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10-09-2009, 11:41 PM
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#1
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Senior Member
Join Date: Mar 2006
Posts: 4,778
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herceptin benefit in those with small (,2cm) node negative her2+ tumors
Oops! I was trying to type <2cm
at ASCO breast meeting currently in SF
Abstract 228 Poster Discussion: Systemic Mgmt. Thursday, October 8, 2009 6:00-7:00 PM PST
Lead Author: Heather L. McArthur, MD, MPH Memorial Sloan-Kettering Cancer Center New York, NY
Women with small node-negative HER2+ breast tumors appear to benefit from adjuvant trastuzumab (Herceptin) treatment: Based on a review of approximately 500 records of patients treated between Jan. 2002 and Dec. 2008, researchers found that women with small (2 cm or less) HER2-positive breast cancers that had not spread to lymph nodes who received trastuzumab-based treatment after surgery had significantly better outcomes than a comparable population of women treated before trastuzumab was available (Jan. 2002 through May 15, 2004). In the trastuzumab-treated group, there was only one death and no recurrences. In the trastuzumab-naive group, there were ten locoregional recurrences, nine distant recurrences and six deaths. In the U.S., adjuvant trastuzumab is FDA-approved in combination with chemotherapy for the treatment of node-positive or high-risk, node-negative, HER2-positive breast cancer; however, whether women with lower risk, HER2-positive breast cancer derive benefit from trastuzumab has not been established.
“This is a provocative analysis suggesting a significant benefit in disease- free survival for patients with Stage I breast cancer who received trastuzumab,” said Lori Pierce, MD, Professor, Radiation Oncology, University of Michigan School of Medicine.“It will be important to test this hypothesis prospectively to be sure the potential benefit of trastuzumab is not over-estimated in this low-risk patient population.”
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10-10-2009, 01:35 PM
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#2
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Senior Member
Join Date: Oct 2005
Posts: 3,519
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Re: herceptin benefit in those with small (,2cm) node negative her2+ tumors
This is huge! Thanks Lani.
__________________
Brenda
NOV 2012 - 9 yr anniversary
JULY 2012 - 7 yr anniversary stage IV (of 50...)
Nov'03~ dX stage 2B
Dec'03~ Rt side mastectomy, Her2+, ER/PR+, 10 nodes out, one node positive
Jan'04~ Taxotere/Adria/Cytoxan x 6, NED, no Rads, Tamox. 1 year, Arimadex 3 mo., NED 14 mo.
Sept'05~ micro mets lungs/chest nodes/underarm node, Switched to Aromasin, T/C/H x 7, NED 6 months - Herceptin only
Aug'06~ micro mets chest nodes, & bone spot @ C3 neck, Added Taxol to Herceptin
Feb'07~ Genetic testing, BRCA 1&2 neg
Apr'07~ MRI - two 9mm brain mets & 5 punctates, new left chest met, & small increase of bone spot C3 neck, Stopped Aromasin
May'07~ Started Tykerb/Xeloda, no WBR for now
June'07~ MRI - stable brain mets, no new mets, 9mm spots less enhanced, CA15.3 down 45.5 to 9.3 in 10 wks, Ty/Xel working magic!
Aug'07~ MRI - brain mets shrunk half, NO NEW BRAIN METS!!, TMs stable @ 9.2
Oct'07~ PET/CT & MRI show NED
Apr'08~ scans still show NED in the head, small bone spot on right iliac crest (rear pelvic bone)
Sept'08~ MRI shows activity in brain mets, completed 5 fractions/5 consecutive days of IMRT to zap the pesky buggers
Oct'08~ dropped Xeloda, switched to tri-weekly Herceptin in combo with Tykerb, extend to tri-monthly Zometa infusion
Dec'08~ Brain MRI- 4 spots reduced to punctate size, large spot shrunk by 3mm, CT of torso clear/pelvis spot stable
June'09~ new 3-4mm left cerrebellar spot zapped with IMRT targeted rads
Sept'09~ new 6mm & 1 cm spots in pituitary/optic chiasm area. Rx= 25 days of 3D conformal fractionated targeted IMRT to the tumors.
Oct'09~ 25 days of low dose 3D conformal fractionated targeted IMRT to the bone mets spot on rt. iliac crest that have been watching for 2 years. Added daily Aromasin back into treatment regimen.
Apr'10~ Brain MRI clear! But, see new small spot on adrenal gland. Change from Aromasin back to Tamoxifen.
June'10~ Tumor markers (CA15.3) dropped from 37 to 23 after one month on Tamoxifen. Continue to monitor adrenal gland spot. Remain on Tykerb/Herceptin/Tamoxifen.
Nov'10~ Radiate positive mediastinal node that was pressing on recurrent laryngeal nerve, causing paralyzed larynx and a funny voice.
Jan'11~ MRI shows possible activity or perhaps just scar tissue/necrotic increase on 3 previously treated brain spots and a pituitary spot. 5 days of IMRT on 4 spots.
Feb'11~ Enrolled in T-DM1 EAP in Denver, first treatment March 25, 2011.
Mar'11~ Finally started T-DM1 EAP in Denver at Rocky Mountain Cancer Center/Rose on Mar. 25... hallelujah.
"I would rather be anecdotally alive than statistically dead."
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10-10-2009, 05:28 PM
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#3
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Senior Member
Join Date: Sep 2005
Location: Naples FL
Posts: 1,744
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Re: herceptin benefit in those with small (,2cm) node negative her2+ tumors
Yes indeed, this IS huge...as I am in the category discussed!!! My onc prescribed herceptin for me "off label" because it had not yet been approved for early stagers...she felt it was very important in the treatment of early stage Her2 positive breast cancer!!! YAY!!
__________________
 Suzan W.
age 54 at diagnosis
5/05 suspicious mammogram-left breast
5/05 biopsy-invasive lobular carcinoma with LCIS,8mm tumor,stage 1 grade 2, ER+ PR+ Her2+++
6/14/05 bilateral mastectomy, node neg. all scans neg.
Oncotype DX-high risk
8/05-10/05 4 rounds A/C
10/05 -10/06 1 yr. herceptin
arimidex-5 years
2/14/08 started daily self administered injections..FORTEO for severe osteoporosis
7/28/09 BRCA 1 negative BRCA2 POSITIVE
8/17/09 prophylactic salpingo-oophorectomy
10/15/10 last FORTEOinjection
RECLAST infusion(ostoeporosis)
6/14/10 5 year cancerversary!
8/2010-18%increase in bone density!
no further treatments
Oncologist says, "Go do the Happy Dance"
I say,"What a long strange trip its been"
'One day at a time'
6-14-2015. 10 YEAR CANCERVERSARY!
7-16 to 9-16. Extensive (and expensive) dental work done to save teeth. Damage from osteoporosis and chemo and long term bisphosphonate use
6-14-16. 11 YEAR CANCERVERSARY!!
7-20-16 Prolia injection for severe osteoporosis
2 days later, massive hive outbreak. This led to an eventual dx of Chronic Ideopathic Urticaria, an auto-immune disease from HELL.
6-14-17 12 YEAR CANCERVERSARY!!
still suffering from CIU. 4 hospitilizations in the past year
as of today, 10-31-17 in remission from CIU and still, CANCER FREE!!!
6-14-18 13 YEAR CANCERVERSARY!! NED!!
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10-10-2009, 10:38 PM
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#4
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Senior Member
Join Date: Jun 2007
Posts: 2,210
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Re: herceptin benefit in those with small (,2cm) node negative her2+ tumors
Thanks for posting this. What a blessing Herceptin is!
__________________
Bonnie
Post menopause
May 2007 Core biopsy, Rt breast
ER+, Pr-, HER2 +++, Grade 3
Ki-67: 90%
"suspicious area" left breast
Bilateral mastectomy, (NED on left) May 2007
Sentinel Node Neg
Stage 1, DCIS with microinvasion, 3 mm, mostly removed during the biopsy....
Femara (discontinued 7/07) Resumed 10/07
OncoType score 36 (July 07)
Began THC 7/26/07 (d/c taxol and carboplatin 10/07)
Began Herceptin alone 10/07
Finished Herceptin July /08
D/C Femara 4/10 (joint pain/trigger thumb!)
5/10 mistakenly dx with lung cancer. Middle rt lobe removed!
Aromasin started 5/10
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10-11-2009, 03:11 PM
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#5
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Senior Member
Join Date: Mar 2009
Posts: 126
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Re: herceptin benefit in those with small (,2cm) node negative her2+ tumors
Glad to see this  Especially as I go tomorrow to get my every 3 week treatment of H . I will stop complaining about it now....
__________________
Diag. 12/24/08-
IDC 1.3 er-/pr- HER2+
Grade 3 0/2 lymph nodes
no angiolympathic invasion
Bi-Lat. Mast. 1/8/09
Exchange scheduled for 6/17/09
Lost implants due to unknown reason :(
Hip Flap 1/26/2010 in NOLA :) LOVE EM'
TCH x6 (6 done and I am hoping to never do it again )
Well so much for never...
Local recurrence May 25,2014 is left over breast tissue.
April 2 , 2014 lumpectomy
April 28, 2014- June 9, 2014 start AC x 4
Taxol x12
Perjeta x 6
Herceptin x 18
And 33 rads just for fun. NOT!!!
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10-11-2009, 08:20 PM
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#6
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Senior Member
Join Date: Oct 2005
Location: New Jersey
Posts: 3,154
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Re: herceptin benefit in those with small (,2cm) node negative her2+ tumors
Thank you for posting Lani,
I am thrilled to read this. I am glad I did not give up to get herceptin.
jean
__________________
Stage 1, Grade 1, 3/30/05
Lumpectomy 4/15/05 - 6MM IDC
Node Neg. (Sentinel node)
ER+ 90% / PR-, Her2+++ by FISH
Ki-67 40%
Arimidex 5/05
Radiation 32 trt, 5/30/05
Oncotype DX test 4/17/06, 31% high risk
TOPO 11 neg. 4/06
Stopped Arimidex 5/06
TCH 5/06, 6 treatments
Herceptin 5/06 - for 1 yr.
9/06 Completed chemo
Started Femara Sept. 2006
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