HER2 Support Group Forums - View Single Post - new targets being discovered for inflammatory bc

Lani · 02-13-2011, 06:24 PM

this article discusses techniques used to prove the necessity for certain genes/proteins/receptors to maintain growth and invasion of IBC

It also discusses which work in concert, which work as competitors

among the targets (the more specific the target, the less side-effects) are:

EGFR (FDA has already approved drugs)
Amphiregulin (a ligand rather than a receptor), aka AREG
DKK1
RHOB
networks associated with cell motility such as integrin-linked kinase signaling, and focal adhesion kinase signaling.
Wnt signalling
Notch signalling-- there are already trials of a gamma-secretase inhibitor in bc

Hope this helps!

02-13-2011, 06:24 PM	#4
Lani Senior Member Join Date: Mar 2006 Posts: 4,778	Re: new targets being discovered for inflammatory bc this article discusses techniques used to prove the necessity for certain genes/proteins/receptors to maintain growth and invasion of IBC It also discusses which work in concert, which work as competitors among the targets (the more specific the target, the less side-effects) are: EGFR (FDA has already approved drugs) Amphiregulin (a ligand rather than a receptor), aka AREG DKK1 RHOB networks associated with cell motility such as integrin-linked kinase signaling, and focal adhesion kinase signaling. Wnt signalling Notch signalling-- there are already trials of a gamma-secretase inhibitor in bc Hope this helps!