HER2 Support Group Forums - View Single Post - Copper - Some interesting thoughts on copper toxicity

R.B. · 07-22-2010, 02:02 AM

I have only performed a couple of quick searches but it appears that excess copper may have a role in BC and other cancers. Reading on other topics like fertility suggests that a number of people suffer from high copper levels.

http://breast-cancer-research.com/content/7/6/R897
Clioquinol and pyrrolidine dithiocarbamate complex with copper to form proteasome inhibitors and apoptosis inducers in human breast cancer cells

"A physiological feature of many tumor tissues and cells is the tendency to accumulate high concentrations of copper. While the precise role of copper in tumors is cryptic, copper, but not other trace metals, is required for angiogenesis."

"Copper is an essential trace metal for animals. The amount of copper in an organism is tightly regulated [1,2]. Angiogenesis, the growth of a tumor blood supply, is essential for tumor growth, invasion, and metastasis [3-6]. It has been shown that tumors, without a blood supply, do not grow larger than 1 to 2 mm3 [7]. Molecular processes of angiogenesis that require copper as an essential cofactor include stimulation of endothelial growth by tumor cytokine production (i.e., vasoendothelial growth factor), degradation of extracellular matrix proteins by metalloproteinases, and migration of endothelial cells mediated by integrins [3-12]. Consistently high levels of copper have been found in many types of human cancers, including breast, prostate, colon, lung, and brain [13-21]. "

07-22-2010, 02:02 AM	#2
R.B. Senior Member Join Date: Mar 2006 Posts: 1,843	Re: Copper - Some interesting thoughts on copper toxicity I have only performed a couple of quick searches but it appears that excess copper may have a role in BC and other cancers. Reading on other topics like fertility suggests that a number of people suffer from high copper levels. http://breast-cancer-research.com/content/7/6/R897 Clioquinol and pyrrolidine dithiocarbamate complex with copper to form proteasome inhibitors and apoptosis inducers in human breast cancer cells "A physiological feature of many tumor tissues and cells is the tendency to accumulate high concentrations of copper. While the precise role of copper in tumors is cryptic, copper, but not other trace metals, is required for angiogenesis." "Copper is an essential trace metal for animals. The amount of copper in an organism is tightly regulated [1,2]. Angiogenesis, the growth of a tumor blood supply, is essential for tumor growth, invasion, and metastasis [3-6]. It has been shown that tumors, without a blood supply, do not grow larger than 1 to 2 mm3 [7]. Molecular processes of angiogenesis that require copper as an essential cofactor include stimulation of endothelial growth by tumor cytokine production (i.e., vasoendothelial growth factor), degradation of extracellular matrix proteins by metalloproteinases, and migration of endothelial cells mediated by integrins [3-12]. Consistently high levels of copper have been found in many types of human cancers, including breast, prostate, colon, lung, and brain [13-21]. "