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Old 10-02-2006, 07:53 PM   #1
hmerch
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Join Date: Apr 2006
Posts: 5
Sunitinab?

Has anyone ever heard of this drug Sunitinab? My mother has brain mets and has already undergone WBR. The mets came back within a few months of WBR. She is currently on Gemzr+Carboplatinum and herceptin.

We were looking to see if we could get her on Lapatinib when 1 oncologist (a friend of a Dr that we know) mentioned that Sunitinab was an option we should consider. I have never heard of this drug.

Has anyone else heard or used it?

Thanks,
Hina

PS - My brother Shahyan posts on this site too about our mother.
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Old 10-02-2006, 08:09 PM   #2
chrisy
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Join Date: Sep 2005
Location: Central Coast, CA
Posts: 3,207
This is Sutent

I think the actual spelling of this is sunitinib?

It is FDA approved for gastrointestinal stromal cancer and renal cell cancer, but is also in trials for other cancers including metastatic breast cancer.

Here is a link to a press release on it, sort of old, but it may help you find more info.

http://www.pfizer.ca/english/newsroo...&releaseID=167


I really know nothing about this drug, but perhaps it is a small molecule and may cross the blood-brain barrier which might be why your mother's oncologist is considering it.

Good luck, hang in there
__________________
Chris in Scotts Valley
June 2002 extensive hi grade DCIS (pre-cancer-stage 0, clean sentinal node) Mastectomy/implant - no chemo, rads. "cured?"
9/2004 Diag: Stage IV extensive liver mets (!) ER/PR- Her2+++
10/04-3/05 Weekly Taxol/Carboplatin/Herceptin , complete response!
04/05 - 4/07 Herception every 3 wks, Continue NED
04/07 - recurrence to liver - 2 spots, starting tykerb/avastin trial
06/07 8/07 10/07 Scans show stable, continue on Tykerb/Avastin
01/08 Progression in liver
02/08 Begin (TDM1) trial
08/08 NED! It's Working! Continue on TDM1
02/09 Continue NED
02/10 Continue NED. 5/10 9/10 Scans NED 10/10 Scans NED
12/10 Scans not clear....4/11 Scans suggest progression 6/11 progression confirmed in liver
07/11 - 11/11 Herceptin/Xeloda -not working:(
12/11 Begin MM302 Phase I trial - bust:(
03/12 3rd times the charm? AKT trial

5/12 Scan shows reduction! 7/12 More reduction!!!!
8/12 Whoops...progression...trying for Perjeta/Herceptin (plus some more nasty chemo!)
9/12 Start Perjeta/Herceptin, chemo on hold due to infection/wound in leg, added on cycle 2 &3
11/12 Poops! progression in liver, Stop Perjeta/Taxo/Herc
11/12 Navelbine/Herce[ptin - try for a 3 cycles, no go.
2/13 Gemzar/Carbo/Herceptin - no go.
3/13 TACE procedure
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