HER2 Support Group Forums - View Single Post - Anyone on HERCEPTIN+AROMATASE INHIBITORS?

heblaj01 · 06-23-2006, 12:01 PM

Robin has posted a very interesting article at http://www.her2support.org/vbulletin/showthread.php?t=24319

In it the researchers describe,among other things, two of the modes of action of Herceptin.
The attaching of Herceptin to the HER protein on the surface of cancer cells & the destruction of this protein is a relatively slow process while the activation of the PTEN (which control cell division) starts within 10 minutes. PTEN also appears necessary for Herceptin to be effective in any case.
So if a patient starts with a high level of PTEN it no only predicts that she likely will respond to Herceptin but also that she may respond very quickly.
This adds an other possible factor which may explain the fast response of some posters in this thread.

06-23-2006, 12:01 PM	#24
heblaj01 Senior Member Join Date: Apr 2006 Posts: 543	PTEN as a factor of fast response to Herceptin Robin has posted a very interesting article at http://www.her2support.org/vbulletin/showthread.php?t=24319 In it the researchers describe,among other things, two of the modes of action of Herceptin. The attaching of Herceptin to the HER protein on the surface of cancer cells & the destruction of this protein is a relatively slow process while the activation of the PTEN (which control cell division) starts within 10 minutes. PTEN also appears necessary for Herceptin to be effective in any case. So if a patient starts with a high level of PTEN it no only predicts that she likely will respond to Herceptin but also that she may respond very quickly. This adds an other possible factor which may explain the fast response of some posters in this thread.