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Becky · 05-24-2013, 03:23 PM

Flori

Were you ever hormone positive? I am just thinking out loud here but hormone positive cancer just loves the bones. So, in thinking out loud, if Perjeta worked well on the highly her2+ cells, then what might be left behind are those that are hormone positive. Hence, they have lots of space to grow. What about testing out an AI or Faslodex shots (that cover the ER receptor) and see if there is an improvement (while staying on everything else you're on of course).

Just an idea. Something may have changed in the bones since ER+ cancer likes them best. If they were always alittle bit hormonal, there might not have been anything to shut them down so preferentially, they grew as Perjeta/Herceptin etc does nothing for that.

PS - this is would be an experiment but not a risky one and your onc might go along for a couple of months

05-24-2013, 03:23 PM	#8
Becky Senior Member Join Date: Sep 2005 Location: Stockton, NJ Posts: 4,179	Re: petscan good news bad news Flori Were you ever hormone positive? I am just thinking out loud here but hormone positive cancer just loves the bones. So, in thinking out loud, if Perjeta worked well on the highly her2+ cells, then what might be left behind are those that are hormone positive. Hence, they have lots of space to grow. What about testing out an AI or Faslodex shots (that cover the ER receptor) and see if there is an improvement (while staying on everything else you're on of course). Just an idea. Something may have changed in the bones since ER+ cancer likes them best. If they were always alittle bit hormonal, there might not have been anything to shut them down so preferentially, they grew as Perjeta/Herceptin etc does nothing for that. PS - this is would be an experiment but not a risky one and your onc might go along for a couple of months __________________ Kind regards Becky Found lump via BSE Diagnosed 8/04 at age 45 1.9cm tumor, ER+PR-, Her2 3+(rt side) 2 micromets to sentinel node Stage 2A left 3mm DCIS - low grade ER+PR+Her2 neg lumpectomies 9/7/04 4DD AC followed by 4 DD taxol Used Leukine instead of Neulasta 35 rads on right side only 4/05 started Tamoxifen Started Herceptin 4 months after last Taxol due to trial results and 2005 ASCO meeting & recommendations Oophorectomy 8/05 Started Arimidex 9/05 Finished Herceptin (16 months) 9/06 Arimidex Only Prolia every 6 months for osteopenia NED 18 years! Said Christopher Robin to Pooh: "You must remember this: You're braver than you believe and stronger than you seem and smarter than you think" Last edited by Becky; 05-24-2013 at 03:26 PM.. Reason: Add PS