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Old 06-10-2011, 01:07 PM   #1
DeenaH
Senior Member
 
Join Date: Apr 2010
Posts: 129
Had lung surgery to have my tumors tested for chemo sensitivity

I had the surgery last Friday and got my results last night. Interestingly, my cancer showed resistance toward the next drug my doctors wanted me to try (Xeloda with Herceptin). Instead, it was very sensitive to Navelbine with Herceptin. Navelbine was second choice with my doctors. I have to say, this testing did change how I am going to manage my treatment. Only time will tell if the testing proves accurate, but I feel like I am at least making an educated guess. I plan to have another PET/CT 6 weeks after starting the treatment to see what it happening. I will be so interested to see the results of that scan! I had my surgery in Long Beach with Dr. Robert Shuman, and the testing was done by Rational Therapeutics and Dr. Robert Nagourney. They were able to get 3.7 grams of tumor (they typically need 1 gram), so they were able to test everything and the kitchen sink. The tumor tissue was taken across the street and was still attached to my lung tissue when tested, so it was very much still alive. The way Dr. Nagourney describes it is that they test the drugs before the cancer "wakes up and realizes it is outside the body". Also, the Navelbine + Herceptin actually killed the cancer with a very small dosage. I am praying that it works the same way inside my body!

Just thought I'd share my experience. I will be sure to post after my PET/CT to let you know the results.
__________________
March 2010: Diagnosed with Stage IIIC IDC with axillary, mammary and suplaclavicular node involvement. ER/PR -, HER2+++. 7cm tumor in right breast.
April 2010: Started neoadjuvent chemo. 4 DD A/C every 2 weeks, 4 DD Taxotere every 3 weeks with Herceptin weekly.
August 2010: Finished chemo!
August 20, 2010: PET/CT showed no cancer in any nodes, and only a little uptake to the breast.
September 9, 2010: Bilateral mastectomy with immediate reconstruction with implants and Alloderm.
September 16, 2010: Pathology report showed 18/51 positive axillary nodes, 3.2cm tumor. Granual sized cancer found in the fatty tissue between levels 1 and 2.
October 19, 2010: CT showed several spots on lungs and 1 spot on liver. Liver spot is 2mm, lung spots range from 2mm to 4mm. We don't know if they are cancer or not.
12/15/10: Brain MRI clear
1/7/11: PET/CT
1/13/11: Recurrence in lungs. Start Tykerb
5/13/11: Progression in lungs
6/3/11: Lung surgery to get tumors for chemosensitivity testing.
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