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Hi,
I've been taking Tykerb with Avastin and Gemzar since early July. My scans at the end of August showed liver mets had shrunk by 30% so we are continuing. I too had lots of GI problems on Tykerb and Xeloda. When I started back on Tykerb, Avastin and Gemzar I was still having some bloating and gas, so I am on a slightly reduced dose (4 pills daily instead of 5). It has reduced my GI symptoms (only occassional diahhrea) and is working well. So there are many options with Tykerb if your onc is willing to be creative.
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Donna
Diagnosed 2/04 - Invasive ductal - no clean margins
node negative - er+pr+, her2++
Mastectomy 4/04 - 4 rounds AC
9/05 - mets to liver treated with carbo/ixabipelone/herceptin
3/06 - complete remission
9/06 - new liver mets, starting Taxotere/Herceptin
1/07 -Liver mets stable, staying on Herceptin
5/07 - Liver, lung progression - starting T/X
12/07 - Liver, lung progression - starting weekly Navilbene/Herceptin
4/08 - Liver progression - started Abraxane, Carbo, Tykerb and Herceptin
7/08 - Liver Progression - started Gemzar, Avastin and Tykerb
10/08 - Liver progression - starting Doxil
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