Her-2 and er+

http://www.asco.org/ac/1,1003,_12-002636-0...9-001353,00.asp

"over-expression of HER2/neu is a significantly unfavorable prognostic factor for RFS in steroid receptor positive patients(log-rank test, p=0.0011), but not ER and PR negative patients."

[Lolly]

Rich, apparently it's a method of computing statistics. Here's an excerpt from a site I found:



Intuitive Biostatistics: Comparing Two Survival Curves

"... It is common to compare two survival curves, to compare two treatments. Compare two survival curves using the log-rank test. This test calculates a P value testing the null hypothesis that the survival curves are identical in the two populations. If that assumption is true, the P value is the probability of randomly selecting subjects whose survival curves are as different (or more so) than was actually observed. (You will sometimes see survival curves compared with the method of Mantel-Haenszel, rather than the log-rank test. The two methods are essentially equivalent.)..."

Here is another,
Al

Log-Rank Survival Tests (Simple and Advanced)
The log-rank survival test compares two survival distributions. The simple procedure is very easy to specify because time values are not used. The advanced procedure compares survival across the whole spectrum of time, not just at one or two points. These PASS modules allows the sample size and power of the log-rank test to be analyzed under very general conditions.

What I get from this is that in Node negative BC that is er+, her 2 positive status is a significant prognostic (sp?) factor? But not in er-?

What does steroid receptor positive mean?