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Old 12-06-2007, 11:49 AM   #1
murph
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Join Date: Nov 2007
Location: New Jersey
Posts: 25
Oncotype Dx test????

Hello everyone,

Could someone explain to me what exactly the Oncotype Dx test is? And, also is it something all Dr.s do? I have my pathology report and do not see anything in regards to that on it. Thanks,

Pam
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Pam (age 40)
bi-lat mastectomy no recons.
4 IDC along with 4 DCIS
no node involvement SNB (8 nodes removed)
Her2+++ FISH (all 4 primaries)
3 ER pos & 1 primary ER/PR pos
2 primaries Grade II other 2 Grade III
sizes of tumors 1st .8cm 2nd .7cm 3rd 1.2cm 4th .7cm
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Old 12-06-2007, 12:47 PM   #2
suzan w
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Hi Pam, The oncotype dx is used to determine one's chances of "distant recurrence". It is not done unless you or your doctor ask for it. It is done by only one independent lab. Many times insurance does not cover it. The lab will fight your insurance company for payment (they did it successfully for me...the test is VERY pricey). I have since learned that most Her2+ cancers score at moderate to high risk for recurrence on this test. When I had the test done, folks were just starting to see the correlation between Her2+ and high oncotype results. I am glad that I had the test done as it was one more piece of information for me to use when determining what my treatment would be!
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Suzan W.
age 54 at diagnosis
5/05 suspicious mammogram-left breast
5/05 biopsy-invasive lobular carcinoma with LCIS,8mm tumor,stage 1 grade 2, ER+ PR+ Her2+++
6/14/05 bilateral mastectomy, node neg. all scans neg.
Oncotype DX-high risk
8/05-10/05 4 rounds A/C
10/05 -10/06 1 yr. herceptin
arimidex-5 years
2/14/08 started daily self administered injections..FORTEO for severe osteoporosis
7/28/09 BRCA 1 negative BRCA2 POSITIVE
8/17/09 prophylactic salpingo-oophorectomy
10/15/10 last FORTEOinjection
RECLAST infusion(ostoeporosis)
6/14/10 5 year cancerversary!
8/2010-18%increase in bone density!
no further treatments
Oncologist says, "Go do the Happy Dance"
I say,"What a long strange trip its been"
'One day at a time'
6-14-2015. 10 YEAR CANCERVERSARY!
7-16 to 9-16. Extensive (and expensive) dental work done to save teeth. Damage from osteoporosis and chemo and long term bisphosphonate use
6-14-16. 11 YEAR CANCERVERSARY!!
7-20-16 Prolia injection for severe osteoporosis
2 days later, massive hive outbreak. This led to an eventual dx of Chronic Ideopathic Urticaria, an auto-immune disease from HELL.
6-14-17 12 YEAR CANCERVERSARY!!
still suffering from CIU. 4 hospitilizations in the past year

as of today, 10-31-17 in remission from CIU and still, CANCER FREE!!!
6-14-18 13 YEAR CANCERVERSARY!! NED!!
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Old 12-06-2007, 01:00 PM   #3
Jean
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Pam,
The oncotype DX test is a gene analysis of your tumor. A speciaman of your tumor tissue (parafin) slide.

This test will advise the likelihood that invasive breast cancer will return, or recur, the test uses gene expression profile of your tumor. It is also
useful for those who are on the fence about chemo treatment. The information can assist a patient in making a treatment decision.

The test will return a recurrence score which is a number between 0 and 100 that corresponds to the likelihood of breast cancer recurence within a 10 yr. period.

I had the test done. My insurance did cover it. It is now used by many onc. I will share with you that you should check your KI-67 level from your pathology report (mine was 40%) if yours is high - that is a strong indication. When I saw Dr. Slamon he said I didn't even need to do the test since KI -67 was so high. Most her2 - er postive will read high
(I do not know why)...but at the time my onc. were saying I did not require chemo/herceptin due to small tumor. I do not know your circumstances, if you are on the fence with having chemo etc.
But to the point - the Oncotype DX test is for women who are unsure if they should have chemo.

Hope this helps.
Kind Regards,
Jean
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Stage 1, Grade 1, 3/30/05
Lumpectomy 4/15/05 - 6MM IDC
Node Neg. (Sentinel node)
ER+ 90% / PR-, Her2+++ by FISH
Ki-67 40%
Arimidex 5/05
Radiation 32 trt, 5/30/05
Oncotype DX test 4/17/06, 31% high risk
TOPO 11 neg. 4/06
Stopped Arimidex 5/06
TCH 5/06, 6 treatments
Herceptin 5/06 - for 1 yr.
9/06 Completed chemo
Started Femara Sept. 2006
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Old 12-06-2007, 02:44 PM   #4
murph
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Jean & Suzan,

Thank you. I do not see Ki-67 on my path either. I will have to ask doc about that one. I had 4 cycles of AC followed by 12 straight wks of Taxol, radiation was in question, but radiologist said not needed. Now on Herceptin til May. He is waiting for results of study, in regards to benefit of 2 yrs. of Herceptin.
Pam
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Pam (age 40)
bi-lat mastectomy no recons.
4 IDC along with 4 DCIS
no node involvement SNB (8 nodes removed)
Her2+++ FISH (all 4 primaries)
3 ER pos & 1 primary ER/PR pos
2 primaries Grade II other 2 Grade III
sizes of tumors 1st .8cm 2nd .7cm 3rd 1.2cm 4th .7cm
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Old 12-06-2007, 03:09 PM   #5
Alice
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From what little I recal the onco type test is only for ER+ and there is no test like it for ER-. I could be wrong.
Alice
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Old 12-06-2007, 03:16 PM   #6
Jean
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Join Date: Oct 2005
Location: New Jersey
Posts: 3,154
Alice,
Your correct - patient has to be er positive for the test.

Jean
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Stage 1, Grade 1, 3/30/05
Lumpectomy 4/15/05 - 6MM IDC
Node Neg. (Sentinel node)
ER+ 90% / PR-, Her2+++ by FISH
Ki-67 40%
Arimidex 5/05
Radiation 32 trt, 5/30/05
Oncotype DX test 4/17/06, 31% high risk
TOPO 11 neg. 4/06
Stopped Arimidex 5/06
TCH 5/06, 6 treatments
Herceptin 5/06 - for 1 yr.
9/06 Completed chemo
Started Femara Sept. 2006
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