Discussion
Compared with Herceptin, Curcumin had wide range of cytotocicity across Her-2 overexpressed and non-Her2 overexpressed breast cancer cell lines. Curcumin not only effective in the herceptin sensitve BT-484, but also exert its effect against the herceptin resistant SKBr-3(hr) cells
In this preliminary study, curcumin could reduce the cell viability of various breast cancer cell lines. The effectiveness of curcumin in the treatment of Her-2 overexpressed breast cance was illustrated in vitro BT-474 and SKBr-3(hr) cell lines and in vivo BT-474 xenograft model
Curcumin had comparable ability to inhibit cell proliferation, anti-mobility/mestastasis, anti-angiogenesis ability as herceptin and the potential to overcome herceptin resistance.
