HER2 Support Group Forums - View Single Post - breaking news from ASCO--new drug penetrates BBB , effectively combines w TDM1,is new

Lani · 06-01-2015, 11:10 PM

donocco--according to today's lecture on neratinib it is a tyrosine kinase inhibitor which irreversibly prevents phosphorylation of her1 2 and 4 (her 3 does not have an active intracellular domain which requires phosphorylation for activation as the other 3 her receptors do)

The worst side effect was diarrhea which caused some to discontinue use in the first 1-2 months, but they later found a workaround , a medication which resolved the diarrhea problems when taken regularly and discontinuations have fallen off.

THE RESULTS REPORTED SEEMS PHENOMENAL ESPECIALLY as they were even better for FOR ER+HER2+,.a group which traditionally experiences less pCRs from her2blockade with monoconal antibodies or their combinations with or without chemo.

06-01-2015, 11:10 PM	#9
Lani Senior Member Join Date: Mar 2006 Posts: 4,778	Re: breaking news from ASCO--new drug penetrates BBB , effectively combines w TDM1,is donocco--according to today's lecture on neratinib it is a tyrosine kinase inhibitor which irreversibly prevents phosphorylation of her1 2 and 4 (her 3 does not have an active intracellular domain which requires phosphorylation for activation as the other 3 her receptors do) The worst side effect was diarrhea which caused some to discontinue use in the first 1-2 months, but they later found a workaround , a medication which resolved the diarrhea problems when taken regularly and discontinuations have fallen off. THE RESULTS REPORTED SEEMS PHENOMENAL ESPECIALLY as they were even better for FOR ER+HER2+,.a group which traditionally experiences less pCRs from her2blockade with monoconal antibodies or their combinations with or without chemo.