HER2 Support Group Forums - View Single Post - Genentech receives FDA approval for Kadcyla to treat HER2-positive metastatic breast

Mandamoo · 02-25-2013, 06:16 PM

I was "bumped" off trial for disease progression - that's part of the deal - are you suggesting that my progression was not included (I was on the trial 4months? The trial criteria for progression is 25% growth in target tumor from its smallest size during trial. I was scanned every 6 weeks and asked for an earlier scan near the end of the trial as my previous scan had been questionable. While the treatment didn't work for me it drastically slowed the progression of my disease during the time I was on the drug - not good enough
I am not sure what you are suggesting with your post gdpawel? It remains that this is a very effective drug for some people - should they be denied the option because it is not effective for others?

02-25-2013, 06:16 PM	#4
Mandamoo Senior Member Join Date: Jul 2011 Location: Melbourne, Australia Posts: 432	Re: Genentech receives FDA approval for Kadcyla to treat HER2-positive metastatic bre I was "bumped" off trial for disease progression - that's part of the deal - are you suggesting that my progression was not included (I was on the trial 4months? The trial criteria for progression is 25% growth in target tumor from its smallest size during trial. I was scanned every 6 weeks and asked for an earlier scan near the end of the trial as my previous scan had been questionable. While the treatment didn't work for me it drastically slowed the progression of my disease during the time I was on the drug - not good enough I am not sure what you are suggesting with your post gdpawel? It remains that this is a very effective drug for some people - should they be denied the option because it is not effective for others? __________________ Amanda xx 40 year old Mum to three gorgeous kids - son 5 and daughters 8 and 11 Wife to my wonderfully supportive husband of 17 years! 22 February 2011 - Diagnosed Early Breast Cancer IDBC Stage2b (ER/PR -ve, Her2+ve +++) - 38 years old (L) skin sparing mastectomy with tissue expander, axilla clearance (2/14 affected) clear margins. Fec3, Taxotere and herceptin2 - stopped due to secondary diagnosis June 24 2011 Stage IV - Skin met, axilla node, multiple lung lesions Bolero3 trial - Navelbine, Hereptin weekly, daily Everolimus/Placebo February 2012 - July 2012 Tykerb and Xeloda - skin mets resolved, Lungs initially dramatically reduced but growing again August 2012 (turn 40!) tykerb and herceptin (denied compassionate use of TDM1) while holidaying in Italy! September 2012 - January 2013 TDM1 as part of the Th3resa trial - lymph nodes resolved, lungs slowly progressing. January 2013 - herceptin, carboplatin and Perjeta (compassionate access) April 2013 - Some progression in lungs and lymph nodes - Abraxane, Herceptin and Perjeta July 2013 - mixed response - dramatic reduction of most lung disease, progression of smaller lung nodules and cervical and hilar nodes - ? Add avastin.