HER2 Support Group Forums - View Single Post - Iodine deficiency ! - falling intakes - goitregens

R.B. · 10-26-2013, 02:13 AM

Going back to the core issue of this board breast cancer.

There seems to be no easily findable (if any?) work looking at the effect of fluoride or perchlorate intake on breast cancer risk.

There is more work looking at iodine and breast cancer; but not a lot. This paper on iodine is interesting.

Odd bits of research, much of it old (I guess because funding for iodine research is limited - it cannot be patented) strongly suggest it is likely that iodine transporters are not the only mechanisms for the uptake of iodide / iodine so the whole issue of iodine probably has many more layers than we are currently aware of.

Interestingly and in a way unsurprisingly (babies need iodine) the hormones associated with pregnancy and lactation increase iodine transporter activity. A high proportion of breast cancers demonstrate increased iodine uptake; the question is how does low iodine affect the early and later development of BC. The abstract below suggest that iodine is preventative, and that many of those with BC are deficient in iodine and or have enlarged thyroids etc (low iodine is in general terms linked with increase in thyroid size it appears).

Iodine Alters Gene Expression in the MCF7 Breast Cancer Cell Line: Evidence for an Anti-Estrogen Effect of Iodine

http://www.medsci.org/v05p0189.htm

The high rate of breast disease in women with thyroid abnormalities (both dietary and clinical) suggests a correlation between thyroid and breast physiology [1-3]. In addition, women with breast cancer have larger thyroid volumes then controls [2]. Multiple studies suggest that abnormalities in iodine metabolism are the likely link [4-7]. Additionally, the impact of iodine therapy for the maintenance of healthy breast tissue has been reported in both animal [4-7] and clinical studies [8, 9] yet the mechanisms responsible remain unclear.

Iodide (I-) uptake is observed in approximately 80% of breast cancers as well as fibrocystic breast disease and lactating breasts; however, quantitatively, no significant iodide uptake is reported in normal, non-lactating breast tissue [10]. Clinical trials have demonstrated that women with cyclic mastalgia [9] or fibrocystic disease [8] can have symptomatic relief from treatment with molecular iodine (I2). Iodine deficiency, either dietary or pharmacologic, can lead to breast atypia and increased incidence of malignancy in animal models [11]. Furthermore, iodine treatment can reverse dysplasia which results from iodine deficiency [5]. Rat models using N-methyl-N-nitrosourea (NMU) and dimethyl-benz[a]anthracene (DMBA) to induce dysplasia and eventually carcinogenesis have shown that the presence of molecular iodine in the animal's diet can prevent tumor formation; yet, when iodine is removed from the diet, these animals develop tumors at rates comparable to those of control animals [5, 7]. These data suggest that iodine diminishes early cancer progression through an inhibitory effect on cancer initiating cells. . .

10-26-2013, 02:13 AM	#37
R.B. Senior Member Join Date: Mar 2006 Posts: 1,843	Re: Iodine deficiency ! - falling intakes - goitregens - competition bromine and fluo Going back to the core issue of this board breast cancer. There seems to be no easily findable (if any?) work looking at the effect of fluoride or perchlorate intake on breast cancer risk. There is more work looking at iodine and breast cancer; but not a lot. This paper on iodine is interesting. Odd bits of research, much of it old (I guess because funding for iodine research is limited - it cannot be patented) strongly suggest it is likely that iodine transporters are not the only mechanisms for the uptake of iodide / iodine so the whole issue of iodine probably has many more layers than we are currently aware of. Interestingly and in a way unsurprisingly (babies need iodine) the hormones associated with pregnancy and lactation increase iodine transporter activity. A high proportion of breast cancers demonstrate increased iodine uptake; the question is how does low iodine affect the early and later development of BC. The abstract below suggest that iodine is preventative, and that many of those with BC are deficient in iodine and or have enlarged thyroids etc (low iodine is in general terms linked with increase in thyroid size it appears). Iodine Alters Gene Expression in the MCF7 Breast Cancer Cell Line: Evidence for an Anti-Estrogen Effect of Iodine http://www.medsci.org/v05p0189.htm The high rate of breast disease in women with thyroid abnormalities (both dietary and clinical) suggests a correlation between thyroid and breast physiology [1-3]. In addition, women with breast cancer have larger thyroid volumes then controls [2]. Multiple studies suggest that abnormalities in iodine metabolism are the likely link [4-7]. Additionally, the impact of iodine therapy for the maintenance of healthy breast tissue has been reported in both animal [4-7] and clinical studies [8, 9] yet the mechanisms responsible remain unclear. Iodide (I-) uptake is observed in approximately 80% of breast cancers as well as fibrocystic breast disease and lactating breasts; however, quantitatively, no significant iodide uptake is reported in normal, non-lactating breast tissue [10]. Clinical trials have demonstrated that women with cyclic mastalgia [9] or fibrocystic disease [8] can have symptomatic relief from treatment with molecular iodine (I2). Iodine deficiency, either dietary or pharmacologic, can lead to breast atypia and increased incidence of malignancy in animal models [11]. Furthermore, iodine treatment can reverse dysplasia which results from iodine deficiency [5]. Rat models using N-methyl-N-nitrosourea (NMU) and dimethyl-benz[a]anthracene (DMBA) to induce dysplasia and eventually carcinogenesis have shown that the presence of molecular iodine in the animal's diet can prevent tumor formation; yet, when iodine is removed from the diet, these animals develop tumors at rates comparable to those of control animals [5, 7]. These data suggest that iodine diminishes early cancer progression through an inhibitory effect on cancer initiating cells. . . Last edited by R.B.; 10-26-2013 at 02:35 AM..