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09-21-2011, 04:45 PM
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#1
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Senior Member
Join Date: Mar 2010
Location: Mechanicsburg, OH
Posts: 109
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Liver dysfunction
My family Dr. called today after I had a regular check up with him with a complete CBC and he said my liver numbers were high so he has ordered an ultrasound for next Tues. I had a check up the end of August with my Onc. and all my tumor markers were good...is this how liver mets. is found? Anyone else have this happen? I'm still on Tamoxifin but have finished up all my other treatments. Knew someone here may have a similar experience, thanks in advance for any input. Of corse my mind immediately went to Mets. although I guess that is a normal reaction.
__________________
~Anna
DX April 2009 age 40
IDC Triple Positive
7 of 14 nodes positive
Lumpectomy May 2009
Port May 2009
AC done in Sept 2009
T done Dec. 2009
Herceptin (should finish Oct. 2010)
Mastectomy January 2010
Radiaition x 33 done April 2010
Tamoxafin for five years
Herceptin done!
Still clear May 2011
3 years out May 2012, all good!
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09-22-2011, 03:17 AM
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#2
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Senior Member
Join Date: Mar 2010
Location: Mechanicsburg, OH
Posts: 109
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Re: Liver dysfunction
Just bumping this up, didn't get any replies last night. Have a good day!
__________________
~Anna
DX April 2009 age 40
IDC Triple Positive
7 of 14 nodes positive
Lumpectomy May 2009
Port May 2009
AC done in Sept 2009
T done Dec. 2009
Herceptin (should finish Oct. 2010)
Mastectomy January 2010
Radiaition x 33 done April 2010
Tamoxafin for five years
Herceptin done!
Still clear May 2011
3 years out May 2012, all good!
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09-22-2011, 05:59 AM
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#3
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Senior Member
Join Date: Feb 2007
Location: Paris, France
Posts: 858
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Re: Liver dysfunction
Hello Anna. An elevation of liver numbers can have all kinds of reasons but your doctor is right to investigate.
When my mets were discovered, all my liver parameters were normal. It is a slight raise of my CA15-3 markers that led to investigate with a Pet/scan. You have a good doctor. He just wants to check everything. Michka
__________________
08.2006 3 cm IDC Stage 2-3, HER2 3+ ER+90% PR 20%
FEC, Taxol+ Herceptin, Mastectomy, Radiation, Herceptin 1 year followed by Tykerb 1 year,Aromasin /Faslodex
12.2010 Mets to liver,Herceptin+Tykerb
03.2011 Liver resection ER+70% PR-
04.2011 Herceptin+Navelbine+750mg Tykerb
06.2011 Liver ned, Met to sternum. Added Zometa 09.2011 Cyberknife for sternum
11.2011 Pet clear. Stop Navelbine, continuing on Hercpetin+Tykerb+Aromasin
02.2012 Mets to lungs, nodes, liver
04.2012 TDM1, Ned in 07.2012
04.2015 Stop TDM1/Kadcyla, still Ned, liver problems
04.2016 Liver mets. Back on Kadcyla
08.2016 Kadcyla stopped working. mets to liver lungs bones
09.2016 Biopsy to liver. no more HER2, still ER+
09.2016 CMF Afinitor/Aromasin/ Xgeva.Met to eye muscle Cyberknife
01.2017 Gemzar/Carboplatin/ Ibrance/Faslodex then Taxotere
02.2017 30 micro mets to brain breathing getting worse and worse
04.2017 Liquid biopsy/CTC indicates HER2 again. Start Herceptin with Halaven
06.2017 all tumors shrunk 60% . more micro mets to brain (1mm mets) no symptoms
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09-22-2011, 11:16 AM
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#4
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Senior Member
Join Date: Apr 2011
Posts: 403
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Re: Liver dysfunction
My nurse said liver numbers can go up during treatment. My oncologist said a slight elevations do not cause concern. Now that you are 2 years out, you may wanna detoxify your liver from all the chemo drug. I know milk thistle is an easy one. Good luck with everything 
__________________
1/11 age 36 DX
ER/PR-, Her2 +
TCH*6, Herceptin
BMX with immediate recontruction 5/2011 Lattismus Flap- Dx stage 3c 10/23 nodes
9/11 Radiation
3/12 Local recurrence to skin stage IV
Whole body scan CLEAR
4/12 Tykerb & Xeolda Skin mets slowly regressing
8/12 PET & Brain CT Clear
5/13 Skin mets progressing
6/13 PET scan chestwall recurrence in contralateral anxillary,internal mammary and ipsilateral subpectoral nodes
6/13 kadcyla
10/13 whole body scan -clear NED. previously resolved skin rash gone but 3 new lesions. Biopsy confirmed for skin recurrence
11/13 to 02/14 tykerb & herceptin
02/14 add abraxane/gemzar, 2 weeks on 1 week off at reduced dose
05/14 whole body PET clear/ brain CT clear but skin mets are getting worse, ready for new chemo
05/14 navelbine perjeta herceptin
07/14 skin mets progressing red rash worse
08/14 wide local excision with diep flap to close wound. Final path shows 2 positive margins showing inflammatory carcinoma Going back to surgery in 2 weeks
09/01/14 resection- clear margins
3 weeks after 2nd surgery, a new nodular rash found near drain incision with 2 small red spots behind the chest wall biopsy on 10/1. Positive for breast cancer
Radiation 11/2014 with xeloda then weekly cisplatin
11/14 brain MRI clean
12/14 finished 33 radiations burnt and very painful. Bedridden for 1 week
12/14 t current Herceptin and perjeta only
02/15 rash on upper back right side skin mets radiation planned
02/15 staring electron radiation *35
Stopped at 30 due to severe skin burn, resumed 10 days later
05/15 red patches appeared in between previously radiated area, skin mets. Ct and brain Mri clear. Simulation planned, radiation to start after trip to Alaska.
05/24 new spot identified in scar line on previously radiated reconstructed breast- electron on both side chest wall area and scar line
07/15 multiple skin and lung recurrence begin halaven
11/15 cough much better but very tired on halaven and starting to see some new red skin blotches-suspicious
11/15 heading to China for immune therapy
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09-22-2011, 06:42 PM
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#5
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Senior Member
Join Date: Mar 2010
Location: Mechanicsburg, OH
Posts: 109
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Re: Liver dysfunction
Talked to my onc. today and although he is not too concerned with my numbers he would rather I do a CT scan instead of the ultrasound. His thinking is if the ultrasound shows nothing I'm still going to be concerned and will end up wanting a scan so why not just do it from the get go. I go Monday afternoon.
I will check into the Milk Thistle...thanks for the input.
__________________
~Anna
DX April 2009 age 40
IDC Triple Positive
7 of 14 nodes positive
Lumpectomy May 2009
Port May 2009
AC done in Sept 2009
T done Dec. 2009
Herceptin (should finish Oct. 2010)
Mastectomy January 2010
Radiaition x 33 done April 2010
Tamoxafin for five years
Herceptin done!
Still clear May 2011
3 years out May 2012, all good!
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09-22-2011, 07:02 PM
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#6
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Senior Member
Join Date: Aug 2009
Location: Moultrie, GA
Posts: 431
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Re: Liver dysfunction
Anna,
The same thing happened to me when I was two years out. My liver numbers were slightly elevated and my onc had me come back for a scan. Everything was OK. But, I wanted to let you know what I discovered. My extra vitamin D caused the elevation. After my doctor became alarmed, I thought and thought about what could be causing the higher liver numbers. I ruled out Tylenol and alcohol and then learned that vitamins are broken down in the liver. I quit all vitamins and my next liver tests decreased by 50%! I just wanted to share this with you in case you are over-loading on what is usually a good thing!
Sandra
__________________
Diagnosed: 7/25/08 ~ age 63, no family history
Surgery: 8/14/08 Bilateral mastectomy; tumor left breast, node dissection; right prophylactic with expanders: 1/12/10 latisimuss dorsi flap on left side: 9/22/10 implants in
Pathology Report: ER/PR-; HER2+ (3+); Grade 3, StageIII; 3cm tumor plus 21/21 lymph nodes positive; 5cm DCIS
Chemo: A/C; Taxol/Herceptin/Tykerb; phase II study at Mayo adding Tykerb for early stage
Radiation: 25 rads
Vaccine: Walter Reed GP2/AE37 vaccine study ~ last booster 9/17/2012
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09-22-2011, 07:11 PM
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#7
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Senior Member
Join Date: Mar 2010
Location: Mechanicsburg, OH
Posts: 109
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Re: Liver dysfunction
Sandra, oh my...I do take vitamins daily...guess I need to look into that. Thanks!
Yanyan, just looked up milk thistle and it sounded okay until I read about the estrogen...I am ER/PR+ so this may not be for me, thanks anyway.
__________________
~Anna
DX April 2009 age 40
IDC Triple Positive
7 of 14 nodes positive
Lumpectomy May 2009
Port May 2009
AC done in Sept 2009
T done Dec. 2009
Herceptin (should finish Oct. 2010)
Mastectomy January 2010
Radiaition x 33 done April 2010
Tamoxafin for five years
Herceptin done!
Still clear May 2011
3 years out May 2012, all good!
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09-22-2011, 07:50 PM
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#8
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Senior Member
Join Date: Jan 2008
Location: Virginia
Posts: 116
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Re: Liver dysfunction
Hey just wanted to say I also had elevated liver enzymes two years out from treatment. It turns out everything was fine and my oncologist said tamoxifin or arimidix can cause elevated liver enzymes in about 2% of patients. My numbers are still evevated at times.
Best Wishes - Melissa
__________________
Melissa
04/06, (42), 2cm tumor, 7/13 nodes, one positive node under clavicle
mastectomy/reconstruction
grade 3, stage lllb, er-65+, pr-90+, her2+++(80%)
4/AC, 12wks TH then 6wks rads
40 wks herceptin, and tamoxifen.
onc test tamoxifen resistance = poor metabilizer
04/07 ooph & on arimidex
08/07 completed herceptin
04/2022 - 16 year survivor!
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09-22-2011, 08:41 PM
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#9
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Senior Member
Join Date: May 2006
Posts: 3,142
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Re: Liver dysfunction
If you do not want to take milk thistle there are some foods that may help detoxify the liver.
I think Kale, broccoli, beets and bittermelon are some of those foods. You might also want to do an internet search and find more.
Take care.
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09-23-2011, 10:54 AM
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#10
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Senior Member
Join Date: May 2006
Posts: 3,142
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Re: Liver dysfunction
Just a note---------- I went to the livestrong website after I logged off here yesterday and looked up foods to detox the liver. I found onions, leeks, shallots, tumeric and of course crucifious vegetables like broccoli, and other crucifious vegetables.
We could make a detox salad, soup or detox stir fry !!!!!!!!! Lovely !!!!!!
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09-23-2011, 11:11 AM
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#11
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Senior Member
Join Date: Sep 2005
Location: Central Coast, CA
Posts: 3,207
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Re: Liver dysfunction
Don't forget the carrots
__________________
Chris in Scotts Valley
June 2002 extensive hi grade DCIS (pre-cancer-stage 0, clean sentinal node) Mastectomy/implant - no chemo, rads. "cured?"
9/2004 Diag: Stage IV extensive liver mets (!) ER/PR- Her2+++
10/04-3/05 Weekly Taxol/Carboplatin/Herceptin , complete response!
04/05 - 4/07 Herception every 3 wks, Continue NED
04/07 - recurrence to liver - 2 spots, starting tykerb/avastin trial
06/07 8/07 10/07 Scans show stable, continue on Tykerb/Avastin
01/08 Progression in liver
02/08 Begin (TDM1) trial
08/08 NED! It's Working! Continue on TDM1
02/09 Continue NED
02/10 Continue NED. 5/10 9/10 Scans NED 10/10 Scans NED
12/10 Scans not clear....4/11 Scans suggest progression 6/11 progression confirmed in liver
07/11 - 11/11 Herceptin/Xeloda -not working:(
12/11 Begin MM302 Phase I trial - bust:(
03/12 3rd times the charm? AKT trial
5/12 Scan shows reduction! 7/12 More reduction!!!!
8/12 Whoops...progression...trying for Perjeta/Herceptin (plus some more nasty chemo!)
9/12 Start Perjeta/Herceptin, chemo on hold due to infection/wound in leg, added on cycle 2 &3
11/12 Poops! progression in liver, Stop Perjeta/Taxo/Herc
11/12 Navelbine/Herce[ptin - try for a 3 cycles, no go.
2/13 Gemzar/Carbo/Herceptin - no go.
3/13 TACE procedure
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09-23-2011, 01:54 PM
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#12
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Senior Member
Join Date: Apr 2011
Location: Michigan
Posts: 1,173
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Re: Liver dysfunction
Anna, Gods blessings to you and your family. Please know you are in my prayers!
__________________
dx 11/12/09 IDCI
Stage 3a
ER 98% PR 80%
Her2 +3
4/12 nodes
6 rounds TCH
Herceptin 12 months 3weeks
Rad. 30 tx
Tamoxifin 6 months stopped
Arimedex stopped 9/12 (side effects)
Aromasin 10/12
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09-23-2011, 02:44 PM
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#13
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Senior Member
Join Date: Mar 2010
Location: Mechanicsburg, OH
Posts: 109
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Re: Liver dysfunction
Thanks again for all the helpful information and for the prayers, I will let you know how my scan goes. Have a great weekend~
__________________
~Anna
DX April 2009 age 40
IDC Triple Positive
7 of 14 nodes positive
Lumpectomy May 2009
Port May 2009
AC done in Sept 2009
T done Dec. 2009
Herceptin (should finish Oct. 2010)
Mastectomy January 2010
Radiaition x 33 done April 2010
Tamoxafin for five years
Herceptin done!
Still clear May 2011
3 years out May 2012, all good!
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10-02-2011, 05:39 PM
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#14
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Senior Member
Join Date: Mar 2010
Location: Mechanicsburg, OH
Posts: 109
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Re: Liver dysfunction
Just wanted to let everyone know that scans came back clean...yeah! Praise the Lord. I will go for more blood work in a month to see if numbers are still high. In the meantime I've cut out some of my vitamins and will look into cleansing my liver with some healthy foods. Could just be the Tamoxifin. Thanks for the many prayers.
__________________
~Anna
DX April 2009 age 40
IDC Triple Positive
7 of 14 nodes positive
Lumpectomy May 2009
Port May 2009
AC done in Sept 2009
T done Dec. 2009
Herceptin (should finish Oct. 2010)
Mastectomy January 2010
Radiaition x 33 done April 2010
Tamoxafin for five years
Herceptin done!
Still clear May 2011
3 years out May 2012, all good!
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10-02-2011, 06:12 PM
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#15
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Senior Member
Join Date: Jun 2007
Posts: 2,210
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Re: Liver dysfunction
Or it could just have been a bump in the road. I had some elevated numbers recently because a different lab ran the test differently. We redid the lab work and it was fine.
Keep the faith.
__________________
Bonnie
Post menopause
May 2007 Core biopsy, Rt breast
ER+, Pr-, HER2 +++, Grade 3
Ki-67: 90%
"suspicious area" left breast
Bilateral mastectomy, (NED on left) May 2007
Sentinel Node Neg
Stage 1, DCIS with microinvasion, 3 mm, mostly removed during the biopsy....
Femara (discontinued 7/07) Resumed 10/07
OncoType score 36 (July 07)
Began THC 7/26/07 (d/c taxol and carboplatin 10/07)
Began Herceptin alone 10/07
Finished Herceptin July /08
D/C Femara 4/10 (joint pain/trigger thumb!)
5/10 mistakenly dx with lung cancer. Middle rt lobe removed!
Aromasin started 5/10
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10-03-2011, 05:28 AM
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#16
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Senior Member
Join Date: Aug 2011
Location: Philly Suburbs
Posts: 1,709
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Re: Liver dysfunction
Yay!
So glad everything checked out fine!
(I've been following the thread, but until now, I had nothing useful to add. LOL)
Be well!
Denise
__________________
1/11-needle biopsy
2/11-Lumpectomy/axillary node dissection - Stage 3c, ER/PR-14/17 nodes
3/11 - Post-op staph infection,cellulitis, lymphedema,seroma,ARRRGH!
4/12/11-A/C x 4, then T/H x 4, H only,Q3 weeks
8/26/11 finished Taxol!!!
10/7/11 mastectomy/DIEP recon
11/11 radiation x28
1/12/12 1st CANCER-VERSARY!
1/12 Low EF/Herceptin "Holiday" :(
2/12 EF up - Back on Herceptin, heart meds
4/2/1212 surgery to repair separated incision from DIEP recon
6/8/12 Return to work :)
6/17/12 Fall, shatter wrist,surgery to repair/insert plate :(
7/10/12 last Herceptin
7/23/12 Brain Mets %$&#! 3cm and 1cm
8/10/12 Gamma knife surgery, LOTS of steroids;start H/Tykerb
8/23/12 Back to work
12/20/12 Injure back-3 weeks in wheel chair
1/12/13 2nd CANCER-VERSARY!
1/14/13 herniate disk in back - surgery to repair
1/27/13 Radiation necrosis - edema in brain - back on steroids - but not back to work - off balance, poor cordination in right arm
5/3/13 Start Avastin to shrink necrosis
5/10/13 begin weaning steroids
6/18/13 Brain MRI - Avastin seems to be working!
6/20/13 quarterly CT - chest, abdomen, pelvis - All Clear!
7/5/13 finally off steroids!!
7/7/13 joined the ranks of the CHEMO NINJAS I am now Tekuto Ki Ariku cancer assassin!
7/13/13 Symptoms return - back on steroids
7/26/13 Back on Avastin - try again!
8/26/13 Not ready to return to classroom yet :( But I CAN walk without holding onto things! :)
9/9/13 Brain MRI - fingers crossed
“ Life is a grindstone, and whether it grinds you down or polishes you up is for you, and you alone, to decide. ” – Cavett Robert
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10-03-2011, 10:16 AM
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#17
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Senior Member
Join Date: Feb 2007
Location: Paris, France
Posts: 858
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Re: Liver dysfunction
This is good news Anna! Michka
__________________
08.2006 3 cm IDC Stage 2-3, HER2 3+ ER+90% PR 20%
FEC, Taxol+ Herceptin, Mastectomy, Radiation, Herceptin 1 year followed by Tykerb 1 year,Aromasin /Faslodex
12.2010 Mets to liver,Herceptin+Tykerb
03.2011 Liver resection ER+70% PR-
04.2011 Herceptin+Navelbine+750mg Tykerb
06.2011 Liver ned, Met to sternum. Added Zometa 09.2011 Cyberknife for sternum
11.2011 Pet clear. Stop Navelbine, continuing on Hercpetin+Tykerb+Aromasin
02.2012 Mets to lungs, nodes, liver
04.2012 TDM1, Ned in 07.2012
04.2015 Stop TDM1/Kadcyla, still Ned, liver problems
04.2016 Liver mets. Back on Kadcyla
08.2016 Kadcyla stopped working. mets to liver lungs bones
09.2016 Biopsy to liver. no more HER2, still ER+
09.2016 CMF Afinitor/Aromasin/ Xgeva.Met to eye muscle Cyberknife
01.2017 Gemzar/Carboplatin/ Ibrance/Faslodex then Taxotere
02.2017 30 micro mets to brain breathing getting worse and worse
04.2017 Liquid biopsy/CTC indicates HER2 again. Start Herceptin with Halaven
06.2017 all tumors shrunk 60% . more micro mets to brain (1mm mets) no symptoms
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10-09-2011, 01:18 AM
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#18
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Senior Member
Join Date: Mar 2007
Location: Hilo, Hawaii
Posts: 1,867
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Re: Liver dysfunction
Anna, how high were your numbers? My labs always come back with my bilirubin indirect and bilirubin total just above the normal range. My onco and internist are both fine with this and attribute it to something like Gilbert's syndrome, which is a genetic high genetically high amt of bilirubin and is not necessary to treat. you can google it for a better discription.
__________________
*** MARYANNE *** aka HARRIECANARIE
1993: right side DCIS, lumpectomy, rads
1999: left side DCIS, lumpectomy, rads, tamoxifen
2006:
BRCA 2 positive
Stage I, invasive DCIS (6mm x 5mm)
Grade: intermediate
sentinal node biopsy: neg
HER2/neu amplified 4.7
ER+/PR+
TOPO II neg
Oncotype dx 20
Bilat mastectomy with DIEP flap reconstruction
oophorectomy
2007:
6 cycles TCH (taxotere, carboplatin, herceptin)
finished 1 yr herceptin 05/07
Arimidex, stopped after almost 1 yr
Femara
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