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Old 10-03-2007, 03:00 PM   #1
julierene
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Join Date: Dec 2005
Location: Illinois
Posts: 327
Question Months Time to Progression

Study Results
Women taking lapatinib plus chemotherapy benefited more overall than women taking a placebo plus chemotherapy. Median progression-free survival, or the time women went without their cancer growing, was 7.9 months for the combination group, compared to 5.2 months for the group that took chemotherapy alone.
Women in the combination group responded to treatment for a median of 7.4 months, compared to 5.5 months for the placebo group. In the combination group, treatment lessened the presence of disease in 60 percent of women, compared to 36 percent in the placebo group.

http://www.lbbc.org/content/news/com...y&auid=3059530

Does this trouble anyone else? I am on this treatment for 2 months extra? It seems almost worthless in how it is presented - to even be on this treatment. Ugh! I'm taking Tykerb and Xeloda, but shesh.... Is this what I have to look forward to? 2 more extra months?

Then you see this:

In a study of 321 women, all with advanced breast cancer who tested positive for HER2, 160 who received Tykerb with Xeloda had no cancer growth for 36.9 weeks. The other 161 women who were on Xeloda alone experienced no cancer growth for just 19.7 weeks. The trial was stopped so that the women who were not taking Tykerb could do so if they wished.

http://www.medicalnewstoday.com/articles/44505.php

Which way is it?
__________________
Jan04: Bilateral Mastectomy at age 28
Initial DX: Left Breast: IDC 2cm, Grade 3, HER2+3, 0 Nodes +, ER/PR-. Right Breast: Extensive DCIS ER-/PR+; Stage 1-2a
Feb04-Apr04: 4 AC, dose dense
Aug 04: 4 Taxotere
Dec 05: Bone and Liver METS; Stage 4. Carboplatin/Taxol/Herceptin. DX with Li-Fraumeni Syndrome
Apr 06: NED, maintenance Herceptin
Apr 07: CA1503=14; masses in liver; Xeloda/Tykerb
Nov 07: NED, Tykerb maintenance
Sept 08: Liver mets again, on Tykerb/Xeloda again, CA=19 and 27
Nov 08: Progression, Tykerb/Gemzar, CA=25
Dec 08: Progression, Herceptin/Navelbine, CA=40, 57, and 130
Jan 09: Progression in bone, recession in liver, Herceptin/Carbo/Abraxane CA=135
June 09: CA27/29=24, chemo break
Sept 09: Progression, CA=24, waiting on clinical trial (4 weeks no treatment)
Nov 09: now have brain mets, trial "on hold", getting 14 WBR treatments starting 11/2/09
Dec 09: possible start on p53 trial
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