Anyone Heard of this Drug

tracey2424 · 02-13-2008, 09:32 AM

I have found out the name of the frug ny onc wants me to start in a clinical trial its called (Eribulin Mesylate) any info on this would be greatly appreciated it has been ongoing in the US for sometime in phase 1+2 trials.
What i really want to know is will i loose my hair again i really am dreading this its only just coming back.
Not sure whether to just go back to Xelodia which was very tolerable.
This is such a hard decision it really is getting me down.

Advice needed.

Tracey.

Lani · 02-13-2008, 10:21 AM

http://meeting.ascopubs.org/cgi/cont.../18_suppl/7546

Lani · 02-13-2008, 10:23 AM

Novel Agents for Advanced Breast Cancer

Several abstracts described new agents in development for the treatment of refractory breast cancer. Eribulin mesylate is a synthetic analog of halichondrin B, a microtubule inhibitor. A phase 2 study[7] analyzed the effect of eribulin mesylate in chemotherapy-refractory metastatic breast cancer. In this trial of approximately 100 women, there was an average of 5 prior chemotherapy regimens (including adjuvant treatment). The overall response rate was 11%. A slightly higher response rate was seen in women treated on a 2-weeks-on, 1-week-off schedule, compared with the 3-weeks-on, 1-week-off schedule. Neutropenia was the major grade 3 or 4 toxicity, though 5% of patients also had grade 3 neuropathy.

Also--
http://pubs.acs.org/cen/business/85/8541bus1box.html

and
http://www.foxbusiness.com/markets/i...461024_10.html

BonnieR · 02-13-2008, 10:48 AM

Sounds like you have alot of questions for your oncologist so you can make an informed decision.

I remember when I was dreading hair loss, my oncologist simply said "it grows back". And as sad as it was to loose my hair, she was right of course. It is a reversible part of the process.

Let us know what you decide...