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[phil]

Lorraine got into the original t dm-1 eap in 2010, w/ an extensive hx pf pre-treatment w/ all kinds of drugs, incl. a lot of adria , an anthracycline . in fact, she was txed w./ adria alone the last few weeks to get her into the eap, to keep her liver counts w/in eap limits. part of the argument to get her in was that since she was close to life-time limits on anthracyclines she would have to stop them soon anyway, then what ??
eap criteria in 2010 primarly focused on having progressed on her2 therapy, taxanes and tykerb. so i think some exposure to anthracyclines is very common in many t dm-1 candidates at this point