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Old 05-24-2014, 02:13 AM   #6
Senior Member
Join Date: Oct 2013
Posts: 402
Re: Tamoxifen Mechanism


Interesting. Don't forget Tamoxifen is not active but is a prodrug. The Enzyme CYP2D6 metabolizes Tamoxifen to the active drug, Nor Tamoxifen. CYP2D6 can be inhibited with drugs like Prozac, Paxil and Wellbutrin. (in generic terms-Fluoxetine, Paroxetine and Bupropion. These drugs can decrease the effect of Tamoxifen.

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