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agness · 10-06-2015, 02:23 AM

In the overall population (n = 186), median PFS was 18.7 weeks in patients with BM and 19.4 weeks in patients without BM (HR 0.98 [95% CI: 0.71-1.35], P = 0.88). Among patients with BM, median overall PFS was significantly prolonged in patients who did not use prior capecitabine (28.3 weeks vs 14.0 weeks, P = 0.009), but brain PFS was not statistically significantly different between these two subsets (31.4 weeks vs 25.6 weeks, P = 0.54; Figure 1).

Clinical outcomes of HER2-positive metastatic breast cancer patients with brain metastasis treated with lapatinib and capecitabine: an open-label expanded access study in Korea
http://www.biomedcentral.com/1471-2407/12/322

10-06-2015, 02:23 AM	#21
agness Senior Member Join Date: Aug 2014 Location: Seattle, WA Posts: 285	Re: Compiling Data on HER2 Brain Mets In the overall population (n = 186), median PFS was 18.7 weeks in patients with BM and 19.4 weeks in patients without BM (HR 0.98 [95% CI: 0.71-1.35], P = 0.88). Among patients with BM, median overall PFS was significantly prolonged in patients who did not use prior capecitabine (28.3 weeks vs 14.0 weeks, P = 0.009), but brain PFS was not statistically significantly different between these two subsets (31.4 weeks vs 25.6 weeks, P = 0.54; Figure 1). Clinical outcomes of HER2-positive metastatic breast cancer patients with brain metastasis treated with lapatinib and capecitabine: an open-label expanded access study in Korea http://www.biomedcentral.com/1471-2407/12/322 __________________ Dx 2/14 3b HER2+/HR- left breast, left axilla, internal mammary node (behind breast bone). Neoadjuvant TCHP 3/14-7/2. PCR 8/14 LX and SND. 10/21-12/9 Proton therapy to chest wall. Dx 7/20/15 cerebellar met 3.5x5cm HER2+/HR-/GATA3+ 7/23/15 Craniotomy. 7/29/15 bone scan clear. 8/3/15 PET clean scan. LINAC SRS (5 fractions) Sept 2015. 9/17/15 CSF NED, 9/24/15 CSF NED, 11/2/15 CSF NED. 10/27/15 atypical uptake in right cerebellum - inflammation? 12/1/15 Leptomeningeal dx. Starting IT Herceptin. 1/16 - 16 fractions of tomotherapy to cerebellum, break of IT Herceptin during rads, resume at 100 mg weekly 3/2016 - stable scan 5/2016 stable scan 7/2016 pseudoprogression? 9/2016 more LM, start new chemo protocol and IV therapy treatment with HBOT 11/2016 Cyberknife to temporal lobe, HBOT just prior 12/2016 - lesions starting to show shrinkage 8/2017 - Stable since Dec 2016. Temporal lobe lesion gone. Using TCM, naturopathic oncology, physical therapy, chiro, massage, medical qigong, and energetic healing modalities in tandem. Stops at nothing. Mother of 2 boys - ages 7 and 10 (8/2017) and a lovely partner with lots to live for.