[Lani]

If you look again at my MUST READ thread, it and scores and scores of other studies show the value of the continuation of herceptin beyond progression ie, it is not that herceptin is not effective, but that another pathway needs to be blocked in addition. Most experts in the field concur that few cancers will be cured with single agent orchestrated lethality, but rather with the combination of a few targeted therapies ie, let's imagine a combination like herceptin+pertumab+ tykerb + anti Estrogen agent if necessary. or herceptin+mTor inhibitor+HSP inhibitor etc.

In those cases where a particularly overwhelming driving mutation or fusion protein is found, monotherapy may be appropriate, but those will probably be the vast minority of cases.

I will post an article/link from today's NYT to illustrate that concept(has to do with leukemia, but principle is the same)