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Old 02-07-2015, 06:27 PM   #4
Jackie07
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Re: When to test for tumor markers

I've seen/read several long-time stage IV sisters reporting in their signatures/postings changes of their tumor marker(s). A few would emphasize that their tumor marker had been very reliable. A lot of doctors take the same view as your doctor that it's not yet a tool for monitoring tumor progression. Below is the abstract of a recent article on the subject:

Curr Mol Pharmacol. 2015;7(1):4-21.
Targeted pathways in breast cancer: molecular and protein markers guiding therapeutic decisions.
Kourea HP, Zolota V, Scopa CD1.
Author information
Abstract
Breast carcinoma is currently considered as a group of diseases, differing not only in histopathologic phenotype, as indicated by histologic type and grade, but also in their protein, genetic and epigenetic molecular profile. The standard of care indicates that the core information for patient management includes data on Estrogen Receptor (ER), Progesterone Receptor (PgR) and Human Epidermal Growth Factor Receptor 2 (HER2), while there is an emerging role for the proliferation marker Ki67. These indices can be provided even in low resource settings and are indispensable for prognostication and therapeutic patient management. With the progress in molecular and translational research, there is a growing body of information on the molecular subtypes of breast carcinoma and their significance, and multigene signature assays are used to dictate prognosis and guide therapeutics in high resource settings. In addition, several cellular pathways involved in tumor growth and spread are dissected and targeted in clinical trials. Among these are the p53, RB, PI3K/Akt/mTOR and Ras/MAPK pathways, alterations associated with genetic instability and epigenetic alterations including histone methylation and acetylation, DNA methylation and microRNAs expression. The tumor immune microenvironment, including the tumor infiltrating lymphocytes (TILs) is attracting significant research interest. This review summarizes the mechanisms of function of the above factors in breast tumorigenesis with emphasis on their prognostic and predictive value and their use as therapeutic targets.
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Last edited by Jackie07; 02-07-2015 at 06:39 PM..
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