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Old 10-11-2013, 10:07 PM   #1
Lani
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Thumbs up how her2+breast cancer subtypes differ(and why some respond better2 targeted therapy

I have previously commended Maurizio Scaltriti, who did the original preclinical research showing the supersynergism of herceptin plus lapatinib --the basis for the neoadjuvant studies and for the combined treatment many of you have benefitted from


http://www.readcube.com/articles/10....4269?locale=en
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Old 10-12-2013, 04:14 PM   #2
tricia keegan
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Re: how her2+breast cancer subtypes differ(and why some respond better2 targeted ther

Lani I had trouble reading this, would you mind condensing it for me please??
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Tricia
Dx July '05 IDC 1.9cm Triple positive 3/9 nodes positive
A/C X 4 ..Taxol/Herceptin x 12 wks then herceptin 1 yr
Rads x 36 ..oophorectomy August '06
Currently taking Arimidex..
June 2011 osteopenia/ zometa x1 yearly- stopped Zometa 2015 as Dexa show normal bone density.
Stopped Arimidex July 2014- Restarted Arimidex 2015 for a further two years on the advice of my Onc.
2014 Normal Dexa scan
2018 Mammo all clear, still NED!
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Old 10-12-2013, 04:20 PM   #3
'lizbeth
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Re: how her2+breast cancer subtypes differ(and why some respond better2 targeted ther

I had a similar problem, after the abstract the pages were blurred. I'm sure the information is fascinating. I second Tricia's request.
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Old 10-14-2013, 08:12 AM   #4
linn65
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Re: how her2+breast cancer subtypes differ(and why some respond better2 targeted ther

My iPad wouldn't open this article, but I would like a analogy I am sure....I think Lani should just write a page and then list the article for super science genius people to read if they like!��
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myleftlump.wordpress.com - started blogging my
IDC breast cancer
7/2012 diagnosed with multiple solid lesions
7/20/12 biopsy done. ER+ 30 PR -, HER+++,k167 80% Grade 2
9/2012 biopsy on lymph node - showed malignant

9/2012 Pre-adjunctive TCH chemo.

12/6/12 MRI after Pre-adj.
Results: Modest Decrease in size of left breast malignancy As well as the associated satellite lesions and auxiliary Adenopathy compared to prior study. Doctors hoped for better but good response it didn't grow.

12/18/2012 left masectomy with axillary nodes
Size 3.2 CM, Nottingham score 9/9
Grade 3, no evidence of in situ carcinoma
Areas of angiolymphatic are identified
Carcinoma is 0.5 cm from inked deep
Margin of excision
Attached axillary lymph nodes: metastatic
Carcinoma in 6 of 8 nodes.
Size of largest node 1.5 cm
Extracapsular
ER + 73%, PR+2%, HER2+

2/27/13 6 weeks of IMRT radiation finished

2/2013 Started on Tamoxifan 5 years.

8/2013 will take last Herceptin, 17 treatments total every 3 weeks.

BRCA1 & BRAC2 - Negative

August 28, 2013 DIEP flap on the left breast.
February 2014 Nip & Tuck
March 14, 2014 nipple reconstruction and removed port.
August 14, 2014 lump in lymph nodes under arm and above clavicle. Stage IV
August 28, 2014 herceptin And projeta starting and port put back in.

3/18/15 stopped arimidex.
3/18/15 progression....Tdm1
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