http://cancerres.aacrjournals.org/cg...ull/63/21/7277
A Molecular Mechanism Regulating Circadian Expression of Vascular Endothelial Growth Factor in Tumor Cells1
In this article the important cancer growth factor VEGF is shown to be at higher levels in mice tumours screened during daylight time compaired to night time.
It also has been shown in other mice experiments that some anticancer drugs are more effective if given during daylight time.
Optimum temporal control of VEGF (for instance with antiangiogenesis treatments) may thus provide one explanation of the validity of chronotherapy.
Since mice are nocturnal animals the reverse temporal effect may be seen in humans for whom night time treatments of VEGF may sometimes in the future be proven to be more effective (if the treatment drug has to be administered at least once a day).
Among the candidates for this type of chronotherapy are the chemo drugs (such as
Cyclophosphamide) taken as a daily low dose pill in so called metronomic treatments where their antiangiogenesis properties are exploited as opposed to their cytotoxic properties in high dose regimens.
For instance in this clinical trial on ovarian cancer using daily Cyclophosphamide pills & weekly Avastin I.V.'s (an other antiangiogenesis drug), one can speculate that if the pills had been taken at night the outcomes might have been even better.
http://www.csmc.edu/pdf/WCRI-ASCO-Av...stin%20pill%22
TARGETED CANCER DRUG COMBINED WITH A PILL FORM OF LOW-DOSE
CHEMOTHERAPY FOUND TO SHRINK TUMORS AND SLOW PROGRESSION OFRECURRENT OVARIAN CANCER
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