|
(I feel it's better if text of articles posted when not too huge)
Proton pump inhibitor suppresses H. pylori-induced angiogenesis
Posted: January 05, 2006
NEW YORK (Reuters Health) - The proton pump inhibitor, pantoprazole, suppresses angiogenesis induced by Helicobacter pylori, according to a report in the January 2006 issue of Gut.
Previous investigators have suggested that angiogenic growth factors induced by H. pylori might be related to inflammation or carcinogenesis, the authors explain, and recent evidence indicates that H. pylori stimulates host expression of vascular endothelial growth factor (VEGF).
Dr. M. Yeo from Ajou University Medical Center, Suwon, Korea and colleagues investigated the effects of pantoprazole on angiogenesis in tissues infected with H. pylori.
Tissues from patients with H. pylori positive-gastritis showed significantly higher expression of CD34-positive blood vessels in the gastric mucosa layer than did tissues from patients with H. pylori-negative gastritis, the authors report. Blood vessels were also thicker and larger in patients with H. pylori positive gastritis.
H. pylori-infected gastric epithelium produce significantly higher levels of VEGF and IL-8 than did uninfected gastric epithelium, the results indicate.
In vitro treatment of H. pylori-infected cells with pantoprazole significantly suppressed IL-8 expression and VEGF synthesis and inhibited angiogenesis, the researchers note. Proton pump inhibitor treatment appeared to attenuate angiogenesis by inactivating the MAPK pathway, the investigators suggest, one of the principal signals for H. pylori-induced angiogenesis.
"The current data indicate that as H. pylori infection causally promoted host angiogenesis, which has been attributed to either augmented inflammation or enhanced carcinogenesis, proton pump inhibitors could be potentially used for inhibition of H. pylori-provoked angiogenesis," the authors conclude.
|
Linear Mode
