[phil]

i agree with talking with your doc - have they treated other pts w/ t dm-1 ? if not encourage them to ask genentech . U must have had at least one set of scans by now ? scans are much more of a sure thing than mrkers. i have heard of markers going up at first on t dm-1 , my memory says for a few doses , i have heard possibly related to tdm-1 killing off cancer and dead cells in blood increasing . do u get a cea reading ?
are u her2 only ? those w/ er+ and her2 seem to get less effect from t dm-1, and may benefit from anti hormonal .
if we lived in a tx world that truly respected our stage iv rights , we could try perjeta too and see if mrkers fall. but not with our present fda in this country .