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Old 10-19-2008, 10:22 PM   #1
Lida
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Join Date: Oct 2007
Posts: 57
Herceptin/Gemzar- HIGH RISING LIV. ENZYMES! HELP!

Hi friends,
I recently had to start a new chemo, Herceptin/Gemzar and had an unpleasant surprise! After one week of treatment, liver enzymes skyrocket!!! ALT went from 40 to 213 and AST went from 49 to 175!! ALK from 123 to 180. My liver enzymes never moved that much (or even close to) or that high though I have liv. mets and had other chemos! This is new and very scary. Hearing from you may bring me some peace of mind. Lida
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Old 10-20-2008, 12:25 PM   #2
doh2pa
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Join Date: Oct 2005
Location: Chadds Ford, Pa
Posts: 206
Hi Lida,

My liver enzymes also rose on Gemzar. My onc warned that the rise is a common side effect. I'm sure your doctor will regularly monitor this, so if he/she is not concerned then follow their lead.
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Donna
Diagnosed 2/04 - Invasive ductal - no clean margins
node negative - er+pr+, her2++
Mastectomy 4/04 - 4 rounds AC
9/05 - mets to liver treated with carbo/ixabipelone/herceptin
3/06 - complete remission
9/06 - new liver mets, starting Taxotere/Herceptin
1/07 -Liver mets stable, staying on Herceptin
5/07 - Liver, lung progression - starting T/X
12/07 - Liver, lung progression - starting weekly Navilbene/Herceptin
4/08 - Liver progression - started Abraxane, Carbo, Tykerb and Herceptin
7/08 - Liver Progression - started Gemzar, Avastin and Tykerb
10/08 - Liver progression - starting Doxil
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