoccurrences and survival rates.
The arm I was randomized to is Tamoxifen alone. <O 
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DX 11/14/05, Stage 1C, Her2+ 3.4, ER+, PR+, K167 23%, Node Negative, MX0, Grade 3, 1.8CM, Lumpectomy 12/7/05; 6 rounds dense dose Taxol bi-weekly, 35 radiation, 1 year Herceptin, & Tamoxifen ongoing.
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Hybrid Mode
