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04-18-2012, 08:23 AM
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#1
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Senior Member
Join Date: Apr 2012
Posts: 87
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Breast cancer mets to Uterus
My wife just found out recently that her breast cancer has spread again to her uterus which I understand is very rare. Her oncologist said in 20 years that this is the first time he has had a patient experience this particular metastasis. I have found very little information online. Has anyone else experienced this or know of anyone else who has?
I posted this on the newcomer forum but then thought maybe this one gets read more frequently.
Thanks,
Greg
08/03/10 ~ Dx Inflammatory Breast Cancer, Her2+++ ER-/PR- Stage 4, mets to liver. Age 43.
08/27/10 ~ Began 12 weeks of Taxetere/Carboplatin/Herceptin tx.
10/25/10 ~ Scans show liver lesion is gone.NED! 
11/19/10 ~ Ended chemo. Continued with Herceptin-only tx every 3 weeks.
01/31/11 ~ Mastectomy
03/07/11 ~ Radiation
07/06/11 ~ Reconstructive surgery
10/10/11 ~ Annual PET/CT scan shows still NED!
01/20/12 ~ Malignant tumors found in uterus, cervix, fallopian tubes and lymph nodes. Initially misdiagnosed as endometrial cancer.
02/01/12 ~ Hysterectomy(all "visible" tumors removed).
02/10/12 ~ Final Herceptin treatment.
03/09/12 ~ Begain Cisplatin/Adriamycin tx for endometrial cancer.
03/20/12 ~ Tumors dx to be breast cancer metastisis, not entdometrial cancer. Back to bc tx.
04/07/12 ~ Got married in Jamaica.
04/10/12 ~ Began Tykerb/Xeloda tx. 5 Tykerb, 6 Xeloda. Three cycles Xeloda - two weeks on/one week off.
06/12 ~ PET/CT scans scheduled |
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04-18-2012, 09:39 AM
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#2
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Senior Member
Join Date: Apr 2011
Posts: 403
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Re: Breast cancer mets to Uterus
Hi, Greg. Congratulations on getting married ! I think although mets from BC to uterus is rare, it does happen. I know a lady in another support group who had mets to ovary. She had hysterectomy as well and it has been 4 or 5 years she is doing fine. I see your wifes current treatment is tykerb and xeloda- i am also on this drug, started on April 10 for local skin recurrence. I heard this drug works great for many people. Hopefully this will work for your wife as well ! I have learned to deal with cancer as a chronic diseases. Good luck !
__________________
1/11 age 36 DX
ER/PR-, Her2 +
TCH*6, Herceptin
BMX with immediate recontruction 5/2011 Lattismus Flap- Dx stage 3c 10/23 nodes
9/11 Radiation
3/12 Local recurrence to skin stage IV
Whole body scan CLEAR
4/12 Tykerb & Xeolda Skin mets slowly regressing
8/12 PET & Brain CT Clear
5/13 Skin mets progressing
6/13 PET scan chestwall recurrence in contralateral anxillary,internal mammary and ipsilateral subpectoral nodes
6/13 kadcyla
10/13 whole body scan -clear NED. previously resolved skin rash gone but 3 new lesions. Biopsy confirmed for skin recurrence
11/13 to 02/14 tykerb & herceptin
02/14 add abraxane/gemzar, 2 weeks on 1 week off at reduced dose
05/14 whole body PET clear/ brain CT clear but skin mets are getting worse, ready for new chemo
05/14 navelbine perjeta herceptin
07/14 skin mets progressing red rash worse
08/14 wide local excision with diep flap to close wound. Final path shows 2 positive margins showing inflammatory carcinoma Going back to surgery in 2 weeks
09/01/14 resection- clear margins
3 weeks after 2nd surgery, a new nodular rash found near drain incision with 2 small red spots behind the chest wall biopsy on 10/1. Positive for breast cancer
Radiation 11/2014 with xeloda then weekly cisplatin
11/14 brain MRI clean
12/14 finished 33 radiations burnt and very painful. Bedridden for 1 week
12/14 t current Herceptin and perjeta only
02/15 rash on upper back right side skin mets radiation planned
02/15 staring electron radiation *35
Stopped at 30 due to severe skin burn, resumed 10 days later
05/15 red patches appeared in between previously radiated area, skin mets. Ct and brain Mri clear. Simulation planned, radiation to start after trip to Alaska.
05/24 new spot identified in scar line on previously radiated reconstructed breast- electron on both side chest wall area and scar line
07/15 multiple skin and lung recurrence begin halaven
11/15 cough much better but very tired on halaven and starting to see some new red skin blotches-suspicious
11/15 heading to China for immune therapy
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04-18-2012, 08:58 PM
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#3
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Senior Member
Join Date: Oct 2011
Location: Geelong, Australia
Posts: 250
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Re: Breast cancer mets to Uterus
I'm sorry I can't help you Greg, but welcome to the boards, I am sure more people, with more information will chime in soon. I think you are fantastic for looking for info. and advice on behalf of your wife
Best wishes
Dawn
__________________
Dx May 27 2011, age 43
Stage 1V 3.6cm breast lump, spot on lungs, nodes chest + neck
HER2+ ER/PR-
Abraxane weekly - 16 weeks
Herceptin every third week
September 26 2011 N.E.D!
Herceptin ongoing
8th Dec 2011 Brain MRI - clear
20th Dec 2011 bone/cat scan clear still NED
April 2012 scans show axillary node lump - ? what to do...
June 2012 Axillary node dissection 1/11 nodes affected, a wide local excision shows DCIS. Now what to do again? Watch and scan 3 monthly
April 2013, two spots in nodes to chest wall, start TDM1 (Kadcycla) as part of clinical trial
July 2013 stable
Oct 2013 progression off TDM-1 (Kadcycla)
Nov 2013 radiation to lymph nodes in sternum
Dec 2013. Mastectomy right side, pathology shows tumour was HER-2 negative, no wonder TDM-1 (Kadcycla) didn’t work!
April 2014 NED. On Herceptin only
August 2014 NED. On Herceptin only
March 2015. NED. On Herceptin only
September 2015 NED on Herceptin only
March 2016. Pulmonary embolism, Clexane injections daily forever. Still NED On Herceptin only
Nov 2016. Bone Mets in ribs - Radiation. Don’t know if bone Mets are er-/pr-/HER2+ or triple negative.
Can’t give self injections on to tablets (Xarelto) for blood clots.
2017 NED - On Herceptin only
2018 NED - On Herceptin only
2019 NED - On Herceptin only
2020 NED - On Herceptin only
2021 NED - On Herceptin only
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04-20-2012, 07:35 AM
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#4
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Senior Member
Join Date: Apr 2012
Posts: 87
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Re: Breast cancer mets to Uterus
Thank you for the comments.
__________________
08/10 ~ Dx IBC, Her2+++ ER-/PR- Stage 4, mets to liver. Age 43.
08/10 ~ Began 12 weeks of Taxetere/Carboplatin/Herceptin tx
[10/10 ~ Scans show liver lesions are gone. NED!
11/10 ~ Ended chemo. Herceptin-only tx
01/11 ~ Mastectomy
03/11 ~ Radiation
07/11 ~ Reconstructive surgery
10/11 ~ PET/CT shows NED :)
01/12 ~ Malignant tumors found in uterus, cervix, fallopian tubes and lymph nodes. Dx as endometrial cancer. Stage III2c
02/12 ~Hysterectomy(all tumors removed). Back to NED.
02/12 ~ Final Herceptin treatment.
03/12 ~ Began Cisplatin/Adriamycin tx for endometrial cancer.
03/12 ~ Tumors dx her2 metastisis, not entdometrial cancer. Back to BC tx.
03/12 ~ CT scan shows NED. :)
04/12/~ Began Tykerb/Xeloda.
06/12 ~ Ended Xeloda. Continuing Tykerb. Still NED.
09/12 ~ PET/CT scans show NED. : )
04/13 ~ Rash on original breast biopsied as cancer.
05/13 ~ Surgery to remove skin and tissue around rash. Continue Tykerb.
06/13 ~ PET/CT scans show NED : )
11/13 ~ Jaundice eyes and skin. CT scan show mets to liver as well as peritoneal carcinomatosis with malignant ascites. Began Abraxane/Herceptin tx.
02/14 ~ CT scan shows NED. :)
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04-21-2012, 06:31 PM
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#5
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Senior Member
Join Date: Oct 2007
Posts: 1,851
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Re: Breast cancer mets to Uterus
I know somebody with this diagnosis and will ask about her treatment.
Are the mets HER2+. I noticed that your wife has discontinued Herceptin. I heard Cliff Hudis from Memorial Sloan Kettering say many, many times recently that Herceptin is a remarkable drug because even if a woman advances while taking a particular chemo, she still does better if she stays on Herceptin if the mets are HER2+.
Joan
__________________
Diagnosed stage 2b in July 2003 (2.3 cm, HER2+, ER-/PR-, 7+ nodes). Treated with mastectomy (with immediate DIEP flap reconstruction), AC + T/Herceptin (off label). Cancer advanced to lung in Jan. 2007 (1 cm nodule). Started Herceptin every 3 weeks. Lung wedge resection April 2007. Cancer recurred in lung April 2008. RFA of lung in August 2008. 2nd annual brain MRI in Oct. 2008 discovered 2.6 cm cystic tumor in left frontal lobe. Craniotomy Oct. 2008 (ER-/PR-/HER2-) followed by targeted radiation (IMRT). Coughing up blood Feb. 2009. Thoractomy July 2009 to cut out fungal ball of common soil fungus (aspergillus) that grew in the RFA cavity (most likely inhaled while gardening). No cancer, only fungus. Removal of tiny melanoma from upper left arm, plus sentinel lymph node biopsy in Feb. 2016. Guardant Health liquid biopsy in Feb. 2016 showed mutations in 4 subtypes of TP53. Repeat of Guardant Health biopsy in Jana. 2021 showed 3 TP53 mutations, BRCA1 mutation and CHEK2 mutation. Invitae genetic testing showed negative for all of these. Living with MBC since 2007. Stopped Herceptin Hylecta (injection) treatment in March 2020. Recent 2023 annual CT of chest, abdomen and pelvis and annual brain MRI showed NED. Praying for NED forever!!
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04-22-2012, 01:34 PM
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#6
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Senior Member
Join Date: Jan 2008
Location: "Love never fails."
Posts: 5,808
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Re: Breast cancer mets to Uterus
Hi Greg,
Both Herceptin and Tykerb are medicine for Her2 breast cancer. Tykerb is a much smaller molecule and the pathway is somewhat different from Herceptin. That's why many long-term fighters have switched back and forth of the two drugs at different times.
The chance for a cure is much better now that the doctors know what they are dealing with.
Sending prayers and warm thoughts.
__________________
Jackie07
http://www.kevinmd.com/blog/2011/06/doctors-letter-patient-newly-diagnosed-cancer.html
http://www.asco.org/ASCOv2/MultiMedi...=114&trackID=2
NICU 4.4 LB
Erythema Nodosum 85
Life-long Central Neurocytoma 4x5x6.5 cm 23 hrs 62090 semi-coma 10 d PT OT ST 30 d
3 Infertility tmts 99 > 3 u. fibroids > Pills
CN 3 GKRS 52301
IDC 1.2 cm Her2 +++ ER 5% R. Lmptmy SLNB+1 71703 6 FEC 33 R Tamoxifen
Recc IIB 2.5 cm Bi-L Mast 61407 2/9 nds PET
6 TCH Cellulitis - Lymphedema - compression sleeve & glove
H w x 4 MUGA 51 D, J 49 M
Diastasis recti
Tamoxifen B. scan
Irrtbl bowel 1'09
Colonoscopy 313
BRCA1 V1247I
hptc hemangioma
Vertigo
GI - > yogurt
hysterectomy/oophorectomy 011410
Exemestane 25 mg tab 102912 ~ 101016 stopped due to r. hip/l.thigh pain after long walk
DEXA 1/13
1-2016 lesions in liver largest 9mm & 1.3 cm onco. says not cancer.
3-11 Appendectomy - visually O.K., a lot of puss. Final path result - not cancer.
Start Vitamin D3 and Calcium supplement （600mg x2)
10-10 Stopped Exemestane due to r. hip/l.thigh pain OKed by Onco 11-08-2016
7-23-2018 9 mm groundglass nodule within the right lower lobe with indolent behavior. Due to possible adenocarcinoma, Recommend annual surveilence.
7-10-2019 CT to check lung nodule.
1-10-2020 8mm stable nodule on R Lung, two 6mm new ones on L Lung, a possible lymph node involvement in inter fissule.
"I WANT TO BE AN OUTRAGEOUS OLD WOMAN WHO NEVER GETS CALLED AN OLD LADY. I WANT TO GET SHARP EDGED & EARTH COLORED, TILL I FADE AWAY FROM PURE JOY." Irene from Tampa
Advocacy is a passion .. not a pastime - Joe
Last edited by Jackie07; 04-22-2012 at 01:36 PM..
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04-22-2012, 02:37 PM
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#7
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Senior Member
Join Date: Apr 2011
Posts: 403
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Re: Breast cancer mets to Uterus
Hi Greg. I think your wife's oncologist is unlikely to add herceptin back in the treatment for now as she is on a new combo tykerb and xeloda. We need to give time for the drug to work, one or two months usually. If she responds well to the new drug she will be on it as long as it works; if it does not work then it's time to consider new treatment plan including adding herceptin back in treatment. Meanwhile she will be monitored via scans and tumor marker testing. There is another drug for her2 girls that may get approved this year Pertuzumab. Also tdm1 trial has shown promising results. The battle with cancer needs patience yet we all know its a race against time. The combo your wife is on is easier than taxane and adriamycin and she won't lose her hair. I have been on it for almost 2 weeks now and have seen improvements in my skin mets. It's a great drug and I hope your wife will benefit from it as well! I am sorry the PET scan didn't pick up the tumors. How did she find out about the tumors?
__________________
1/11 age 36 DX
ER/PR-, Her2 +
TCH*6, Herceptin
BMX with immediate recontruction 5/2011 Lattismus Flap- Dx stage 3c 10/23 nodes
9/11 Radiation
3/12 Local recurrence to skin stage IV
Whole body scan CLEAR
4/12 Tykerb & Xeolda Skin mets slowly regressing
8/12 PET & Brain CT Clear
5/13 Skin mets progressing
6/13 PET scan chestwall recurrence in contralateral anxillary,internal mammary and ipsilateral subpectoral nodes
6/13 kadcyla
10/13 whole body scan -clear NED. previously resolved skin rash gone but 3 new lesions. Biopsy confirmed for skin recurrence
11/13 to 02/14 tykerb & herceptin
02/14 add abraxane/gemzar, 2 weeks on 1 week off at reduced dose
05/14 whole body PET clear/ brain CT clear but skin mets are getting worse, ready for new chemo
05/14 navelbine perjeta herceptin
07/14 skin mets progressing red rash worse
08/14 wide local excision with diep flap to close wound. Final path shows 2 positive margins showing inflammatory carcinoma Going back to surgery in 2 weeks
09/01/14 resection- clear margins
3 weeks after 2nd surgery, a new nodular rash found near drain incision with 2 small red spots behind the chest wall biopsy on 10/1. Positive for breast cancer
Radiation 11/2014 with xeloda then weekly cisplatin
11/14 brain MRI clean
12/14 finished 33 radiations burnt and very painful. Bedridden for 1 week
12/14 t current Herceptin and perjeta only
02/15 rash on upper back right side skin mets radiation planned
02/15 staring electron radiation *35
Stopped at 30 due to severe skin burn, resumed 10 days later
05/15 red patches appeared in between previously radiated area, skin mets. Ct and brain Mri clear. Simulation planned, radiation to start after trip to Alaska.
05/24 new spot identified in scar line on previously radiated reconstructed breast- electron on both side chest wall area and scar line
07/15 multiple skin and lung recurrence begin halaven
11/15 cough much better but very tired on halaven and starting to see some new red skin blotches-suspicious
11/15 heading to China for immune therapy
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04-22-2012, 04:56 PM
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#8
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Senior Member
Join Date: Apr 2012
Posts: 87
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Re: Breast cancer mets to Uterus
We are hoping for Tykerb/Xeloda to be effective. I hate the feeling of ever running out of options. I'm curious as to why they would try again with Herceptin later since it didn't continue to do it's job the first time. Is that because it might work better when combined with other drugs?
The tumors were discovered after I had to drive her to the emergency room due to excessive menstrual bleeding. After that incident, we were referred to a GYN surgeon who performed biopsies. They were determined to be cancer so he performed a hysterectomy. That's when they made the initial incorrect diagnosis of endometrial cancer. It was only after our oncologist reached out to an oncologist at Johns Hopkins who suggested the tumors to be tested to rule out a spread of breast cancer. Unfortunately, she lost a good bit of hair due to the Cisplatin/Adriamycin. I'm hoping it will slow down now that she is only on Tykerb/Xeloda. She really does not like losing her hair!
Thanks,
Greg
__________________
08/10 ~ Dx IBC, Her2+++ ER-/PR- Stage 4, mets to liver. Age 43.
08/10 ~ Began 12 weeks of Taxetere/Carboplatin/Herceptin tx
[10/10 ~ Scans show liver lesions are gone. NED!
11/10 ~ Ended chemo. Herceptin-only tx
01/11 ~ Mastectomy
03/11 ~ Radiation
07/11 ~ Reconstructive surgery
10/11 ~ PET/CT shows NED :)
01/12 ~ Malignant tumors found in uterus, cervix, fallopian tubes and lymph nodes. Dx as endometrial cancer. Stage III2c
02/12 ~Hysterectomy(all tumors removed). Back to NED.
02/12 ~ Final Herceptin treatment.
03/12 ~ Began Cisplatin/Adriamycin tx for endometrial cancer.
03/12 ~ Tumors dx her2 metastisis, not entdometrial cancer. Back to BC tx.
03/12 ~ CT scan shows NED. :)
04/12/~ Began Tykerb/Xeloda.
06/12 ~ Ended Xeloda. Continuing Tykerb. Still NED.
09/12 ~ PET/CT scans show NED. : )
04/13 ~ Rash on original breast biopsied as cancer.
05/13 ~ Surgery to remove skin and tissue around rash. Continue Tykerb.
06/13 ~ PET/CT scans show NED : )
11/13 ~ Jaundice eyes and skin. CT scan show mets to liver as well as peritoneal carcinomatosis with malignant ascites. Began Abraxane/Herceptin tx.
02/14 ~ CT scan shows NED. :)
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04-22-2012, 10:14 PM
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#9
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Senior Member
Join Date: Jul 2011
Location: Melbourne, Australia
Posts: 432
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Re: Breast cancer mets to Uterus
As Herceptin is a targeted therapy it may well be that the chemo is the drug that has become ineffective (my theory - maybe the resident tech gurus will chime in here) and that still blocking the Her2 receptor is useful in trying with a different combination/chemotherapy. Lani posted a great article which shows this although questions the economics of doing so.
If you look at the Stage4 survivors thread there are many, many, many women there some 10 years down the track who have used multiple chemos with herceptin with positive effect.
I am currently on Tykerb and Xeloda and experiencing a positive response so far - no other chemo combination has reduced my mets but this one has some of them gone in 9 weeks!
Your wife has many, many options. Given that she has had the hysterectomy are the tumours now gone? Were they retested for receptor status?
I too was resistant to anthracyclines but am responding to Tykerb and xeloda - I hope that your wife does too.
__________________
Amanda xx
40 year old Mum to three gorgeous kids - son 5 and daughters 8 and 11
Wife to my wonderfully supportive husband of 17 years!
22 February 2011 - Diagnosed Early Breast Cancer IDBC Stage2b (ER/PR -ve, Her2+ve +++) - 38 years old
(L) skin sparing mastectomy with tissue expander, axilla clearance (2/14 affected) clear margins.
Fec*3, Taxotere and herceptin*2 - stopped due to secondary diagnosis
June 24 2011 Stage IV - Skin met, axilla node, multiple lung lesions
Bolero3 trial - Navelbine, Hereptin weekly, daily Everolimus/Placebo
February 2012 - July 2012 Tykerb and Xeloda - skin mets resolved, Lungs initially dramatically reduced but growing again
August 2012 (turn 40!) tykerb and herceptin (denied compassionate use of TDM1) while holidaying in Italy!
September 2012 - January 2013 TDM1 as part of the Th3resa trial - lymph nodes resolved, lungs slowly progressing.
January 2013 - herceptin, carboplatin and Perjeta (compassionate access)
April 2013 - Some progression in lungs and lymph nodes - Abraxane, Herceptin and Perjeta
July 2013 - mixed response - dramatic reduction of most lung disease, progression of smaller lung nodules and cervical and hilar nodes - ? Add avastin.
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04-22-2012, 11:06 PM
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#10
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Senior Member
Join Date: Apr 2011
Posts: 403
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Re: Breast cancer mets to Uterus
The science behind how each cell responds to drugs is yet an unsolved mystery because even if the majority respond to drug A, the minority may respond to drug B only or drug A+B. This explains why the same drug can tame lung mets but not liver mets. Each patient is different so we keep trying different drugs that work for us.
__________________
1/11 age 36 DX
ER/PR-, Her2 +
TCH*6, Herceptin
BMX with immediate recontruction 5/2011 Lattismus Flap- Dx stage 3c 10/23 nodes
9/11 Radiation
3/12 Local recurrence to skin stage IV
Whole body scan CLEAR
4/12 Tykerb & Xeolda Skin mets slowly regressing
8/12 PET & Brain CT Clear
5/13 Skin mets progressing
6/13 PET scan chestwall recurrence in contralateral anxillary,internal mammary and ipsilateral subpectoral nodes
6/13 kadcyla
10/13 whole body scan -clear NED. previously resolved skin rash gone but 3 new lesions. Biopsy confirmed for skin recurrence
11/13 to 02/14 tykerb & herceptin
02/14 add abraxane/gemzar, 2 weeks on 1 week off at reduced dose
05/14 whole body PET clear/ brain CT clear but skin mets are getting worse, ready for new chemo
05/14 navelbine perjeta herceptin
07/14 skin mets progressing red rash worse
08/14 wide local excision with diep flap to close wound. Final path shows 2 positive margins showing inflammatory carcinoma Going back to surgery in 2 weeks
09/01/14 resection- clear margins
3 weeks after 2nd surgery, a new nodular rash found near drain incision with 2 small red spots behind the chest wall biopsy on 10/1. Positive for breast cancer
Radiation 11/2014 with xeloda then weekly cisplatin
11/14 brain MRI clean
12/14 finished 33 radiations burnt and very painful. Bedridden for 1 week
12/14 t current Herceptin and perjeta only
02/15 rash on upper back right side skin mets radiation planned
02/15 staring electron radiation *35
Stopped at 30 due to severe skin burn, resumed 10 days later
05/15 red patches appeared in between previously radiated area, skin mets. Ct and brain Mri clear. Simulation planned, radiation to start after trip to Alaska.
05/24 new spot identified in scar line on previously radiated reconstructed breast- electron on both side chest wall area and scar line
07/15 multiple skin and lung recurrence begin halaven
11/15 cough much better but very tired on halaven and starting to see some new red skin blotches-suspicious
11/15 heading to China for immune therapy
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04-23-2012, 12:51 AM
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#11
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Senior Member
Join Date: Feb 2008
Location: South East Wisconsin
Posts: 3,431
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Re: Breast cancer mets to Uterus
It may be useful to think of Herceptin as a synergizer with whatever other treatment is being pursued. Over some years, there seems to be plenty of suggestion of benefit from continuation of Herceptin past "progression". Yes, a different paradigm from failed/abandoned drug concept. Plenty of patients take Herceptin along with Tykerb and Xeloda.
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04-26-2012, 04:17 PM
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#12
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Guest
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Re: Breast cancer mets to Uterus
I am responding at Joan request. I am not HER2 +but I do have a abnormal gene that may be causing the cancer not to follow a predictable pathway. I was originally diagnosed with bilateral breast cancer in 1997, followed by chemo and radiation and in 2001 the cancer metastasized to the cervix and is now on the walls of the vagina. I had a laproscopic hysterectomy followed by brachy therapy. I have taken several diffferent chemo pills, one being zelota and have been on an infused chemo for the past two years-navelbine, gemstar and currently taxol. Except for zelota, I have had no adverse reaction to any of the meds except some mild side effects from the taxol. To my knowledge there has been no research done on my particular cancer pathway.
Keep moving ahead.
S
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04-28-2012, 06:55 PM
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#13
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Senior Member
Join Date: May 2011
Location: Denver, CO
Posts: 1,427
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Re: Breast cancer mets to Uterus
I've read at least one recent study that said that, for some reason, combining chemos that quit working with Herceptin can be effective. So drug A can fail, drug B can fail, but A, B plus Herceptin can work.
__________________
Amy
_____________________________
4/19/11 Diagnosed invasive ductal carcinoma in left breast; 2.3 cm tumor, 1 axillary lymph node, weakly ER+, HER2+++
4/29/11 CT scan shows suspicious lesions on liver and lungs
5/17/11 liver biopsy
5/24/11 liver met confirmed--Stage IV at diagnosis
5/27/11 Begin weekly Taxol & Herceptin for 3 months (standard of care at the time of my DX)
7/18/11 Switch to weekly Abraxane & Herceptin due to Taxol allergy
8/29/11 CT scan shows no new lesions & old lesions shrinking
9/27/11 Finish Abraxane. Start Herceptin every 3 weeks. Begin taking Arimidex
10/17/11--Brain MRI--No Brain mets
12/5/11 PET scan--Almost NED
5/15/12 PET scan shows progression-breast/chest/spine (one vertebra)
5/22/12 Stop taking Arimidex; stay on Herceptin
6/11/12 Started Tykerb and Herceptin on clinical trial (w/no chemo)
9/24/12 CT scan--No new mets. Everything stable.
3/11/13 CT Scan--two small new possible mets and odd looking area in left lung getting larger.
4/2/13--Biopsy of suspicious area in lower left lung. Mets to lung confirmed.
4/30/13 Begin Kadcyla/TDM-1
8/16/13 PET scan "mixed," with some areas of increased uptake, but also some definite improvement, so I'll stay on TDM-1/Kadcyla.
11/11/13 Finally get hormone receptor results from lung biopsy of 4/2/13. My cancer is no longer ER positive.
11/13/13 PET scan mixed results again. We're calling it "stable." Problems breathing on exertion.
2/18/14 PET scan shows a new lesion and newly active lymph node in chest, other progression. Bye bye TDM-1.
2/28/14 Begin Herceptin/Perjeta every 3 weeks.
6/8/14 PET "mixed," with no new lesions, and everything but lower lungs improving. My breathing is better.
8/18/14 PET "mixed" again. Upper lungs & one spine met stable, lower lungs less FDG avid, original tumor more avid, one lymph node in mediastinum more avid.
9/1/14 Begin taking Xeloda one week on, one week off. Will also stay on Herceptin and Perjeta every three weeks.
12/11/14 PET Scan--no new lesions, and everything looks better than it did.
3/20/15 PET Scan--no new lesions, but lower lung lesions larger and a bit more avid.
4/13/15 Increasing Xeloda dose to 10 days on, one week off.
7/1/15 Scan "mixed" again, but suggests continuing progression. Stop Xeloda. Substitute Abraxane every 3 weeks starting 7/13.
10/28/15 PET scan shows dramatic improvement everywhere. All lesions except lower lungs have resolved; lower lungs noticeably improved.
12/18/15 Last Abraxane. Continue on Herceptin and Perjeta alone beginning 1/8/16.
1/27/16 PET scan shows cancer is stable.
5/11/16 PET scan shows uptake in some areas that were resolved on the last two scans.
6/3/16 Begin Kadcyla and Tykerb combination
6/5 - 6/23 Horrible diarrhea from K&T together. Got pneumonia.
7/15/16 Begin Kadcyla only every 3 weeks.
9/6/16 Begin radiation therapy on right lung lesion that caused the pneumonia.
10/3/16 Last of 12 radiation treatments to right lung.
11/4/16 Huffing and puffing, low O2, high heart rate, on tiniest bit of exertion. Diagnosed as radiation pneumonitis. Treated with Prednisone.
11/11/16 PET scan shows significant improvement to radiated part of right lung BUT a bunch of new lung lesions, and the bone met is getting worse.
11/22/16 Begin Eribulin and Herceptin. H every 3 weeks. E two weeks on, one week off.
3/6/17 Scan shows progression in lungs. Bone met a little better.
3/23/17 Lung biopsy. Tumor sampled is ER-, PR+ (5%), HER2+++. Getting Herceptin and Perjeta as a maintenance treatment.
5/31/17 Port placement
6/1/17 Start Navelbine & Tykerb
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04-28-2012, 07:25 PM
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#14
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Senior Member
Join Date: Apr 2012
Posts: 87
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Re: Breast cancer mets to Uterus
But, in my wife's case, Herceptin failed on its own. That's all she was on when her breast cancer spread to her uterus, cervix, fallopian tubes and lymph nodes. The Taxetere, Carboplatin with Herceptin did a great job taking care of the original mets to her liver. Why wouldn't Herceptin, by itself, be able to keep her breast cancer in check? There is no chemo drug failure to blame here.
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08/10 ~ Dx IBC, Her2+++ ER-/PR- Stage 4, mets to liver. Age 43.
08/10 ~ Began 12 weeks of Taxetere/Carboplatin/Herceptin tx
[10/10 ~ Scans show liver lesions are gone. NED!
11/10 ~ Ended chemo. Herceptin-only tx
01/11 ~ Mastectomy
03/11 ~ Radiation
07/11 ~ Reconstructive surgery
10/11 ~ PET/CT shows NED :)
01/12 ~ Malignant tumors found in uterus, cervix, fallopian tubes and lymph nodes. Dx as endometrial cancer. Stage III2c
02/12 ~Hysterectomy(all tumors removed). Back to NED.
02/12 ~ Final Herceptin treatment.
03/12 ~ Began Cisplatin/Adriamycin tx for endometrial cancer.
03/12 ~ Tumors dx her2 metastisis, not entdometrial cancer. Back to BC tx.
03/12 ~ CT scan shows NED. :)
04/12/~ Began Tykerb/Xeloda.
06/12 ~ Ended Xeloda. Continuing Tykerb. Still NED.
09/12 ~ PET/CT scans show NED. : )
04/13 ~ Rash on original breast biopsied as cancer.
05/13 ~ Surgery to remove skin and tissue around rash. Continue Tykerb.
06/13 ~ PET/CT scans show NED : )
11/13 ~ Jaundice eyes and skin. CT scan show mets to liver as well as peritoneal carcinomatosis with malignant ascites. Began Abraxane/Herceptin tx.
02/14 ~ CT scan shows NED. :)
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05-06-2012, 10:15 AM
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#15
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Senior Member
Join Date: Mar 2006
Posts: 4,778
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Re: Breast cancer mets to Uterus
You are missing the concepts of both synergism and of blocking multiple pathways of escape
A +B can work even if A or B alone do not
If you have a puppy who wants to escape the house and play in the backyard, locking the front door may not be enough. As it grows up and learns more it may escape out the back door. As it grows up even more and can jump it, it may jump on top of the dresser and hop out the open window.
Just because other chemos don't work, it doesn't mean that there aren't chemos to close other open windows. and reopening the front door but closing more windows definitely is not the best way.
her2 is the front door and herceptin has proven better than lapatinib in closing that front door so side windows of the front door don't open up soon. Closing the front door and its side windows is especially good. ie tykerb+herceptin
Hope this helps
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05-06-2012, 10:59 AM
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#16
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Senior Member
Join Date: Mar 2006
Posts: 4,778
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Re: Breast cancer mets to Uterus
MJs husband:
I went to entrez pubmed via google and put in breast cancer metastasis uterus and found a handful of papers back to 2006---stopped there there may be more
These usually involved lobular or signet ring histology of the initial breast cancer (one case metaplastic, though).
Was your wife's lobular or ductal? or one of the others?
Hope this helps
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