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Old 10-07-2006, 11:12 AM   #1
RobinP
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I don't know, you know, nano has to be very small. I mean less than .2mm is nano, I think, and .02cm to 2cm is micro, I think. Anyway, the implications of the article, is even the tiniest thing is a bad thing when its in the node. Ug, oh no.
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Old 10-07-2006, 12:09 PM   #2
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RobinP, something I have wondered for quite a while is how accurate some of the nodal classifications are that go back before "breadloafing" and IHC staining of the nodes became common (which I guess is when Sentinel Node biopsies became standard care). Makes me think that there were more than a few "node positives" lumped in with the "node negative" stats. Maybe true node negatives have a better recurrence rate? Who knows, just call me . . . . .


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Old 10-08-2006, 07:14 AM   #3
RobinP
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Well, Hope amazing what technology brings, sometimes things maybe you rather not know, but then again better that you do know for best treatment. I'm one of those that was positive node by IHC only, not H&E. Anyway, about 30% of node negative by traditional standards of H&E were found to relaspe, probably most of them would be node positive by newer IHC testing.

Hopeful, I like that name. Just keep posting, we need a lot of that around here you know..."Hopeful". Take care...
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Old 10-08-2006, 11:09 AM   #4
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I stained 2 micromets to my sentinel node (both were less than 1.8 mm). At my surgery, my surgeon said I was lucky to be node negative but at Sloane - they said "whoa Nellie" and discovered 2 tiny mets to the sentinel. So... depressingly, I ended up with one node involved. Thankfully so however because I got AC followed by Taxol and had no problem getting Herceptin too. I think if I didn't have the node involved (or it was but not discovered), I would have had 4 AC (since the tumor was over 1cm) but that would have been it. So I think in the long run, it worked out since 2 spots is not as bad as a loaded node and it really had to be looked for.


So, I always say that besides a second medical opinion, one should always get the slides looked at by another pathologist as well.

Have a nice weekend

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Old 10-08-2006, 05:53 PM   #5
RobinP
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Becky, how are ya, probably on the chat now, ah? Well, anyway I agree on multiple medical opinions, perhaps more than two. Here's why. A certain major NY City cancer center, that I am not suppose to disclose due to a legal payoff to me for their mistake, misdiagnosed me on my second pathology opinion.

I had a lumpectomy locally where only DCIS was found. Then the major cancer center did a second opinion and agreed it was only DCIS. Then I had a mastecomty with sentinel due to large size of DCIS. That's when the micro met node was found and they didn't know what to make of it for prognosis, particulary since I had only DCIS. Then they said do CMF for six month, just to be safe. Anyway, after I was done CMF, I had the lumpectomy slides checked since I finally noticed that my pathologist at the major cancer center was not "breast pathologist but anotomical". So I had their " breast pathologist" check the slides for a third time and that's when the freaking invasive 4mm her2+ bc was found. And the orginal pathologist at the major cancer center was required to admend his records. In other words, he agreed he made an error. Scary story, isn't it from a major cancer center?
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Old 10-08-2006, 06:06 PM   #6
tousled1
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Robin

Hopefully, with newer diagnostics available there will be fewer misdiagnosis made. In my case I don't have to worry about the nano or micro mets in the lymph nodes. There was definitely no doubt about my lymph nodes.
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Kate
Stage IIIC Diagnosed Oct 25, 2005 (age 58)
ER/PR-, HER2+++, grade 3, Ploidy/DNA index: Aneuploid/1.61, S-phase: 24.2%
Neoadjunct chemo: 4 A/C; 4 Taxatore
Bilateral mastectomy June 8, 2006
14 of 26 nodes positive
Herceptin June 22, 2006 - April 20, 2007
Radiation (X35) July 24-September 11, 2006
BRCA1/BRCA2 negative
Stage IV lung mets July 13, 2007 - TCH
Single brain met - August 6, 2007 -CyberKnife
Oct 2007 - clear brain MRI and lung mets shrinking.
March 2008 lung met progression, brain still clear - begin Tykerb/Xeloda/Ixempra
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Old 10-08-2006, 07:08 PM   #7
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Wow, Kate a lot of +nodes! God bless you girl. I just hope that the treatments kick this thing in the butt for you and you never have to deal with bc again. Take care...
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