Johns Hopkins is viewing cell behavior in three dimensions (3D)

[gdpawel]

The evolutionary nature of cancer implies that the required target for the consistent and specific cure or control of cancer is the set of all malignant cells that could evolve. Targeting a lesser set will fail. It will act as a selective pressure that changes the course, but not the flow of tumor cell evolution.

The consistent and specific cure or control of cancer will require developing a set of drugs, given in combination, targeted to patterns of normal cellular machinery related to proliferation and invasiveness.

A sufficient number of independent methods of cell killing must be employed so that it is too improbable for a cancer cell to evolve that can escape death or inactivation. It must examine every cell in the body and must do so for a prolonged period of time.