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05-31-2007, 08:14 PM
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#1
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Senior Member
Join Date: May 2006
Location: California
Posts: 668
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Great News
I got the BRCA 1,2 yesterday and am negative..Yeah!!!!!
Need no longer to worry about my beautiful daughter... I already called my sisters....They are happy for me. Praise the Lord!!
__________________
1994 - rt brst, .lump, underarm node dissection,chemo+rad 1.2 cms, Grade 3.
28 nodes neg
Er,Pr, Positive HER2 status unknown
2003- Recur to rt lung.July 16 ( B-Day!)
Her2+++ Er,Pr, Negative
2003 - Aug04--Navelbine + Herceptin
2004- 2007--NED - Herceptin, only
2007 Feb-April Xeloda added to hereceptin
2007-May Back on Navelbine+Herceptin
2008-Feb-Mar 15 Ses Rad to Rt. Lung
2008- Oc 17 Add Tykerb to Herceptin
2009- June-- Discont Tykerb
2009 July 7--Current Taxol + Herceptin
2009 Dec--Discontinued treatment due to progression. Looking into cyberknife.
2010-Aug Accepted to TDM1, no SE, except liver count went up.
2010-2011 September got kicked out of the trial, due to a small spot found on lung.
2011- 2012 September thru early 2013 on Herceptin
2013- March Bone density shows small spot on 5th rib.
2013 - April 4th appt with onc. will post after discussing course of treatment.
2013-March-April Cyber knife to brain and radiation to rib. Chest --base line before chemo-CT-Scan stable for lung issue. CA2729 Normal.
2013 April Herceptin- TDMI
2013 Sept Herceptin + Perjeta . CA2729 within normal range. Brain and Pet scans October 31st. will post results.
2013 October Brain MRI- mixed response. Will see Onc/rad on Halloween.
2013 October/November Brain-MRI nothing new. Repeat MRI next year in May.
2013 December Continue Herceptin and Perjeta. Stable at the moment.
2014 February Brain MRI -clear!
2014 January Added Taxotere to Perjeta+Herceptin.
2014 March Stopped chemo-chest ct-scan next.
2014- March Scans shows tumor's larger, CA2729 higher. Discontinue Herceptin.
2014 April Perjeta+ Halaven
2014 April CA2729 went down 60 points after one cycle. Cough does not want to go away.
2014 June Continue on Perjeta + Halaven-- no more cough. Stable
2014 June Back on Herceptin + abraxane
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05-31-2007, 08:35 PM
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#2
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Senior Member
Join Date: Sep 2005
Location: Riverside, CA
Posts: 484
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Adriana, I had that test done about 2 years ago, and I was also negative. I wonder if it has any special meaning for us BC patients, or is it just an indicator that it is not a genetic issue.
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06-01-2007, 12:11 AM
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#3
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Senior Member
Join Date: Feb 2006
Location: Southern, CA
Posts: 2,511
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Big Congratulations! That is excellent news. That must take an extra load off you. Now go out and celebrate. 
Chelee
__________________
DX: 12-20-05 - Stage IIIA, Her2/Neu, 3+++,Er & Pr weakly positive, 5 of 16 pos nodes.
Rt. MRM on 1-3-06 -- No Rads due to compromised lungs.
Chemo started 2-7-06 -- TCH - - Finished 6-12-06
Finished yr of wkly herceptin 3-19-07
3-15-07 Lt side prophylactic simple mastectomy. -- Ooph 4-05-07
9-21-09 PET/CT "Recurrence" to Rt. axllia, Rt. femur, ilium. Possible Sacrum & liver? Now stage IV.
9-28-09 Loading dose of Herceptin & started Zometa
9-29-09 Power Port Placement
10-24-09 Mass 6.4 x 4.7 cm on Rt. femur head.
11-19-09 RT. Femur surgery - Rod placed
12-7-09 Navelbine added to Herceptin/Zometa.
3-23-10 Ten days of rads to RT femur. Completed.
4-05-10 Quit Navelbine--Herceptin/Zometa alone.
5-4-10 Appt. with Dr. Slamon to see what is next? Waiting on FISH results from femur biopsy.
Results to FISH was unsuccessful--this happens less then 2% of the time.
7-7-10 Recurrence to RT axilla again. Back to UCLA for options.
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06-01-2007, 04:05 AM
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#4
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Senior Member
Join Date: Aug 2006
Location: Sheboygan, WI
Posts: 2,582
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Adriana,
I'm happy for you too. That must have felt like a huge weight lifted. Thanks for sharing.
Mary Jo
__________________
"Be still and know that I am God." Psalm 46:10
Dx. 6/24/05 age 45 Right Breast IDC ER/PR. Neg., - Her2+++ RB Mast. - 7/28/05 - 4 cm. tumor Margins clear - 1 microscopic cell 1 sent. node No Vasucular Invasion 4 DD A/C - 4 DD Taxol & Herceptin 1 full year of Herceptin received every 3 weeks 28 rads prophylactic Mast. 3/2/06
17 Years NED
<>< Romans 8:28
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06-01-2007, 05:31 AM
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#5
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Senior Member
Join Date: Aug 2003
Location: Morris, IL
Posts: 3,507
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Adriana
I am so happy for you....each piece of good news is savored by all of us.
Lots of Love
__________________
"Be kinder than necessary, for everyone you meet is fighting some kind of battle."
Hugs & Blessings
Sheila
Diagnosed at age 49.99999 2/21/2002 via Mammography (Calcifications)
Core Biopsy 2/22/02
L. Mastectomy 2/25/2002
Stage 1, 0.7cm IDC, Node Neg from 19 nodes Her2+++ ER PR Neg
6/2003 Reconstruction W/ Tissue Expander, Silicone Implant
9/2003 Stage IV with Mets to Supraclavicular nodes
9/2003 Began Herceptin every 3 weeks
3/2006 Xeloda 2500mg/Herceptin for recurrence to neck nodes
3/2007 Added back the Xeloda with Herceptin for continued mets to nodes
5/2007 Taken Off Xeloda, no longer working
6/14/07 Taxol/Herceptin/Avastin
3/26 - 5/28/08 Taxol Holiday Whopeeeeeeeee
5/29 2008 Back on Taxol w Herceptin q 2 weeks
4/2009 Progression on Taxol & Paralyzed L Vocal Cord from Nodes Pressing on Nerve
5/2009 Begin Rx with Navelbine/Herceptin
11/09 Progression on Navelbine
Fought for and started Tykerb/Herceptin...nodes are melting!!!!!
2/2010 Back to Avastin/Herceptin
5/2010 Switched to Metronomic Chemo with Herceptin...Cytoxan and Methotrexate
Pericardial Window Surgery to Drain Pericardial Effusion
7/2010 Back to walking a mile a day...YEAH!!!!
9/2010 Nodes are back with a vengence in neck
Qualified for TDM-1 EAP
10/6/10 Begin my miracle drug, TDM-1
Mixed response, shrinking internal nodes, progression skin mets after 3 treatments
12/6/10 Started Halaven (Eribulen) /Herceptin excellent results in 2 treatments
2/2011 I CELEBRATE my 9 YEAR MARK!!!!!!!!!!!!!
7/5/11 begin Gemzar /Herceptin for node progression
2/8/2012 Gemzar stopped, Continue Herceptin
2/20/2012 Begin Tomo Radiation to Neck Nodes
2/21/2012 I CELEBRATE 10 YEARS
5/12/2012 BeganTaxotere/ Herceptin is my next miracle for new node progression
6/28/12 Stopped Taxotere due to pregression, Started Perjeta/Herceptin
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06-01-2007, 12:24 PM
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#6
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Senior Member
Join Date: Oct 2005
Location: LAND OF YES!
w/home in Boca Raton, Florida
Orig from L.I., N.Y.
Ever hovering IN THE NOW...
Posts: 1,904
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BRCA 1 & 2
First, Yeah Adriana -- negative! I have 2 beautiful daughters and 2 magnificent granddaughters and my negative news (Sept '06, 11 yrs after being diagnosed initially) was a cause for elation. Had it been pos, I would be faced w/doing another mastec and hysterec, my doc said, the chance of recurrence being that strong. As well, my daughter, granddghters, sister and niece can breath a great sigh of relief. There chances of getting the gene would be enormous if pos. I have read twice that the HER2+ gene is not hereditary, which is also encouraging. My dghtrs are 37 and 39. They had base line mammog in early 30's, when I was initially dx. Now my 39 yr old is going to begin her annual mammog. They self examine ev mnth. "I" NEVER HAD A LUMP! Mine was lobular. My entire left breast felt "spongey", weird, harder than usual. I was turning 50. Had my Aug mammog (which showed NOTHING), thought this new thing was perhaps part of getting older. Always examined myself for lumps, peas, marbles. This was maybe a cyst I thought. Would need surgery to remove. Never that cancer. But would attend to it when I returned from Fla winter to NY. Moved my mammog up to early July. Went to GYN. The rest is history. NO ONE EVER ADVERTISED THAT BC COULD LOOK AND FEEL LIKE THIS (9cm hardness). PEAS and MARBLES I thought. (I've since been told by a wonderful woman radiol that they hate lobular. IT HIDES. YOU CAN'T SEE IT ON MAMMOG. YOU CAN'T REALLY FEEL IT -- UNTIL IT'S HUGE. And therefore, advanced. Which meant I had 4th stage infiltrating lobular carcinoma + 2 nodes and needed a mastec, reconst and chemo. Then the Her2+ thing came (betw '95 and '98 when I had multiple mets into the liver).
By the way, it was ME who questioned 3 sets of ev 3 mnth comprehensive bld tests showing "VERY slightly elevated liver enzymes. I wouldn't worry about it" 2 diff docs said. I finally said I AM WORRIED. I WANT A "LIVER SONOGRAM". You mean an abdominal sono. I guess we could justify that. Okay. Then the radiol said after looking and looking -- I'm really sorry but I have to send you for a CT scan to get a better look. I'm not sure what I am looking at. Then the scan. Then the biop. Found by ME! With 3 or 4 docs on the job. All brilliant. LET THAT BE A CAUTIONARY TALE. We must be proactive, involved and on the case! Stay strong all... With loving energy, ANDI
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