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Old 04-21-2007, 07:27 PM   #1
eric
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Tykerb/Xeloda - help with side effects?

Hi all,

Caryn just finished her 2nd week and she's having trouble with mouth sores and fatigue. The sores aren't surprising but the fatigue is. Has any one else experienced this? Any recommendations would be appreciated.

Thank you,
Eric
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Old 04-22-2007, 05:19 AM   #2
Sheila
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Eric

Has she had her counts checked? Xeloda can cause a drop of red counts in many people. Usually you have to have them done the week after you take the xeloda for an accurate count.
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Diagnosed at age 49.99999 2/21/2002 via Mammography (Calcifications)
Core Biopsy 2/22/02
L. Mastectomy 2/25/2002
Stage 1, 0.7cm IDC, Node Neg from 19 nodes Her2+++ ER PR Neg
6/2003 Reconstruction W/ Tissue Expander, Silicone Implant
9/2003 Stage IV with Mets to Supraclavicular nodes
9/2003 Began Herceptin every 3 weeks
3/2006 Xeloda 2500mg/Herceptin for recurrence to neck nodes
3/2007 Added back the Xeloda with Herceptin for continued mets to nodes
5/2007 Taken Off Xeloda, no longer working
6/14/07 Taxol/Herceptin/Avastin
3/26 - 5/28/08 Taxol Holiday Whopeeeeeeeee
5/29 2008 Back on Taxol w Herceptin q 2 weeks
4/2009 Progression on Taxol & Paralyzed L Vocal Cord from Nodes Pressing on Nerve
5/2009 Begin Rx with Navelbine/Herceptin
11/09 Progression on Navelbine
Fought for and started Tykerb/Herceptin...nodes are melting!!!!!
2/2010 Back to Avastin/Herceptin
5/2010 Switched to Metronomic Chemo with Herceptin...Cytoxan and Methotrexate
Pericardial Window Surgery to Drain Pericardial Effusion
7/2010 Back to walking a mile a day...YEAH!!!!
9/2010 Nodes are back with a vengence in neck
Qualified for TDM-1 EAP
10/6/10 Begin my miracle drug, TDM-1
Mixed response, shrinking internal nodes, progression skin mets after 3 treatments
12/6/10 Started Halaven (Eribulen) /Herceptin excellent results in 2 treatments
2/2011 I CELEBRATE my 9 YEAR MARK!!!!!!!!!!!!!
7/5/11 begin Gemzar /Herceptin for node progression
2/8/2012 Gemzar stopped, Continue Herceptin
2/20/2012 Begin Tomo Radiation to Neck Nodes
2/21/2012 I CELEBRATE 10 YEARS
5/12/2012 BeganTaxotere/ Herceptin is my next miracle for new node progression
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Old 04-22-2007, 01:27 PM   #3
anne2
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Eric,

I would recommend Biotene products for mouth sores and dry mouth. You can also get a mouthwash with seaweed extract and dead sea minerals at WholeFoods which seemed to help my mom with the oral mucosa. If one is really bothering her, look for a laser dentist that can treat it to heal faster and eliminate some of the pain.
Hugs,
Anne
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Old 04-22-2007, 03:01 PM   #4
Lolly
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Eric, I was on Xeloda for about a year with Herceptin, and experienced moderate tiredness, but nothing too dramatic. Don't know about Tykerb yet, won't start until next week, with Taxol. Try posting your question on the new Herceptin/Tykerb Board...

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Old 04-23-2007, 06:55 AM   #5
Shell
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Eric-

I am always fatigued while on chemo, but didn't think xeloda was tougher than any of the other regimes. I remember when tykerb was first added, I had a few days of being VERY tired, but after that it moderated back to what was normal for me... Good luck w/ the mouthsores.

Regards,
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init diag 3/17/03-stage IIIC
ER-/PR-/HER2+++
CET x4 neo-adjuvant
lump & SNB 8/03
CET x2
radiation and herceptin/navelbine 11-03-1/04
1st reoccur to lymph nodes 8/04
complete axillary dissection 12/04
herceptin/taxotere til progression (lungs) 3/05
xeloda w/out lapatinib trial 6/05
lapatinib/tykerb added 4/06
ended trial 8/06 due to progression
doxil / avastin 11/06-12/06 - wasn't working
navelbine/herceptin/avastin 12/06/3/07 - progression
gemzar/carboplatin/tykerb 4/07
mri shows extensive mets to bone in pelvic area 6/07
switched to abraxane (3 on/1 off) + tykerb 6/07
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