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heblaj01 · 09-02-2006, 09:20 PM

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=15608670&dopt=Abstract

Cellular retinol-binding protein-I inhibits PI3K/Akt signaling through a retinoic acid receptor-dependent mechanism that regulates p85-p110 heterodimerization

I do not understand the possible implications of this research paper.
Does it mean that vitamin A (once converted into retinol in tissues) could inhibit PI3K/Akt & thus, among other things, reverse resistance to Herceptin?

Can someone shed some light?

I also noticed an article on high levels of retinol associated with lower risk of liver cancer.

09-02-2006, 09:20 PM	#1
heblaj01 Senior Member Join Date: Apr 2006 Posts: 543	Does vitamin A inhibit PI3K/Akt? http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=15608670&dopt=Abstract Cellular retinol-binding protein-I inhibits PI3K/Akt signaling through a retinoic acid receptor-dependent mechanism that regulates p85-p110 heterodimerization I do not understand the possible implications of this research paper. Does it mean that vitamin A (once converted into retinol in tissues) could inhibit PI3K/Akt & thus, among other things, reverse resistance to Herceptin? Can someone shed some light? I also noticed an article on high levels of retinol associated with lower risk of liver cancer.