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agness · 09-11-2015, 10:24 AM

My neuro-oncologist shared the ASCO 2011 Graded Prognostic Assessment for Brain Metastasis that includes breast cancer and breaks out HER2 positivity (no differentiation between hormonal status though).

The 2011 report used an original dataset spanned 1985-2007, so it predates Perjeta and some other more current treatments, plus some HER2 patients didn't receive Herceptin until it was made publicly available.

ASCO Graded Prognostic Assessment for Brain Metastases [Journal of Clinical Oncology, January 2012]
http://jco.ascopubs.org/content/30/4/419.full
Figure 1 includes the scoring table, midway are the patient characteristics. I scored 90-100 for KPS but you might need to consult with your oncologist about what that is for you; it has to do with functioning level versus impairments. You see which column your diagnosis falls into and then you use the prognositc factor to the right under the patient score (0,.5,1.0,1.5,2.0) to see what your final total and then there is a key at the bottom of the table for median survival.

This recent report on HER2 Brain mets using the above validates this scoring method.
Graded prognostic assessment (GPA) of HER2 positive breast cancer patients with brain metastases. [2015]
http://meetinglibrary.asco.org/content/145612-156

09-11-2015, 10:24 AM	#2
agness Senior Member Join Date: Aug 2014 Location: Seattle, WA Posts: 285	Re: Compiling Data on HER2 Brain Mets My neuro-oncologist shared the ASCO 2011 Graded Prognostic Assessment for Brain Metastasis that includes breast cancer and breaks out HER2 positivity (no differentiation between hormonal status though). The 2011 report used an original dataset spanned 1985-2007, so it predates Perjeta and some other more current treatments, plus some HER2 patients didn't receive Herceptin until it was made publicly available. ASCO Graded Prognostic Assessment for Brain Metastases [Journal of Clinical Oncology, January 2012] http://jco.ascopubs.org/content/30/4/419.full Figure 1 includes the scoring table, midway are the patient characteristics. I scored 90-100 for KPS but you might need to consult with your oncologist about what that is for you; it has to do with functioning level versus impairments. You see which column your diagnosis falls into and then you use the prognositc factor to the right under the patient score (0,.5,1.0,1.5,2.0) to see what your final total and then there is a key at the bottom of the table for median survival. This recent report on HER2 Brain mets using the above validates this scoring method. Graded prognostic assessment (GPA) of HER2 positive breast cancer patients with brain metastases. [2015] http://meetinglibrary.asco.org/content/145612-156 __________________ Dx 2/14 3b HER2+/HR- left breast, left axilla, internal mammary node (behind breast bone). Neoadjuvant TCHP 3/14-7/2. PCR 8/14 LX and SND. 10/21-12/9 Proton therapy to chest wall. Dx 7/20/15 cerebellar met 3.5x5cm HER2+/HR-/GATA3+ 7/23/15 Craniotomy. 7/29/15 bone scan clear. 8/3/15 PET clean scan. LINAC SRS (5 fractions) Sept 2015. 9/17/15 CSF NED, 9/24/15 CSF NED, 11/2/15 CSF NED. 10/27/15 atypical uptake in right cerebellum - inflammation? 12/1/15 Leptomeningeal dx. Starting IT Herceptin. 1/16 - 16 fractions of tomotherapy to cerebellum, break of IT Herceptin during rads, resume at 100 mg weekly 3/2016 - stable scan 5/2016 stable scan 7/2016 pseudoprogression? 9/2016 more LM, start new chemo protocol and IV therapy treatment with HBOT 11/2016 Cyberknife to temporal lobe, HBOT just prior 12/2016 - lesions starting to show shrinkage 8/2017 - Stable since Dec 2016. Temporal lobe lesion gone. Using TCM, naturopathic oncology, physical therapy, chiro, massage, medical qigong, and energetic healing modalities in tandem. Stops at nothing. Mother of 2 boys - ages 7 and 10 (8/2017) and a lovely partner with lots to live for.