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agness · 09-11-2015, 11:37 AM

Note that they are studying switching the order of treatment to radiation therapy first (SRS) and surgery second to see if they can help limit LM mets

"This Phase II trial will investigate the safety, tolerability, and effectiveness of changing the order of receiving radiation therapy for treating brain cancer and brain metastases. Normal procedure is to follow surgical removal of a brain metastases with stereotactic radio surgery. This trial reverses the order of these treatments in the hope that doing the radiation first will lower the risk of cancer spreading throughout the spinal fluid which covers the brain and spinal cord, causing leptomeningeal metastases. Patients with smaller brain metastases will start at a lower dose of radiation than those with larger brain metastases. To qualify for the trial patients must have brain metastases that can be removed by surgery. The metastases must be between 2 and 6 cm in size and no more than four in number."
Dose Escalation/De-escalation Study of Pre-operative Stereotactic Radiosurgery for Brain Metastases(RAD 1002)

https://clinicaltrials.gov/show/NCT01252797

09-11-2015, 11:37 AM	#9
agness Senior Member Join Date: Aug 2014 Location: Seattle, WA Posts: 285	Re: Compiling Data on HER2 Brain Mets Note that they are studying switching the order of treatment to radiation therapy first (SRS) and surgery second to see if they can help limit LM mets "This Phase II trial will investigate the safety, tolerability, and effectiveness of changing the order of receiving radiation therapy for treating brain cancer and brain metastases. Normal procedure is to follow surgical removal of a brain metastases with stereotactic radio surgery. This trial reverses the order of these treatments in the hope that doing the radiation first will lower the risk of cancer spreading throughout the spinal fluid which covers the brain and spinal cord, causing leptomeningeal metastases. Patients with smaller brain metastases will start at a lower dose of radiation than those with larger brain metastases. To qualify for the trial patients must have brain metastases that can be removed by surgery. The metastases must be between 2 and 6 cm in size and no more than four in number." Dose Escalation/De-escalation Study of Pre-operative Stereotactic Radiosurgery for Brain Metastases(RAD 1002) https://clinicaltrials.gov/show/NCT01252797 __________________ Dx 2/14 3b HER2+/HR- left breast, left axilla, internal mammary node (behind breast bone). Neoadjuvant TCHP 3/14-7/2. PCR 8/14 LX and SND. 10/21-12/9 Proton therapy to chest wall. Dx 7/20/15 cerebellar met 3.5x5cm HER2+/HR-/GATA3+ 7/23/15 Craniotomy. 7/29/15 bone scan clear. 8/3/15 PET clean scan. LINAC SRS (5 fractions) Sept 2015. 9/17/15 CSF NED, 9/24/15 CSF NED, 11/2/15 CSF NED. 10/27/15 atypical uptake in right cerebellum - inflammation? 12/1/15 Leptomeningeal dx. Starting IT Herceptin. 1/16 - 16 fractions of tomotherapy to cerebellum, break of IT Herceptin during rads, resume at 100 mg weekly 3/2016 - stable scan 5/2016 stable scan 7/2016 pseudoprogression? 9/2016 more LM, start new chemo protocol and IV therapy treatment with HBOT 11/2016 Cyberknife to temporal lobe, HBOT just prior 12/2016 - lesions starting to show shrinkage 8/2017 - Stable since Dec 2016. Temporal lobe lesion gone. Using TCM, naturopathic oncology, physical therapy, chiro, massage, medical qigong, and energetic healing modalities in tandem. Stops at nothing. Mother of 2 boys - ages 7 and 10 (8/2017) and a lovely partner with lots to live for.