HER2 Support Group Forums - View Single Post - Genentech receives FDA approval for Kadcyla to treat HER2-positive metastatic breast

Mandamoo · 02-25-2013, 07:10 PM

So all patients who progress on the therapy are not included? I don't understand - I would have thought I for example would be included as a patient who was stable for 4months until disease progression?
As to you question, until they can tell who will we respond and who wouldn't I would be happy to take the risk - after all, 'they' tell me I'm going to die anyway so why not try something that may work? Not all would feel like this but I do, I would also go back on this drug in combination with something like Perjeta.

I don't thin tdm1 is game changing but am thankful that there is another option out there. I wonder when there might ever be something game changing - probably not in my lifetime. Until then I'm a lab rat living with some hope.

02-25-2013, 07:10 PM	#6
Mandamoo Senior Member Join Date: Jul 2011 Location: Melbourne, Australia Posts: 432	Re: Genentech receives FDA approval for Kadcyla to treat HER2-positive metastatic bre So all patients who progress on the therapy are not included? I don't understand - I would have thought I for example would be included as a patient who was stable for 4months until disease progression? As to you question, until they can tell who will we respond and who wouldn't I would be happy to take the risk - after all, 'they' tell me I'm going to die anyway so why not try something that may work? Not all would feel like this but I do, I would also go back on this drug in combination with something like Perjeta. I don't thin tdm1 is game changing but am thankful that there is another option out there. I wonder when there might ever be something game changing - probably not in my lifetime. Until then I'm a lab rat living with some hope. __________________ Amanda xx 40 year old Mum to three gorgeous kids - son 5 and daughters 8 and 11 Wife to my wonderfully supportive husband of 17 years! 22 February 2011 - Diagnosed Early Breast Cancer IDBC Stage2b (ER/PR -ve, Her2+ve +++) - 38 years old (L) skin sparing mastectomy with tissue expander, axilla clearance (2/14 affected) clear margins. Fec3, Taxotere and herceptin2 - stopped due to secondary diagnosis June 24 2011 Stage IV - Skin met, axilla node, multiple lung lesions Bolero3 trial - Navelbine, Hereptin weekly, daily Everolimus/Placebo February 2012 - July 2012 Tykerb and Xeloda - skin mets resolved, Lungs initially dramatically reduced but growing again August 2012 (turn 40!) tykerb and herceptin (denied compassionate use of TDM1) while holidaying in Italy! September 2012 - January 2013 TDM1 as part of the Th3resa trial - lymph nodes resolved, lungs slowly progressing. January 2013 - herceptin, carboplatin and Perjeta (compassionate access) April 2013 - Some progression in lungs and lymph nodes - Abraxane, Herceptin and Perjeta July 2013 - mixed response - dramatic reduction of most lung disease, progression of smaller lung nodules and cervical and hilar nodes - ? Add avastin.