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agness · 10-06-2015, 03:20 AM

"there is initial evidence that penetration of trastuzumab into CSF may be facilitated under conditions of an impaired BBB, as is known for meningeal carcinomatosis. We demonstrate further that high levels of trastuzumab can also be achieved by direct application of trastuzumab into the brain using an Ommaya reservoir. Given the increasing use of trastuzumab to treat HER2-overexpressing breast cancer patients in the metastatic and the adjuvant setting, more patients are expected to benefit from this therapy and may experience a considerable survival advantage."

Application of intrathecal trastuzumab (HerceptinTM) for treatment of meningeal carcinomatosis in HER2-overexpressing metastatic breast cancer (2005)
http://www.spandidos-publications.co.../1373/download

10-06-2015, 03:20 AM	#24
agness Senior Member Join Date: Aug 2014 Location: Seattle, WA Posts: 285	Re: Compiling Data on HER2 Brain Mets "there is initial evidence that penetration of trastuzumab into CSF may be facilitated under conditions of an impaired BBB, as is known for meningeal carcinomatosis. We demonstrate further that high levels of trastuzumab can also be achieved by direct application of trastuzumab into the brain using an Ommaya reservoir. Given the increasing use of trastuzumab to treat HER2-overexpressing breast cancer patients in the metastatic and the adjuvant setting, more patients are expected to benefit from this therapy and may experience a considerable survival advantage." Application of intrathecal trastuzumab (HerceptinTM) for treatment of meningeal carcinomatosis in HER2-overexpressing metastatic breast cancer (2005) http://www.spandidos-publications.co.../1373/download __________________ Dx 2/14 3b HER2+/HR- left breast, left axilla, internal mammary node (behind breast bone). Neoadjuvant TCHP 3/14-7/2. PCR 8/14 LX and SND. 10/21-12/9 Proton therapy to chest wall. Dx 7/20/15 cerebellar met 3.5x5cm HER2+/HR-/GATA3+ 7/23/15 Craniotomy. 7/29/15 bone scan clear. 8/3/15 PET clean scan. LINAC SRS (5 fractions) Sept 2015. 9/17/15 CSF NED, 9/24/15 CSF NED, 11/2/15 CSF NED. 10/27/15 atypical uptake in right cerebellum - inflammation? 12/1/15 Leptomeningeal dx. Starting IT Herceptin. 1/16 - 16 fractions of tomotherapy to cerebellum, break of IT Herceptin during rads, resume at 100 mg weekly 3/2016 - stable scan 5/2016 stable scan 7/2016 pseudoprogression? 9/2016 more LM, start new chemo protocol and IV therapy treatment with HBOT 11/2016 Cyberknife to temporal lobe, HBOT just prior 12/2016 - lesions starting to show shrinkage 8/2017 - Stable since Dec 2016. Temporal lobe lesion gone. Using TCM, naturopathic oncology, physical therapy, chiro, massage, medical qigong, and energetic healing modalities in tandem. Stops at nothing. Mother of 2 boys - ages 7 and 10 (8/2017) and a lovely partner with lots to live for.