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05-02-2008, 08:38 AM
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#1
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Senior Member
Join Date: Sep 2005
Location: Stockton, NJ
Posts: 4,179
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Renee Zellweger to Make Movie on Making of Herceptin
http://www.asco.org/ASCO/News/Cancer...eutersid=10502
Had to post this here for everyone to see! Harry Connick Jr to play Denny Slamon!!!
__________________
Kind regards
Becky
Found lump via BSE
Diagnosed 8/04 at age 45
1.9cm tumor, ER+PR-, Her2 3+(rt side)
2 micromets to sentinel node
Stage 2A
left 3mm DCIS - low grade ER+PR+Her2 neg
lumpectomies 9/7/04
4DD AC followed by 4 DD taxol
Used Leukine instead of Neulasta
35 rads on right side only
4/05 started Tamoxifen
Started Herceptin 4 months after last Taxol due to
trial results and 2005 ASCO meeting & recommendations
Oophorectomy 8/05
Started Arimidex 9/05
Finished Herceptin (16 months) 9/06
Arimidex Only
Prolia every 6 months for osteopenia
NED 18 years!
Said Christopher Robin to Pooh: "You must remember this: You're braver than you believe and stronger than you seem and smarter than you think"
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05-02-2008, 09:01 AM
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#2
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Senior Member
Join Date: Aug 2003
Location: Morris, IL
Posts: 3,507
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Becky
Two of the Dr's from RUSH where I go in Chicago are both good friends of Dr Slamon, & mentioned in the book....The Making of Herceptin...they were a big part of the original clinical trials....Dr Cobleigh and my oncologist, Dr Janet Wolter, Professor of Onc.Rush University Medical Center....
__________________
"Be kinder than necessary, for everyone you meet is fighting some kind of battle."
Hugs & Blessings
Sheila
Diagnosed at age 49.99999 2/21/2002 via Mammography (Calcifications)
Core Biopsy 2/22/02
L. Mastectomy 2/25/2002
Stage 1, 0.7cm IDC, Node Neg from 19 nodes Her2+++ ER PR Neg
6/2003 Reconstruction W/ Tissue Expander, Silicone Implant
9/2003 Stage IV with Mets to Supraclavicular nodes
9/2003 Began Herceptin every 3 weeks
3/2006 Xeloda 2500mg/Herceptin for recurrence to neck nodes
3/2007 Added back the Xeloda with Herceptin for continued mets to nodes
5/2007 Taken Off Xeloda, no longer working
6/14/07 Taxol/Herceptin/Avastin
3/26 - 5/28/08 Taxol Holiday Whopeeeeeeeee
5/29 2008 Back on Taxol w Herceptin q 2 weeks
4/2009 Progression on Taxol & Paralyzed L Vocal Cord from Nodes Pressing on Nerve
5/2009 Begin Rx with Navelbine/Herceptin
11/09 Progression on Navelbine
Fought for and started Tykerb/Herceptin...nodes are melting!!!!!
2/2010 Back to Avastin/Herceptin
5/2010 Switched to Metronomic Chemo with Herceptin...Cytoxan and Methotrexate
Pericardial Window Surgery to Drain Pericardial Effusion
7/2010 Back to walking a mile a day...YEAH!!!!
9/2010 Nodes are back with a vengence in neck
Qualified for TDM-1 EAP
10/6/10 Begin my miracle drug, TDM-1
Mixed response, shrinking internal nodes, progression skin mets after 3 treatments
12/6/10 Started Halaven (Eribulen) /Herceptin excellent results in 2 treatments
2/2011 I CELEBRATE my 9 YEAR MARK!!!!!!!!!!!!!
7/5/11 begin Gemzar /Herceptin for node progression
2/8/2012 Gemzar stopped, Continue Herceptin
2/20/2012 Begin Tomo Radiation to Neck Nodes
2/21/2012 I CELEBRATE 10 YEARS
5/12/2012 BeganTaxotere/ Herceptin is my next miracle for new node progression
6/28/12 Stopped Taxotere due to pregression, Started Perjeta/Herceptin
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05-02-2008, 09:26 AM
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#3
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Senior Member
Join Date: Jan 2007
Location: Thornhill, Ontario
Canada
Posts: 2,320
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That will be one movie
I will be sure to see. This is really exciting, as it will hopefully raise awareness about the necessity to fund breast cancer research so we can get to the cure.
Thanks for posting this Becky - Gee, with Harry Connick Jr. - maybe he'll sing a ballad or two!!
all the best
caya
__________________
ER90%+/PR 50%+/HER 2+
1.7 cm and 1.0 cm.
Stage 1, grade 2, Node Negative (16 nodes tested)
MRM Dec.18/06
3 x FEC, 3 x Taxotere
Herceptin - every 3 weeks for a year, finished May 8/08
Tamoxifen - 2 1/2 years
Femara - Jan. 1, 2010 - July 18, 2012
BRCA1/BRCA2 Negative
Dignosed 10/16/06, age 48 , premenopausal
Mild lymphedema diagnosed June 2009 - breast surgeon and lymph. therapist think it's completely reversible - hope so.
Reclast infusion January 2012
Oopherectomy October 2013
15 Years NED!!
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05-02-2008, 09:38 AM
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#4
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Senior Member
Join Date: Sep 2005
Location: Alaska
Posts: 2,018
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Will watch for it
Interesting, Becky! I look forward to seeing it too. I really, really hope that Zellweger and the others have the freedom to make a very straightforward product.... to me, that would pretty much have to include recognizing and portraying in a deep and meaningful way that there are also those HER2's for whom the drug does not work, so that those individuals are not compromised by the movie.
A.A.
P.S. I wonder who will get to play the dodo's who made things difficult along the way!
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05-02-2008, 10:24 AM
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#5
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Senior Member
Join Date: Oct 2005
Location: New Jersey
Posts: 3,154
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Bravo
Becky,
Thanks for the post....and information.
Any and all awarness is so vital to letting the public understand just what HER2 is and how important herceptin is as a break through drug for those that it does works for....I will speak with Denny and see if I can get some script information for us. Bravo to you my dear friend for posting this.
I think it is a positive movie already, since most people that I have spoken with who have not had breast cancer touch their lives, do not even realize there are different subtypes of breast cancer and so many unknowns...pathways, etc. - let alone what works and does not work. We have a long road ahead of us in this battle of cancer...but with men like Denny - we can hope that drugs are being developed or in the process of being developed to help many of us. I doubt due to the chemistry of each one of us that one big miracle drug will work for all....rather we may need a few...who knows just yet...but awarnees is a major key in our battle. This movie just might help someone who is watching to understand the value of having regular breast exams, many women (hard to believe are afraid to go) this may assist them to understand the importance of early detection...and most of all not to give up, to be aware of the fact that there are many dr. fighting hard along with us in this battle to find a cure.
Each day we get a little bit closer.
Jean
__________________
Stage 1, Grade 1, 3/30/05
Lumpectomy 4/15/05 - 6MM IDC
Node Neg. (Sentinel node)
ER+ 90% / PR-, Her2+++ by FISH
Ki-67 40%
Arimidex 5/05
Radiation 32 trt, 5/30/05
Oncotype DX test 4/17/06, 31% high risk
TOPO 11 neg. 4/06
Stopped Arimidex 5/06
TCH 5/06, 6 treatments
Herceptin 5/06 - for 1 yr.
9/06 Completed chemo
Started Femara Sept. 2006
Last edited by Jean; 05-03-2008 at 01:57 PM..
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05-02-2008, 12:29 PM
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#6
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Senior Member
Join Date: Feb 2006
Location: Southern, CA
Posts: 2,511
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Becky, I was just going to post this very same article but you beat me to it. I'll be looking forward to seeing this. Jean's post covered most of my thoughts on this movie. Well said Jean. That would be great Jean if you could get some of the script from Dr. Slamon. Would be nice to get a sneak peek. They better do a great job with this movie or they will have to answer to the Her2 gang.  Ha!
Chelee
__________________
DX: 12-20-05 - Stage IIIA, Her2/Neu, 3+++,Er & Pr weakly positive, 5 of 16 pos nodes.
Rt. MRM on 1-3-06 -- No Rads due to compromised lungs.
Chemo started 2-7-06 -- TCH - - Finished 6-12-06
Finished yr of wkly herceptin 3-19-07
3-15-07 Lt side prophylactic simple mastectomy. -- Ooph 4-05-07
9-21-09 PET/CT "Recurrence" to Rt. axllia, Rt. femur, ilium. Possible Sacrum & liver? Now stage IV.
9-28-09 Loading dose of Herceptin & started Zometa
9-29-09 Power Port Placement
10-24-09 Mass 6.4 x 4.7 cm on Rt. femur head.
11-19-09 RT. Femur surgery - Rod placed
12-7-09 Navelbine added to Herceptin/Zometa.
3-23-10 Ten days of rads to RT femur. Completed.
4-05-10 Quit Navelbine--Herceptin/Zometa alone.
5-4-10 Appt. with Dr. Slamon to see what is next? Waiting on FISH results from femur biopsy.
Results to FISH was unsuccessful--this happens less then 2% of the time.
7-7-10 Recurrence to RT axilla again. Back to UCLA for options.
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05-02-2008, 10:33 PM
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#7
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Senior Member
Join Date: Nov 2007
Location: Connecticut
Posts: 2,077
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great post, Beck! I hadn't even heard of this! Jean- a sneak peek would be fun. Chelee-yes, they will have to answer to us! Sheila-it would be neat if your docs. were in the movie, too. Caya- (don't tell anyone, but I like that Sinatra-y sound that Connick has, I could work it into the script, He comes home from work at 2:00am lays his keys on the kitchen counter, loosens his tie, and walks to the back patio, and looks across the ocean, waves breaking on the beach, full moon, etc., then goes back in and sits at his piano and starts tinkling the keys, looking sorta melancholy, because at this point, he's still just working on herceptin and has no conclusively positive results. He starts singing low, "when I was a child, I had a dream of something just like you, smiles full of promise, and glittering eyes of gold, we danced across the sand, hand in hand, and promised we'd both grow old, together....." Then his wife, played by Eva Mendez, comes downstairs, and rubs his shoulders as he sits at the piano, "are you ok, honey?" Harry Connick/Dr. Slamon grabs her hand and kisses it and says, "baby, I just feel that we're so close, and these new studies are so promising") Alaska Angel- the number 1 dodo jackass who made things difficult along the way HAS to be played by the same actor who played the Warden in "The Shawshank Redemption" Just thinking too much again. Best wishes, Bill
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05-03-2008, 05:16 AM
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#8
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Senior Member
Join Date: Aug 2006
Location: Sheboygan, WI
Posts: 2,582
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Hahahaha Bill! Good one. Has anyone ever told you that you should be a writer? Well, you should. You've got a gift.
Have a good Saturday everyone.
Mary Jo
__________________
"Be still and know that I am God." Psalm 46:10
Dx. 6/24/05 age 45 Right Breast IDC ER/PR. Neg., - Her2+++ RB Mast. - 7/28/05 - 4 cm. tumor Margins clear - 1 microscopic cell 1 sent. node No Vasucular Invasion 4 DD A/C - 4 DD Taxol & Herceptin 1 full year of Herceptin received every 3 weeks 28 rads prophylactic Mast. 3/2/06
17 Years NED
<>< Romans 8:28
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05-03-2008, 07:56 AM
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#9
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Senior Member
Join Date: Nov 2005
Location: Ireland
Posts: 3,463
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Thanks Becky, I'll be watching out for this one!!
__________________
Tricia
Dx July '05 IDC 1.9cm Triple positive 3/9 nodes positive
A/C X 4 ..Taxol/Herceptin x 12 wks then herceptin 1 yr
Rads x 36 ..oophorectomy August '06
Currently taking Arimidex..
June 2011 osteopenia/ zometa x1 yearly- stopped Zometa 2015 as Dexa show normal bone density.
Stopped Arimidex July 2014- Restarted Arimidex 2015 for a further two years on the advice of my Onc.
2014 Normal Dexa scan
2018 Mammo all clear, still NED!
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05-03-2008, 10:05 AM
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#10
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Senior Member
Join Date: Jan 2007
Location: Thornhill, Ontario
Canada
Posts: 2,320
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Oh Bill, your post made me chuckle, which I needed after this awful week on the boards with sad news everywhere. I love Harry's Sinatra-y voice too, love your lyrics. And I agree about that actor who played the "obtuse" warden in Shawshank...
all the best
caya
__________________
ER90%+/PR 50%+/HER 2+
1.7 cm and 1.0 cm.
Stage 1, grade 2, Node Negative (16 nodes tested)
MRM Dec.18/06
3 x FEC, 3 x Taxotere
Herceptin - every 3 weeks for a year, finished May 8/08
Tamoxifen - 2 1/2 years
Femara - Jan. 1, 2010 - July 18, 2012
BRCA1/BRCA2 Negative
Dignosed 10/16/06, age 48 , premenopausal
Mild lymphedema diagnosed June 2009 - breast surgeon and lymph. therapist think it's completely reversible - hope so.
Reclast infusion January 2012
Oopherectomy October 2013
15 Years NED!!
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05-03-2008, 12:50 PM
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#11
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Senior Member
Join Date: Apr 2008
Location: NY
Posts: 240
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Thanks for the link Becky - I'm so excited about this movie! And Bill - you definitely should try your hand at script-writing (have you already tried it?) The movies today are soooo lame, Hollywood needs your help!
__________________
xxoo
Kathy
2/5/08 - dx age 53, post-menopausal;
IDC Stage 1, Grade 1
ER+ 90% /PR+ 90% /Her2++++, BRAC1 & 2 neg
3/5/08 - mast with muscle-sparing free tram;
0/7 nodes clear; Stage 1 lymphedema in right arm
3/11/08 - MRSA infection in abdomen causes large hernia
4/11/08 - Oncotype DX score 22 (intermediate)
4/12/08 - Muga score 67%
4/23/08 - Chemo, Navelbine and Herceptin every 2 weeks
8/20/08 - Last Navelbine infusion! Yay!
1/22/09 - First mammo since dx - unaffected breast CLEAR!
1/30/09 - Second Muga score 63%
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05-03-2008, 02:49 PM
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#12
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Senior Member
Join Date: Aug 2006
Posts: 3,380
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AllnI want to know is . . .
. . . what does Dr. Slamon think of the casting? Would Harry be his first choice for someone to play him in a movie? 
I look forward to seeing the film. Thanks for posting.
Hopeful |
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05-03-2008, 03:00 PM
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#13
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Senior Member
Join Date: Nov 2004
Location: Misty woods of WA State
Posts: 4,128
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I wonder ...
... who does Renee Z. play? Mrs. Slamon??
__________________
"When I hear music, I fear no danger. I am invulnerable. I see no foe. I am related to the earliest times, and to the latest." H.D. Thoreau
Live in the moment.
MY STORY SO FAR ~~~~
Found suspicious lump 9/2000
Lumpectomy, then node dissection and port placement
Stage IIB, 8 pos nodes of 18, Grade 3, ER & PR -
Adriamycin 12 weekly, taxotere 4 rounds
36 rads - very little burning
3 mos after rads liver full of tumors, Stage IV Jan 2002, one spot on sternum
Weekly Taxol, Navelbine, Herceptin for 27 rounds to NED!
2003 & 2004 no active disease - 3 weekly Herceptin + Zometa
Jan 2005 two mets to brain - Gamma Knife on Jan 18
All clear until treated cerebellum spot showing activity on Jan 2006 brain MRI & brain PET
Brain surgery on Feb 9, 2006 - no cancer, 100% radiation necrosis - tumor was still dying
Continue as NED while on Herceptin & quarterly Zometa
Fall-2006 - off Zometa - watching one small brain spot (scar?)
2007 - spot/scar in brain stable - finished anticoagulation therapy for clot along my port-a-catheter - 3 angioplasties to unblock vena cava
2008 - Brain and body still NED! Port removed and scans in Dec.
Dec 2008 - stop Herceptin - Vaccine Trial at U of W begun in Oct. of 2011
STILL NED everywhere in Feb 2014 - on wing & prayer
7/14 - Started twice yearly Zometa for my bones
Jan. 2015 checkup still shows NED
2015 Neuropathy in feet - otherwise all OK - still NED.
Same news for 2016 and all of 2017.
Nov of 2017 - had small skin cancer removed from my face. Will have Zometa end of Jan. 2018.
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05-03-2008, 03:40 PM
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#14
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Senior Member
Join Date: Oct 2006
Location: Southern California
Posts: 900
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My guess is that Renee Z will play Lilly Tartikoff (wife of the late Brandon Tartikoff) since she played such a huge role in the initial funding for Herceptin research. For those who haven't read the book this is how the Revlon Run/Walk came to be. It is really interesting stuff!
__________________
Gerri
Dx: 11/23/05, Lumpectomy 12/12/05
Tumor 2.2 cm, Stage II, Grade 3, Sentinel Node biopsy negative
ER+ (30%) /PR+ (50%), HER2+++
AC X 4 dose dense, Taxol X 4 dose dense
Herceptin started with 2nd Taxol, given weekly until chemo done
then given every 3 weeks for one year ending on March 16, 2007
Radiation 30 treatments
Tamoxifen - 2 yrs (pre-menopausal)
May 2008 - Feb 2012 Femara
Aug 2008 - Feb 2012 Zometa every 6 months
March 2012 - Stop Femara, now Evista for bone strengthening
********** Enjoy the little things, for one day you may look back and realize they were the big things. - Robert Brault
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05-03-2008, 04:50 PM
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#15
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Senior Member
Join Date: Jan 2007
Location: Massachusetts
Posts: 82
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I read that Zellweger will be producing (only) and not appearing in the film.
__________________
IDC Stage IIIA
Diagnosed Nov 2006 (routine mammogram), age 51
Lumpectomy, lymph node dissection Dec 2006
3 cm tumor, 8 cancerous lymph nodes
Grade 3, ER/PR -, HER-2/neu +++ (by FISH, average 20 copies per cell)
A/C x 4, Taxol x 12, Herceptin x 47 weeks
35 radiation treatments
Completed treatment on April 3, 2008
Chest port removed October 2009
11 years since diagnosis NED
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05-03-2008, 05:01 PM
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#16
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Senior Member
Join Date: Feb 2005
Location: LI, NY
Posts: 660
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I like Bill's idea, but I think that they should work Tiptoe, Stephanie, Christine, Joe and myself meeting Dr. Slamon at the confernce in San Diego!!!!
__________________
Maryann
Stage IV Inflammatory BC 1/00
Mod Rad Mastectomy 24nod/5+
Adriomycin Cytoxin Taxol
Tamoxifen 4 1/2 yrs
Radiation - 32 x
Metastatic BC lung/liver 10/04
thorocentesis 2x - pleurodesis
Herceptin Taxatiere Carbo
Femera/Lupron
BC NED 4/05
chemo induced Acute Myeloid Leukemia 5/06
Induction/consolidation chemo
bone marrow transplant - 11/3/06
Severe Host vs Graft Disease of liver
BC mets to lung 11/07
Fasoladex Herceptin Zometa Xeloda
GVHD/Iron overload to liver
Avascular Necrosis/morphine pump 10/10
metastatic brain tumor
steriotactic radiosurgery
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05-03-2008, 08:49 PM
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#17
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Senior Member
Join Date: Nov 2007
Location: Connecticut
Posts: 2,077
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TY everyone. Madame, that's the best idea yet! (What are you doing up so late??!! You better get to bed. Remember- you gotta get up early in the morning and go rock-and-rollin')
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