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Old 12-12-2012, 11:08 AM   #1
Nguyen
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looking for data on Pertuzumab + Vinorelbine + Trastuzumab

Hello,

Does anyone happen to have efficacy data on the combination Pertuzumab + Trastuzumab + Vinorelbine?

Alternatively, there is a phase 2 trial (Velvet) by Dr. Edith Perez for this combination. I believe the result was presented at ASCO 2012, but I couldn't access the podcast without ASCO full membership. Does anyone have ASCO full membership?

Many thanks,

Nguyen
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Old 12-12-2012, 01:22 PM   #2
chrisy
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Re: looking for data on Pertuzumab + Vinorelbine + Trastuzumab

I don't have data but this is the trial I think
http://clinicaltrials.gov/ct2/show/s...ow_locs=Y#locn
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June 2002 extensive hi grade DCIS (pre-cancer-stage 0, clean sentinal node) Mastectomy/implant - no chemo, rads. "cured?"
9/2004 Diag: Stage IV extensive liver mets (!) ER/PR- Her2+++
10/04-3/05 Weekly Taxol/Carboplatin/Herceptin , complete response!
04/05 - 4/07 Herception every 3 wks, Continue NED
04/07 - recurrence to liver - 2 spots, starting tykerb/avastin trial
06/07 8/07 10/07 Scans show stable, continue on Tykerb/Avastin
01/08 Progression in liver
02/08 Begin (TDM1) trial
08/08 NED! It's Working! Continue on TDM1
02/09 Continue NED
02/10 Continue NED. 5/10 9/10 Scans NED 10/10 Scans NED
12/10 Scans not clear....4/11 Scans suggest progression 6/11 progression confirmed in liver
07/11 - 11/11 Herceptin/Xeloda -not working:(
12/11 Begin MM302 Phase I trial - bust:(
03/12 3rd times the charm? AKT trial

5/12 Scan shows reduction! 7/12 More reduction!!!!
8/12 Whoops...progression...trying for Perjeta/Herceptin (plus some more nasty chemo!)
9/12 Start Perjeta/Herceptin, chemo on hold due to infection/wound in leg, added on cycle 2 &3
11/12 Poops! progression in liver, Stop Perjeta/Taxo/Herc
11/12 Navelbine/Herce[ptin - try for a 3 cycles, no go.
2/13 Gemzar/Carbo/Herceptin - no go.
3/13 TACE procedure
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Old 12-12-2012, 04:19 PM   #3
Rolepaul
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Re: looking for data on Pertuzumab + Vinorelbine + Trastuzumab

This is a multicenter trial that is recruiting patients.
http://www.clinicaltrials.gov/ct2/sh...uzumab&rank=15
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Old 12-12-2012, 06:47 PM   #4
StephN
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Re: looking for data on Pertuzumab + Vinorelbine + Trastuzumab

I would be inclined to think that any trial run by Dr. Edith Perez would be a good one.

She did a lot of work on the early Herceptin trials, and continues to take a deep interest in HER2 positive BC.
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MY STORY SO FAR ~~~~
Found suspicious lump 9/2000
Lumpectomy, then node dissection and port placement
Stage IIB, 8 pos nodes of 18, Grade 3, ER & PR -
Adriamycin 12 weekly, taxotere 4 rounds
36 rads - very little burning
3 mos after rads liver full of tumors, Stage IV Jan 2002, one spot on sternum
Weekly Taxol, Navelbine, Herceptin for 27 rounds to NED!
2003 & 2004 no active disease - 3 weekly Herceptin + Zometa
Jan 2005 two mets to brain - Gamma Knife on Jan 18
All clear until treated cerebellum spot showing activity on Jan 2006 brain MRI & brain PET
Brain surgery on Feb 9, 2006 - no cancer, 100% radiation necrosis - tumor was still dying
Continue as NED while on Herceptin & quarterly Zometa
Fall-2006 - off Zometa - watching one small brain spot (scar?)
2007 - spot/scar in brain stable - finished anticoagulation therapy for clot along my port-a-catheter - 3 angioplasties to unblock vena cava
2008 - Brain and body still NED! Port removed and scans in Dec.
Dec 2008 - stop Herceptin - Vaccine Trial at U of W begun in Oct. of 2011
STILL NED everywhere in Feb 2014 - on wing & prayer
7/14 - Started twice yearly Zometa for my bones
Jan. 2015 checkup still shows NED
2015 Neuropathy in feet - otherwise all OK - still NED.
Same news for 2016 and all of 2017.
Nov of 2017 - had small skin cancer removed from my face. Will have Zometa end of Jan. 2018.
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