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Old 04-01-2010, 04:32 PM   #2
Rich66
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Join Date: Feb 2008
Location: South East Wisconsin
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Re: Review Paper on Signaling Pathways; Her2+ and ER+ discussed

Yep..onco-alphabet soup.

This concluding statement resembled English:


Quote:
Currently, monotherapies that target the receptor or ERK1/2 activity are predicted to be of limited value. Instead, combination therapies that target growth factor receptors, multiple signalling pathways and signalling targets point the way forward [83,84]; an example of this would be an EGFR/ErbB2 inhibitor plus a multi-signalling pathway inhibitor (for example, the Ras farensyltransferase inhibitor, which blocks ERK1/2 activation and mTor (mammalian target of rapamycin) signals (or a Src inhibitor [182]) plus a ‘full oestrogen antagonist’ (for example, fulvestrant)). Rapid development of successful strategies in this area is keenly awaited.
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