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07-07-2010, 03:09 PM
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#1
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Senior Member
Join Date: Mar 2006
Posts: 4,778
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Believe 51--are you out there? BRCA2 related male breast cancer
Men With Faulty Gene Have 1 In 15 Chance Of Breast Cancer By Age 70
Article Date: 06 Jul 2010 - 3:00 PDT
Men who carry a faulty BRCA2 gene have a 1 in 15 chance of developing breast cancer by the time they reach 70, suggests the largest study of its kind, published online in the Journal of Medical Genetics.
Carriage of a faulty BRCA2 gene in women significantly increases their chances of developing breast cancer, and often at a young age. But it has not been clear whether men are susceptible, largely because few studies have been carried out, and published research has been based on retrospective data.
In the current study the research team used both retrospective and prospective data from 321 families with a faulty BRCA2 gene.
The families were identified at two genetic centres, serving a population of around 10 million people, in Manchester and Birmingham in Central North West England.
Twenty men among the 321 families had developed breast cancer between the ages of 29 and 79, and there were a total of 905 first degree male relatives (parent or sibling) of known BRCA2 carriers.
Among these first degree relatives, 16 men (2%) had developed the disease. Eight further cases of breast cancer occurred in second degree relatives, two of whom were also BRCA2 carriers.
On the basis of these figures, the lifetime risk of developing breast cancer in men by the age of 70 is one in 15 (7.1%), and one in 12 (8.4%) by the age of 80.
And on the basis of all the research published on the risks of breast cancer in men with a faulty BRCA2 gene, the authors suggest that men in the West have a lifetime risk of between 6% and 9%.
"These risks are sufficient to increase awareness of breast cancer among men in BRCA2 families and to stress the importance of early presentation with breast symptoms," conclude the authors.
Risk of breast cancer in male BRCA2 carriers J Med Genet Online First 2010; doi 10.1136/jmg.2009.075176
Source:
British Medical
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07-07-2010, 03:12 PM
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#2
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Senior Member
Join Date: Apr 2009
Location: La Quinta, Ca
Posts: 253
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Re: Believe 51--are you out there? BRCA2 related male breast cancer
Don't men with a faulty BRCA2 gene also have a higher risk of prostate cancer?
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08-14-2010, 08:13 PM
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#3
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Senior Member
Join Date: Jun 2007
Location: RHODE ISLAND
(Ed getting me a latte on 2nd Cancerversary Cruise 2008)
'BELIEVE': To accept as true or real, To have faith in, To presume
ALWAYS BELIEVE
Posts: 2,999
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Re: Believe 51--are you out there? BRCA2 related male breast cancer
I am here Santa...lol. I have been doing continued research on male breast cancer, IBC and bone and brain mets...It has been 10 of the longest months without him. Please keep this coming. I send love and prayers to you today and always!>>Believe51
__________________
9/7/06Husband 50yrs=StageIV IBC/HER2+,BoneMets10/06TaxotereX10,'H'1X wk,Zometa,Tamoxifen4/12/07Last Tax5/18/07Pet=Rapid Cell Activity,No Organ Mets,Lytic Lesions,Degeneration,Some Bone Repair5/07ChemoFail6/01/07Pleural Thoracentisis=Effusions,NoMalignantCells6/19/07+7/2/07DFCI
6/25/07BrainMRI=BrainMets,Many<9mm7/10/07WBR/PelvisRad37.5Gx15&Nutritionist8/19/07T/X9/20/07BrainMRI=2<2mm10/6/07Pet=BoneProgression
10/24/07ChemoFail11/9/07A/Cx10,EndTam12/7/07Faslodex12/10/07Muga7512/13/07BlasticLesions1/7/08BrainMRI=Clear4/1/08Pet=BoneImprovement,
NoProgression,Stable4/7/08BrainPerfect5/16/08Last A/C8/26/08BrainMets=10(<9mm)9/10/08Gamma10/30/08Met=5mm12/19/08Gamma5mets5
12/22/08SpinalMets1/14/09SpinalRads2/17/09BrainMRI=NoNewMets4/20/09BoneScan5/14/09Ixempra6/1/09BrainMRI=NumerousMets6/24/09DFCIw/DrBurstein6/26/09Continue
Ixempra/Faslodex/Zometa~TM now lower7/17/09Stop Ixempra By Choice9/21/09HOSPICE10/16/09Earned His Deserved Wings And Halo=37 Month Fight w/Stage 4 IBC, Her2+++,My Hero!!
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08-17-2010, 01:34 PM
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#4
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Senior Member
Join Date: Jan 2008
Posts: 154
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Re: Believe 51--are you out there? BRCA2 related male breast cancer
I can certainly say that this is most likely correct. When they tested my genes they found a mutation that had only been seen 14 other times. The company offered to test my whole immediate family for free so that they could study it further
__________________
Diagnosis and Treatment: DX 12/07/07
Male Diagnosed with DCIS at age 39
Mastectomy on right breast
Tumor Stage pt1b NO MO
DCIS Tumor size 1.5 x 1.x .6cm
Infiltration tumor size .25X.17 cm
Bloom-Richardson Grade 3(score 8)
Nuclear Grade 3 with comedo necrosis
Estrogen+/Progestrone+/HER-2/Neu +++
FISH ratio 4.31
Lymph node removal scheduled 1/07/08
17 nodes tested and all negative 1/08/08
Started Tamoxifin 1/29/08
Oncotype DX score 52 (off the charts, according to my onc!!!)
Starting TCH 3/14/08
BRCA I Positive BRCA II Negative
Finished TC 6/27/08 continue Herceptin
8/1/08 Herceptin stopped due to low Muga score
Mastectomy on left breast 11/10/08
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08-21-2010, 08:44 PM
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#5
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Senior Member
Join Date: Sep 2005
Location: Naples FL
Posts: 1,744
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Re: Believe 51--are you out there? BRCA2 related male breast cancer
How worried should I be about my sons...as a BRCA2+ mom???
__________________
Suzan W.
age 54 at diagnosis
5/05 suspicious mammogram-left breast
5/05 biopsy-invasive lobular carcinoma with LCIS,8mm tumor,stage 1 grade 2, ER+ PR+ Her2+++
6/14/05 bilateral mastectomy, node neg. all scans neg.
Oncotype DX-high risk
8/05-10/05 4 rounds A/C
10/05 -10/06 1 yr. herceptin
arimidex-5 years
2/14/08 started daily self administered injections..FORTEO for severe osteoporosis
7/28/09 BRCA 1 negative BRCA2 POSITIVE
8/17/09 prophylactic salpingo-oophorectomy
10/15/10 last FORTEOinjection
RECLAST infusion(ostoeporosis)
6/14/10 5 year cancerversary!
8/2010-18%increase in bone density!
no further treatments
Oncologist says, "Go do the Happy Dance"
I say,"What a long strange trip its been"
'One day at a time'
6-14-2015. 10 YEAR CANCERVERSARY!
7-16 to 9-16. Extensive (and expensive) dental work done to save teeth. Damage from osteoporosis and chemo and long term bisphosphonate use
6-14-16. 11 YEAR CANCERVERSARY!!
7-20-16 Prolia injection for severe osteoporosis
2 days later, massive hive outbreak. This led to an eventual dx of Chronic Ideopathic Urticaria, an auto-immune disease from HELL.
6-14-17 12 YEAR CANCERVERSARY!!
still suffering from CIU. 4 hospitilizations in the past year
as of today, 10-31-17 in remission from CIU and still, CANCER FREE!!!
6-14-18 13 YEAR CANCERVERSARY!! NED!!
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08-29-2010, 12:32 AM
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#6
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Senior Member
Join Date: Mar 2007
Location: Hilo, Hawaii
Posts: 1,867
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Re: Believe 51--are you out there? BRCA2 related male breast cancer
Yes, BRCA2 gene in males also has an increased risk of prostate cancer.
Suzan, I think it would be wise to have your sons tested. At what age, I am not sure.
__________________
*** MARYANNE *** aka HARRIECANARIE
1993: right side DCIS, lumpectomy, rads
1999: left side DCIS, lumpectomy, rads, tamoxifen
2006:
BRCA 2 positive
Stage I, invasive DCIS (6mm x 5mm)
Grade: intermediate
sentinal node biopsy: neg
HER2/neu amplified 4.7
ER+/PR+
TOPO II neg
Oncotype dx 20
Bilat mastectomy with DIEP flap reconstruction
oophorectomy
2007:
6 cycles TCH (taxotere, carboplatin, herceptin)
finished 1 yr herceptin 05/07
Arimidex, stopped after almost 1 yr
Femara
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