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Old 05-19-2006, 12:28 AM   #1
DeborahNC
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Can I tell you my good news & ask a ?

My brain MRI was normal. I have been plagued with vision disturbances, balance problems and dizziness for weeks and was terrified of brain mets.

I asked my doctor if he thought Herceptin could be the culprit and he said he really didn't know. He suggested a Herceptin holiday to see if the symptom resolved after a time. Even the neuropathy from my Taxol treatment that I thought was gone has come back in my toes and fingers.

Has anyone else done Herceptin holiday? I've heard of the chemo holidays.

I really don't know what to do. My QOL is suffering, but I'm not sure Herceptin is to blame.

Any input is appreciated.
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Old 05-19-2006, 04:22 AM   #2
Sheila
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Deborah
I have not but many on this site have taken a break for various reasons. Just remember, I believe you must take the reloading dose when you go back on it!

Hope this break gets you feeling better....everyone seems to react differently to it. This should give you the answer.
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is fighting some kind of battle."



Hugs & Blessings
Sheila
Diagnosed at age 49.99999 2/21/2002 via Mammography (Calcifications)
Core Biopsy 2/22/02
L. Mastectomy 2/25/2002
Stage 1, 0.7cm IDC, Node Neg from 19 nodes Her2+++ ER PR Neg
6/2003 Reconstruction W/ Tissue Expander, Silicone Implant
9/2003 Stage IV with Mets to Supraclavicular nodes
9/2003 Began Herceptin every 3 weeks
3/2006 Xeloda 2500mg/Herceptin for recurrence to neck nodes
3/2007 Added back the Xeloda with Herceptin for continued mets to nodes
5/2007 Taken Off Xeloda, no longer working
6/14/07 Taxol/Herceptin/Avastin
3/26 - 5/28/08 Taxol Holiday Whopeeeeeeeee
5/29 2008 Back on Taxol w Herceptin q 2 weeks
4/2009 Progression on Taxol & Paralyzed L Vocal Cord from Nodes Pressing on Nerve
5/2009 Begin Rx with Navelbine/Herceptin
11/09 Progression on Navelbine
Fought for and started Tykerb/Herceptin...nodes are melting!!!!!
2/2010 Back to Avastin/Herceptin
5/2010 Switched to Metronomic Chemo with Herceptin...Cytoxan and Methotrexate
Pericardial Window Surgery to Drain Pericardial Effusion
7/2010 Back to walking a mile a day...YEAH!!!!
9/2010 Nodes are back with a vengence in neck
Qualified for TDM-1 EAP
10/6/10 Begin my miracle drug, TDM-1
Mixed response, shrinking internal nodes, progression skin mets after 3 treatments
12/6/10 Started Halaven (Eribulen) /Herceptin excellent results in 2 treatments
2/2011 I CELEBRATE my 9 YEAR MARK!!!!!!!!!!!!!
7/5/11 begin Gemzar /Herceptin for node progression
2/8/2012 Gemzar stopped, Continue Herceptin
2/20/2012 Begin Tomo Radiation to Neck Nodes
2/21/2012 I CELEBRATE 10 YEARS
5/12/2012 BeganTaxotere/ Herceptin is my next miracle for new node progression
6/28/12 Stopped Taxotere due to pregression, Started Perjeta/Herceptin
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Old 05-19-2006, 08:43 AM   #3
tousled1
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Deboarh,

Glad to hear your brain MRI results were good. I always like to hear good news. Good luck to you.
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Stage IIIC Diagnosed Oct 25, 2005 (age 58)
ER/PR-, HER2+++, grade 3, Ploidy/DNA index: Aneuploid/1.61, S-phase: 24.2%
Neoadjunct chemo: 4 A/C; 4 Taxatore
Bilateral mastectomy June 8, 2006
14 of 26 nodes positive
Herceptin June 22, 2006 - April 20, 2007
Radiation (X35) July 24-September 11, 2006
BRCA1/BRCA2 negative
Stage IV lung mets July 13, 2007 - TCH
Single brain met - August 6, 2007 -CyberKnife
Oct 2007 - clear brain MRI and lung mets shrinking.
March 2008 lung met progression, brain still clear - begin Tykerb/Xeloda/Ixempra
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Old 05-19-2006, 09:57 AM   #4
R.B.
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Please look at the posts on omega three and six, fats, brain health etc.

Use the search on the purple bar above right.

You might like to print bits out and take them with you to your advisor if that would help.

Murine trials have shown that DHA is taken quite quickly into the brain if it is deficient.

It might help - I would be interested to know as well.

If you have already got this covered I would be interested too.

Please do talk to your advisors about any dietary changes.

RB
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Old 05-19-2006, 04:20 PM   #5
lexigirl
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Smile

I don't know about the herceptin holiday, but wanted to say that I am so very happy that your brain scan is clear!! That's great!!

Lexi
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Old 05-19-2006, 04:51 PM   #6
Lisa
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Glad to hear your brain MRI was clear! Considering the symptoms you've had, have you had a PET scan or a CT of your spine lately?


Love and light,

Lisa
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