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Old 01-23-2007, 04:45 PM   #1
LAURIE
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confused about Fish results
I just got a copy of my biopsy FISH report today and am confused about what it said. I looked at the resources available on evaluating the report but am still confused. Maybe some of you all can help a little. Here is what I don't understand

Her-2/neu: CEF-17 ratio: 7,8:1
Average her-2/neu count per cell 15.6
Mamimum her-2/neu count per cell 22
Average CEP-17 count per cell: 2.0
Cells counted: 25

This resulted in a Positive/ Amplified Interpertation which is explained as Results> 2.2 with an average Her-2 signal count of 4>copies/cell, and [referably >7 copies/cell in a majority of scored nuclei.

In all these numbers does it relate to my Ki-67?
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Laurie
Diagonsed 8/10/06 (found own lump)at 35
Her 2 +++, er-/pr-
4 A/C 8-29-06 to 11-06
Lumpectomy, node dissection- 11/30/06
Pathology report stage IIIC
1 tumor 3 cm
10 of 15 nodes +
12 Taxol 12/18/06-03/06/07
Herceptin 12/18/06- 12/11/2007 done!!! yeah!!!
33 rads started 3/22/07, done!! yeah!! 5/07/07
Lymphedema diagonsed 2/1/07
BRCA1/BRCA2 negative
port out 1/10/08
pregnant after 6 yeas of trying- due mid feb.
Ryder David Kessel Hunter born feb.6th 2009
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Old 01-24-2007, 11:59 AM   #2
LAURIE
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anyone have ideas, was I not clear about what I was asking? I know I can ask my doc, but you all are like jello, fast, friendly and usually fail proof.
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Laurie
Diagonsed 8/10/06 (found own lump)at 35
Her 2 +++, er-/pr-
4 A/C 8-29-06 to 11-06
Lumpectomy, node dissection- 11/30/06
Pathology report stage IIIC
1 tumor 3 cm
10 of 15 nodes +
12 Taxol 12/18/06-03/06/07
Herceptin 12/18/06- 12/11/2007 done!!! yeah!!!
33 rads started 3/22/07, done!! yeah!! 5/07/07
Lymphedema diagonsed 2/1/07
BRCA1/BRCA2 negative
port out 1/10/08
pregnant after 6 yeas of trying- due mid feb.
Ryder David Kessel Hunter born feb.6th 2009
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Old 01-24-2007, 12:16 PM   #3
Chelee
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Laurie, Believe me...someone here will have an answer for you. Possible Becky or a few others I can think of. They are probably just busy at the moment...but when they check in I am sure you will get a few replies.

Hang in there...help is on the way.

Chelee
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DX: 12-20-05 - Stage IIIA, Her2/Neu, 3+++,Er & Pr weakly positive, 5 of 16 pos nodes.
Rt. MRM on 1-3-06 -- No Rads due to compromised lungs.
Chemo started 2-7-06 -- TCH - - Finished 6-12-06
Finished yr of wkly herceptin 3-19-07
3-15-07 Lt side prophylactic simple mastectomy. -- Ooph 4-05-07
9-21-09 PET/CT "Recurrence" to Rt. axllia, Rt. femur, ilium. Possible Sacrum & liver? Now stage IV.
9-28-09 Loading dose of Herceptin & started Zometa
9-29-09 Power Port Placement
10-24-09 Mass 6.4 x 4.7 cm on Rt. femur head.
11-19-09 RT. Femur surgery - Rod placed
12-7-09 Navelbine added to Herceptin/Zometa.
3-23-10 Ten days of rads to RT femur. Completed.
4-05-10 Quit Navelbine--Herceptin/Zometa alone.
5-4-10 Appt. with Dr. Slamon to see what is next? Waiting on FISH results from femur biopsy.
Results to FISH was unsuccessful--this happens less then 2% of the time.
7-7-10 Recurrence to RT axilla again. Back to UCLA for options.
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Old 01-24-2007, 12:35 PM   #4
skeetur
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Her-2/neu: CEF-17 ratio: 7,8:1
Average her-2/neu count per cell 15.6
Mamimum her-2/neu count per cell 22
Average CEP-17 count per cell: 2.0
Cells counted: 25

The way I read it... they evaluated 25 cancer cells. The average HER-2/neu count was 15.6 per cell. Divide your average HER-2 by the average CEP-17 gives you the ratio. 15.6/2.0 is 7.8. So your ratio is 7.8:1. Anything over 2 is an overexpression of HER-2. (The max HER-2 they saw on any one cell was 22.)

I do not know the relationship between this and the Ki-67 score.

Skeetur
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12/01/2006 Initial Dx via stereotactic biopsy - DCIS, grade 3
12/27/2006 Lumpectomy w/ SNB: 2 foci of IDC (largest .3 cm, Grade 2, Notthingham score 6) amid large area of DCIS: No clear margins on the DCIS; re-excision recommended
ER+(55%)/PR+(60+)/HER2+ (2.8+ via IHC?)
01/23/2007 Re-excision Lumpectomy: No clear margins on the DCIS; mastectomy recommended
03/02/2007 Bilateral mastectomy w/ expander implant insertion
03/19/2007 Emergency surgery to fix broken blood vessel in left breast
03/30/2007 Met w/ oncologist; oncologist checking on HER2 status with pathologist and doing some consulting on my case - no treatments for now!
05/02/2007 Next appointment w/ oncologist
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Old 01-25-2007, 07:10 AM   #5
CPA
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http://www.nccn.org/patients/fact_sheet.asp

Try this website. I think it might answer your questions.
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Husband to Jill
Diagnosed 10/05, age 39
R Mast 11/05
Stage II N0
Her2+ er/pr+
Revision Mast due to positive margins 12/05
TCH Chemo started 1/06
Finished TC 4/06
Tamoxifen
Finished H 12/29/06
Currently NED
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Old 01-25-2007, 09:43 AM   #6
Lani
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Ki67 is an entirely different marker
It is considered a marker of proliferation...so even within tumors with her2 amplification there are those which multiply faster than others.

Hope this helps!
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