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01-24-2008, 10:42 PM
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#1
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Senior Member
Join Date: May 2006
Location: California
Posts: 668
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Need Help, please
Hi everyone: I had an appointment with my onc 1-22-08, here's the scoop.
Last ct chest scan shows tumor is growing so a change in treatment is necessary since I have been on navelbine twice and it has finally lost its effectiveness.
Onc said that since am doing well and I feel great that he's hesitant to put me on a taxane. He mentioned neurophaty, hair loss..bla bla bla..
My situation is unique to him since mets to rt lung since 2003 has been localized only to that area. I do feel great but I know I need to keep this monster under control...As far has hair goes I do not care if I loose my hair again..I just want to be here for my husband and daughter, bald or not.
Onc said that he was going to meet with his colleagues and present my case to them before making a decision to whether put me on a chemo or radiate the lung. Onc has never treated anyone with my condition with radiation...he did mention that people with lung ca do get radiation in their lungs and some get to be NED for long periods of time, but that's not my case, since I do not have lung ca.
DO you know anyone with mets who's received radiation and has done well?.
I do not want to receive radiation unless there is proof that it's going to work. Other thing the onc mentioned is whether to continue with herceptin along with radiation, or discontinue herceptin during radiation.
I have an appointment before February 19th and will need to make a decision then. Even though I still do not have information regarding his meeting with his colleagues, I would like to know if anyone in this site has known anyone who successfully has gone through radiation and/or would like an opinion regarding this situation.
Please I need all the help you can provide me with. Thank you so much.
__________________
1994 - rt brst, .lump, underarm node dissection,chemo+rad 1.2 cms, Grade 3.
28 nodes neg
Er,Pr, Positive HER2 status unknown
2003- Recur to rt lung.July 16 ( B-Day!)
Her2+++ Er,Pr, Negative
2003 - Aug04--Navelbine + Herceptin
2004- 2007--NED - Herceptin, only
2007 Feb-April Xeloda added to hereceptin
2007-May Back on Navelbine+Herceptin
2008-Feb-Mar 15 Ses Rad to Rt. Lung
2008- Oc 17 Add Tykerb to Herceptin
2009- June-- Discont Tykerb
2009 July 7--Current Taxol + Herceptin
2009 Dec--Discontinued treatment due to progression. Looking into cyberknife.
2010-Aug Accepted to TDM1, no SE, except liver count went up.
2010-2011 September got kicked out of the trial, due to a small spot found on lung.
2011- 2012 September thru early 2013 on Herceptin
2013- March Bone density shows small spot on 5th rib.
2013 - April 4th appt with onc. will post after discussing course of treatment.
2013-March-April Cyber knife to brain and radiation to rib. Chest --base line before chemo-CT-Scan stable for lung issue. CA2729 Normal.
2013 April Herceptin- TDMI
2013 Sept Herceptin + Perjeta . CA2729 within normal range. Brain and Pet scans October 31st. will post results.
2013 October Brain MRI- mixed response. Will see Onc/rad on Halloween.
2013 October/November Brain-MRI nothing new. Repeat MRI next year in May.
2013 December Continue Herceptin and Perjeta. Stable at the moment.
2014 February Brain MRI -clear!
2014 January Added Taxotere to Perjeta+Herceptin.
2014 March Stopped chemo-chest ct-scan next.
2014- March Scans shows tumor's larger, CA2729 higher. Discontinue Herceptin.
2014 April Perjeta+ Halaven
2014 April CA2729 went down 60 points after one cycle. Cough does not want to go away.
2014 June Continue on Perjeta + Halaven-- no more cough. Stable
2014 June Back on Herceptin + abraxane
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01-25-2008, 03:01 AM
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#2
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Senior Member
Join Date: Oct 2005
Location: New Jersey
Posts: 3,154
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Hi Adriana,
I do not have first hand knowledge in radiation and herceptin.
But I did some research for you and found the following aritcle
which I have linked for your review.
Since your lung met is on your right side, the article reports that
it is safer for your heart to receive radiation on the right side and
newer radiation machines provide safer treatments. If you do decide
to have treatment with radiaiton MAKE sure the facility has current
and updated equipment.
http://www.medicalnewstoday.com/articles/49733.php
Will keep researching and post anything I find.
All good wishes,
Jean
__________________
Stage 1, Grade 1, 3/30/05
Lumpectomy 4/15/05 - 6MM IDC
Node Neg. (Sentinel node)
ER+ 90% / PR-, Her2+++ by FISH
Ki-67 40%
Arimidex 5/05
Radiation 32 trt, 5/30/05
Oncotype DX test 4/17/06, 31% high risk
TOPO 11 neg. 4/06
Stopped Arimidex 5/06
TCH 5/06, 6 treatments
Herceptin 5/06 - for 1 yr.
9/06 Completed chemo
Started Femara Sept. 2006
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01-25-2008, 03:38 AM
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#3
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Senior Member
Join Date: Oct 2005
Location: New Jersey
Posts: 3,154
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Adriana,
a short article on herceptin and radiation.
http://isopp.org/tiki-print_article.php?articleId=407
Jean
__________________
Stage 1, Grade 1, 3/30/05
Lumpectomy 4/15/05 - 6MM IDC
Node Neg. (Sentinel node)
ER+ 90% / PR-, Her2+++ by FISH
Ki-67 40%
Arimidex 5/05
Radiation 32 trt, 5/30/05
Oncotype DX test 4/17/06, 31% high risk
TOPO 11 neg. 4/06
Stopped Arimidex 5/06
TCH 5/06, 6 treatments
Herceptin 5/06 - for 1 yr.
9/06 Completed chemo
Started Femara Sept. 2006
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01-25-2008, 05:39 AM
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#4
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Senior Member
Join Date: Aug 2003
Location: Morris, IL
Posts: 3,507
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Adriana
Any chance on getting an appointment to see Dr. Slamon there in California and get his opinion? His is one I would want if I was looking for a second opinion...I think Jean went to him....I think he would give great insight.....wishing you a good response with whatever treatment gets the go...there are still many for you out there. By the way, I have been on Taxol for 8 months and except for the hair loss and a few nosebleeds, I have done well...I am just starting to get the leg neuropathy...seems worse the first couple days after treatment.
By the way, how is your husband doing? He is in my prayers every day.
__________________
"Be kinder than necessary, for everyone you meet is fighting some kind of battle."
Hugs & Blessings
Sheila
Diagnosed at age 49.99999 2/21/2002 via Mammography (Calcifications)
Core Biopsy 2/22/02
L. Mastectomy 2/25/2002
Stage 1, 0.7cm IDC, Node Neg from 19 nodes Her2+++ ER PR Neg
6/2003 Reconstruction W/ Tissue Expander, Silicone Implant
9/2003 Stage IV with Mets to Supraclavicular nodes
9/2003 Began Herceptin every 3 weeks
3/2006 Xeloda 2500mg/Herceptin for recurrence to neck nodes
3/2007 Added back the Xeloda with Herceptin for continued mets to nodes
5/2007 Taken Off Xeloda, no longer working
6/14/07 Taxol/Herceptin/Avastin
3/26 - 5/28/08 Taxol Holiday Whopeeeeeeeee
5/29 2008 Back on Taxol w Herceptin q 2 weeks
4/2009 Progression on Taxol & Paralyzed L Vocal Cord from Nodes Pressing on Nerve
5/2009 Begin Rx with Navelbine/Herceptin
11/09 Progression on Navelbine
Fought for and started Tykerb/Herceptin...nodes are melting!!!!!
2/2010 Back to Avastin/Herceptin
5/2010 Switched to Metronomic Chemo with Herceptin...Cytoxan and Methotrexate
Pericardial Window Surgery to Drain Pericardial Effusion
7/2010 Back to walking a mile a day...YEAH!!!!
9/2010 Nodes are back with a vengence in neck
Qualified for TDM-1 EAP
10/6/10 Begin my miracle drug, TDM-1
Mixed response, shrinking internal nodes, progression skin mets after 3 treatments
12/6/10 Started Halaven (Eribulen) /Herceptin excellent results in 2 treatments
2/2011 I CELEBRATE my 9 YEAR MARK!!!!!!!!!!!!!
7/5/11 begin Gemzar /Herceptin for node progression
2/8/2012 Gemzar stopped, Continue Herceptin
2/20/2012 Begin Tomo Radiation to Neck Nodes
2/21/2012 I CELEBRATE 10 YEARS
5/12/2012 BeganTaxotere/ Herceptin is my next miracle for new node progression
6/28/12 Stopped Taxotere due to pregression, Started Perjeta/Herceptin
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01-30-2008, 05:05 PM
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#5
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Senior Member
Join Date: May 2006
Location: California
Posts: 668
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Hi from Adriana
Dear Sheila:
Thank you for asking about my husband. He's still at the rehab facility, he's doing a lot better, talks a lot more, walks little more than before-with help- he's able to get in and out of the car with little help.
He goes to the bathroom with assistance also. He's alert and understands everything. He gets frustrated because he cannot communicate but doc put him on an antidepressant and it has helped him a lot.
Doc said that it will take at least a year before is able to walk again, but he will regain the use of his legs and speech.
He's seeing a neuro-biofeedback doc and also a chiropractor. Both are helping him. Husband likes both of them.
Thank you so much for responding to my email. I have not made a decision as of yet. I have a little more time......:-) Stay well.
Much love to you.
__________________
1994 - rt brst, .lump, underarm node dissection,chemo+rad 1.2 cms, Grade 3.
28 nodes neg
Er,Pr, Positive HER2 status unknown
2003- Recur to rt lung.July 16 ( B-Day!)
Her2+++ Er,Pr, Negative
2003 - Aug04--Navelbine + Herceptin
2004- 2007--NED - Herceptin, only
2007 Feb-April Xeloda added to hereceptin
2007-May Back on Navelbine+Herceptin
2008-Feb-Mar 15 Ses Rad to Rt. Lung
2008- Oc 17 Add Tykerb to Herceptin
2009- June-- Discont Tykerb
2009 July 7--Current Taxol + Herceptin
2009 Dec--Discontinued treatment due to progression. Looking into cyberknife.
2010-Aug Accepted to TDM1, no SE, except liver count went up.
2010-2011 September got kicked out of the trial, due to a small spot found on lung.
2011- 2012 September thru early 2013 on Herceptin
2013- March Bone density shows small spot on 5th rib.
2013 - April 4th appt with onc. will post after discussing course of treatment.
2013-March-April Cyber knife to brain and radiation to rib. Chest --base line before chemo-CT-Scan stable for lung issue. CA2729 Normal.
2013 April Herceptin- TDMI
2013 Sept Herceptin + Perjeta . CA2729 within normal range. Brain and Pet scans October 31st. will post results.
2013 October Brain MRI- mixed response. Will see Onc/rad on Halloween.
2013 October/November Brain-MRI nothing new. Repeat MRI next year in May.
2013 December Continue Herceptin and Perjeta. Stable at the moment.
2014 February Brain MRI -clear!
2014 January Added Taxotere to Perjeta+Herceptin.
2014 March Stopped chemo-chest ct-scan next.
2014- March Scans shows tumor's larger, CA2729 higher. Discontinue Herceptin.
2014 April Perjeta+ Halaven
2014 April CA2729 went down 60 points after one cycle. Cough does not want to go away.
2014 June Continue on Perjeta + Halaven-- no more cough. Stable
2014 June Back on Herceptin + abraxane
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01-25-2008, 03:08 AM
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#6
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Senior Member
Join Date: Oct 2006
Location: I live in Christmas, MI - located on the shores of Lake Superior.
Posts: 606
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I can't tell you what to do, but my doc in Chicago said that they do not usually do radiation to a met to the lung unless it makes you uncomfortable. I do not know if this is the standard. I also know that you usually sign a waiver at the radiologists that says they do not guarantee it will work. Whatever decision you make I wish you luck. Abraxane and Tykerb has wiped out my lung met and nodes in my chest as well as bone mets. If you read my signature you will see that they tried several things before this and it never went totally away before. I just hope this lasts! That is the unknown at this point.
I hope you get really great recommendations and that they work. Please keep us updated, I will be sending positive thoughts your way and keeping an eye out for your posts!
__________________
Barb
10/03 Radical Mastectomy 3 cm tumor - 1/17 Nodes Stage II B, Her 2 +++ ER-/PR- 11/03 4 AC 4 Taxol 12/05 Stage IV - Lung met , Bone mets - Carbo, Taxotere, Herceptin 9/06 - 2 cm brain tumor 10/06 - Tumor removal surgery - Herceptin Halted 12/06 gamma knife tumor base.1/07 Navelbine/Herceptin 4/07 Rads to R femur 5/07 Stereotactic - new 2 cm brain tumor 4/07 Start Xeloda 5/07 Tykerb added 7/07 Brain MRI clean 10/07 .055 cm brain met found. 12/07 Stereotactic -1 cm brain tumor Start Tykerb 11/07 Abraxane/Herceptin 5/08 Cisplatin, Gemcitabine/Herceptin 6/08 Stereotactic to 1cm 9/08 Stereotactic repeat (growth). 11/08 Pet Scan Good but new tiny met on L lung/dead Brain surgery (no cancer cells found/scar tissue) 1/09 Chemo restarted 2/09 Pet Scan Bad - R larger very active/active L active lymph nodes both sides of chest MRI- mets slight increase 2/09 Start Doxil/Tykerb Treatment
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01-25-2008, 07:07 AM
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#7
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Senior Member
Join Date: Jun 2006
Location: San Antonio, TX
Posts: 2,357
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Adriana, you're already getting great ideas and suggestions, but I wanted to add my love and prayers for a good choice and outcome. ma
__________________
MA in TX.
Grateful for each and every day....
Diag. 12/05 at age 60
Stage II, Grade 3, 4.5 cm primary tumor
ER/PR- Her2 +3 strongly positive
Her2 by FISH 7.7 amplified
vascular invasion
Ki67 20% borderline
Jan - March '06 Taxotere/Adriamycin X 3 to try to shrink tumor - it grew
April '06 Rt Modified Radical Mas, 7 of 9 nodes positive
April - Aug. '06 Herceptin/Taxol/Carboplatin X 8 (dose dense)
Sept - Dec. '06 Navelbine/Herceptin x 8 (dose dense)
Radiation & Herceptin Jan. 22 - March 1, 2007
Finished Herceptin Dec. 10 '08! One extra year.
Port removed August, 2012.
8 1/2 years since diagnosis! 5 1/2 Years NED!
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01-25-2008, 07:17 AM
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#8
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Senior Member
Join Date: Jul 2006
Posts: 869
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Adriana, I have had one lung met-possibly two and have been on Xeloda-Navelbine and Herceptin with good results so far. My onc never mentioned radiation to the lung as an alternative...only surgery and chemo. Good Luck with this, I would be interested to know what you pursue....your fellow July 16th b-day gal. Ceesun
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01-25-2008, 08:31 AM
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#9
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Senior Member
Join Date: Feb 2006
Location: Acworth, GA
Posts: 2,104
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Adriana,
I have lung mets - several nodules in both lungs. I've been on Herceptin/Taxol/Carboplatin since July. Latest scan showed some improvement but also very slight progression in one nodule. I'm going to continue treatment with the Herceptin/Taxol and drop the Carboplatin.
__________________
Kate
Stage IIIC Diagnosed Oct 25, 2005 (age 58)
ER/PR-, HER2+++, grade 3, Ploidy/DNA index: Aneuploid/1.61, S-phase: 24.2%
Neoadjunct chemo: 4 A/C; 4 Taxatore
Bilateral mastectomy June 8, 2006
14 of 26 nodes positive
Herceptin June 22, 2006 - April 20, 2007
Radiation (X35) July 24-September 11, 2006
BRCA1/BRCA2 negative
Stage IV lung mets July 13, 2007 - TCH
Single brain met - August 6, 2007 -CyberKnife
Oct 2007 - clear brain MRI and lung mets shrinking.
March 2008 lung met progression, brain still clear - begin Tykerb/Xeloda/Ixempra
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01-25-2008, 10:25 AM
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#10
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Senior Member
Join Date: Mar 2006
Posts: 4,778
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As Jean alluded to, herceptin is felt to radiosensitize ie,
make whatever amount of radiation is given work more efficiently ie," more kill for your buck"
In addition, there is a combination treatment which also seems to make radiation work more efficiently AND protects the lung from post-radiation scarring
You might want to print out the abstracts from some of these:
1:
Related Articles, LinksJellett L, Harrison C, McAleese J.
Letter to editor. Re: "Effect of concomitant use of pentoxifylline (PTX) and alpha-tocopherol with radiotherapy on the clinical outcome of patients with stage IIIB non-small cell lung cancer".
Med Oncol. 2007;24(3):360. No abstract available.
PMID: 17873316 [PubMed - indexed for MEDLINE]
2:
Related Articles, LinksMisirlioglu CH, Demirkasimoglu T, Kucukplakci B, Sanri E, Altundag K.
Pentoxifylline and alpha-tocopherol in prevention of radiation-induced lung toxicity in patients with lung cancer.
Med Oncol. 2007;24(3):308-11.
PMID: 17873306 [PubMed - indexed for MEDLINE]
3:
Related Articles, LinksBese NS, Munzuroglu F, Uslu B, Arbak S, Yesiladali G, Sut N, Altug T, Ober A.
Vitamin E protects against the development of radiation-induced pulmonary fibrosis in rats.
Clin Oncol (R Coll Radiol). 2007 May;19(4):260-4. Epub 2007 Jan 12.
PMID: 17433970 [PubMed - indexed for MEDLINE]
4:
Related Articles, LinksMisirlioglu CH, Erkal H, Elgin Y, Ugur I, Altundag K.
Effect of concomitant use of pentoxifylline and alpha-tocopherol with radiotherapy on the clinical outcome of patients with stage IIIB non-small cell lung cancer: a randomized prospective clinical trial.
Med Oncol. 2006;23(2):185-9.
PMID: 16720918 [PubMed - indexed for MEDLINE]
5:
Related Articles, LinksNieder C, Zimmermann FB, Adam M, Molls M.
The role of pentoxifylline as a modifier of radiation therapy.
Cancer Treat Rev. 2005 Oct;31(6):448-55. Epub 2005 Oct 12. Review.
PMID: 16225996 [PubMed - indexed for MEDLINE]
6:
Related Articles, LinksOsterreicher J, Pejchal J, Skopek J, Mokrỳ J, Vilasová Z, Psutka J, Vávrová J, Mazurová Y.
Role of type II pneumocytes in pathogenesis of radiation pneumonitis: dose response of radiation-induced lung changes in the transient high vascular permeability period.
Exp Toxicol Pathol. 2004 Dec;56(3):181-7.
PMID: 15625787 [PubMed - indexed for MEDLINE]
7:
Related Articles, LinksOzturk B, Egehan I, Atavci S, Kitapci M.
Pentoxifylline in prevention of radiation-induced lung toxicity in patients with breast and lung cancer: a double-blind randomized trial.
Int J Radiat Oncol Biol Phys. 2004 Jan 1;58(1):213-9.
PMID: 14697441 [PubMed - indexed for MEDLINE]
8:
Related Articles, LinksRübe CE, Wilfert F, Uthe D, Schmid KW, Knoop R, Willich N, Schuck A, Rübe C.
Modulation of radiation-induced tumour necrosis factor alpha (TNF-alpha) expression in the lung tissue by pentoxifylline.
Radiother Oncol. 2002 Aug;64(2):177-87.
PMID: 12242128 [PubMed - indexed for MEDLINE]
9:
Related Articles, LinksOsterreicher J, Králik M, Navrátil L, Vávrová J, Skopek J, KnÃ*zek J, Macela A.
Apoptosis and bcl-2 expression in irradiated lungs and the effect of pentoxifylline.
Acta Medica (Hradec Kralove). 2001;44(4):125-30.
PMID: 11836847 [PubMed - indexed for MEDLINE]
10:
Related Articles, LinksOsterreicher J, Mokry J, Navrátil L, KnÃ*zek J, Vávrová J, Skopek J, Macela A.
The alveolar septal thickness and type II pneumocytes number in irradiated lungs, time expression and the effect of pentoxifylline.
Acta Medica (Hradec Kralove). 2001;44(1):15-9.
PMID: 11367886 [PubMed - indexed for MEDLINE]
11:
Related Articles, LinksKwon HC, Kim SK, Chung WK, Cho MJ, Kim JS, Kim JS, Moon SR, Park WY, Ahn SJ, Oh YK, Yun HG, Na BS.
Effect of pentoxifylline on radiation response of non-small cell lung cancer: a phase III randomized multicenter trial.
Radiother Oncol. 2000 Aug;56(2):175-9.
PMID: 10927136 [PubMed - indexed for MEDLINE]
12:
Related Articles, LinksJohnson FE, Harrison BR, McKirgan LW, Raju PI, Roy TK, Virgo KS.
A phase II evaluation of pentoxifylline combined with radiation in the treatment of brain metastases.
Int J Oncol. 1998 Oct;13(4):801-5.
PMID: 9735411 [PubMed - indexed for MEDLINE]
13:
Related Articles, LinksRussell KJ, Wiens LW, Demers GW, Galloway DA, Le T, Rice GC, Bianco JA, Singer JW, Groudine M.
Preferential radiosensitization of G1 checkpoint-deficient cells by methylxanthines.
Int J Radiat Oncol Biol Phys. 1996 Dec 1;36(5):1099-106.
PMID: 8985032 [PubMed - indexed for MEDLINE]
14:
Related Articles, LinksStelzer KJ, Koh WJ, Peterson LM, Griffin TW.
Effect of high-dose pentoxifylline on acute radiation-induced lung toxicity in a rat lung perfusion model.
Int J Radiat Oncol Biol Phys. 1996 Jan 1;34(1):111-5.
PMID: 12118538 [PubMed - indexed for MEDLINE]
15:
Related Articles, LinksKoh WJ, Stelzer KJ, Peterson LM, Staker BL, Ward WF, Russell KJ, Griffin TW.
Effect of pentoxifylline on radiation-induced lung and skin toxicity in rats.
Int J Radiat Oncol Biol Phys. 1995 Jan 1;31(1):71-7.
PMID: 7995770 [PubMed - indexed for MEDLINE]
16:
Related Articles, LinksRemiszewski P, Roszkowski K.
[Mechanisms of radiation to the lung. Pentoxifylline--a new radioprotective drug?]
Pneumonol Alergol Pol. 1995;63(5-6):349-54. Review. Polish. No abstract available.
PMID: 7581073 [PubMed - indexed for MEDLINE]
17:
Related Articles, LinksVernimmen F, Verheye-Dua F, du Toit H, Böhm L.
Effect of pentoxifylline on radiation damage and tumor growth.
Strahlenther Onkol. 1994 Oct;170(10):595-601.
PMID: 7974171 [PubMed - indexed for MEDLINE]
18:
Related Articles, LinksHoness DJ, Dennis IF, Bleehen NM.
Pentoxifylline: its pharmacokinetics and ability to improve tumour perfusion and radiosensitivity in mice.
Radiother Oncol. 1993 Sep;28(3):208-18.
PMID: 8255998 [PubMed - indexed for MEDLINE]
Hope this helps--the combo is Pentoxifylline (also known as trental) and vitamin E
What has confused me is the ?radioprotective drug, as one might postulate that either it makes radiation work better or protects the lung from radiation damage. But maybe it does one via one pathway and the other via another and the net effect is to both increase effectiveness and protect the "innocent tissue"
None of this has been tested in tens of thousands over many years, so you may get the ...there is not sufficient clinical evidence...answer.
But I remember you have an inquiring mind, so information may either ease or disturb it.
Hope this info does the former
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01-25-2008, 11:51 AM
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#11
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Senior Member
Join Date: Sep 2005
Posts: 556
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Adriana,
One of our members did cyberknife for her mediastinal met and it was successful, may be you can explore about this option since it is localized to one point in lung.
Julie
__________________
Diagnosed in Sept 2004 while pregnant with the second child. Stage 3b, tumor 4.5cm, 4 auxillary and supraclav node positive. Her2+++ FISH 9.4 and er-,pr-.
Had dose dense neoadjuvant AC,Taxol then mastectomy,radiation+xeloda+Herceptin.
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01-27-2008, 09:40 AM
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#12
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Senior Member
Join Date: Oct 2007
Posts: 1,851
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Adriana,
I had Herceptin and radiation to my breast concurrently without a problem.
Since your lung mets have been very stable for quite some time, you may want to consider finding out whether ablation is an option, as was suggested.
Would surgery be out of the question? How big are the mets, and how many are there?
I had surgery to remove a single met in the apex of my left lung, but I'm not sure that if I had had more than one met, surgery would have been an option. My nodule was 9mm.
It's really good that you're taking the time to find out your options and getting information.
Joan
__________________
Diagnosed stage 2b in July 2003 (2.3 cm, HER2+, ER-/PR-, 7+ nodes). Treated with mastectomy (with immediate DIEP flap reconstruction), AC + T/Herceptin (off label). Cancer advanced to lung in Jan. 2007 (1 cm nodule). Started Herceptin every 3 weeks. Lung wedge resection April 2007. Cancer recurred in lung April 2008. RFA of lung in August 2008. 2nd annual brain MRI in Oct. 2008 discovered 2.6 cm cystic tumor in left frontal lobe. Craniotomy Oct. 2008 (ER-/PR-/HER2-) followed by targeted radiation (IMRT). Coughing up blood Feb. 2009. Thoractomy July 2009 to cut out fungal ball of common soil fungus (aspergillus) that grew in the RFA cavity (most likely inhaled while gardening). No cancer, only fungus. Removal of tiny melanoma from upper left arm, plus sentinel lymph node biopsy in Feb. 2016. Guardant Health liquid biopsy in Feb. 2016 showed mutations in 4 subtypes of TP53. Repeat of Guardant Health biopsy in Jana. 2021 showed 3 TP53 mutations, BRCA1 mutation and CHEK2 mutation. Invitae genetic testing showed negative for all of these. Living with MBC since 2007. Stopped Herceptin Hylecta (injection) treatment in March 2020. Recent 2021 annual CT of chest, abdomen and pelvis and annual brain MRI showed NED. Praying for NED forever!!
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01-28-2008, 08:51 PM
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#13
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Senior Member
Join Date: Sep 2005
Location: St. George, UT
Posts: 582
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You've gotten some informative answers, Adriana. I don't have anything to add, as my lung mets did respond to navelbine and herceptin. I will be watching for your decision and treatments and success, and sending positive thoughts and prayers your way. Hugs, Tricia
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01-30-2008, 04:47 PM
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#14
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Senior Member
Join Date: May 2006
Location: California
Posts: 668
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No surgery for me
Dear Joan,
Onc said that surgery it's not a good choice for me. I guess the ca is in more than one place in the lung, but it's been stable since the recurrence in 2003. In short there is no indication that the ca has spread to other organs
It's really a hard decision for me to make alone, but one I must take no matter what...
Thanks so much for your response. I will keep you and everyone else posted.
__________________
1994 - rt brst, .lump, underarm node dissection,chemo+rad 1.2 cms, Grade 3.
28 nodes neg
Er,Pr, Positive HER2 status unknown
2003- Recur to rt lung.July 16 ( B-Day!)
Her2+++ Er,Pr, Negative
2003 - Aug04--Navelbine + Herceptin
2004- 2007--NED - Herceptin, only
2007 Feb-April Xeloda added to hereceptin
2007-May Back on Navelbine+Herceptin
2008-Feb-Mar 15 Ses Rad to Rt. Lung
2008- Oc 17 Add Tykerb to Herceptin
2009- June-- Discont Tykerb
2009 July 7--Current Taxol + Herceptin
2009 Dec--Discontinued treatment due to progression. Looking into cyberknife.
2010-Aug Accepted to TDM1, no SE, except liver count went up.
2010-2011 September got kicked out of the trial, due to a small spot found on lung.
2011- 2012 September thru early 2013 on Herceptin
2013- March Bone density shows small spot on 5th rib.
2013 - April 4th appt with onc. will post after discussing course of treatment.
2013-March-April Cyber knife to brain and radiation to rib. Chest --base line before chemo-CT-Scan stable for lung issue. CA2729 Normal.
2013 April Herceptin- TDMI
2013 Sept Herceptin + Perjeta . CA2729 within normal range. Brain and Pet scans October 31st. will post results.
2013 October Brain MRI- mixed response. Will see Onc/rad on Halloween.
2013 October/November Brain-MRI nothing new. Repeat MRI next year in May.
2013 December Continue Herceptin and Perjeta. Stable at the moment.
2014 February Brain MRI -clear!
2014 January Added Taxotere to Perjeta+Herceptin.
2014 March Stopped chemo-chest ct-scan next.
2014- March Scans shows tumor's larger, CA2729 higher. Discontinue Herceptin.
2014 April Perjeta+ Halaven
2014 April CA2729 went down 60 points after one cycle. Cough does not want to go away.
2014 June Continue on Perjeta + Halaven-- no more cough. Stable
2014 June Back on Herceptin + abraxane
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