HER2 Support Group Forums - View Single Post - Could use some prayers...I so need a break

Rich66 · 05-08-2012, 08:55 AM

Maybe worth a look:

Cancer Biol Ther. 2012 May 1;13(7). [Epub ahead of print]
Activity of pegylated liposomal doxorubicin in combination with gemcitabine in triple negative breast cancer with skin involvement: Two case reports.

Franchina T, Adamo B, Ricciardi GP, Caristi N, Agostino RM, Proto C, Adamo V.

LINK

Source

Unit of Integrated Therapies in Oncology; Department of Human Pathology; University Policlinic; G Martino, Italy.

Abstract

Breast carcinoma (BC) is a heterogeneous disease in terms of histology, therapeutic response, dissemination patterns to distant sites and patient outcomes. Triple-negative breast cancer (TNBC), defined by the lack of protein expression of estrogen and progesterone receptors and the absence of HER2 protein overexpression (ER-/PR-/HER2-) has significant clinical implications due to their poor prognosis and the lack of targeted agents. Skin involvement is one of the most distressing presentations of locally recurrent breast cancer and few studies have identified effective agents in this setting. In fact, the increasing use of anthracycline/taxane-based chemotherapy in the neoadjuvant and/or adjuvant settings has led to investigate new cytotoxic therapies such as the combination of pegylated liposomal doxorubicin (PLD) with gemcitabine. Here, we report two cases of disseminated TNBC with extensive cutaneous metastases and a remarkable response to PLD in combination with gemcitabine. Further investigations are needed to confirm the efficacy of this regimen in skin involvement and TNBC.

PMID:22526226 [PubMed - as supplied by publisher]

05-08-2012, 08:55 AM	#43
Rich66 Senior Member Join Date: Feb 2008 Location: South East Wisconsin Posts: 3,431	Re: Could use some prayers...I so need a break Maybe worth a look: Cancer Biol Ther. 2012 May 1;13(7). [Epub ahead of print] Activity of pegylated liposomal doxorubicin in combination with gemcitabine in triple negative breast cancer with skin involvement: Two case reports. Franchina T, Adamo B, Ricciardi GP, Caristi N, Agostino RM, Proto C, Adamo V. LINK Source Unit of Integrated Therapies in Oncology; Department of Human Pathology; University Policlinic; G Martino, Italy. Abstract Breast carcinoma (BC) is a heterogeneous disease in terms of histology, therapeutic response, dissemination patterns to distant sites and patient outcomes. Triple-negative breast cancer (TNBC), defined by the lack of protein expression of estrogen and progesterone receptors and the absence of HER2 protein overexpression (ER-/PR-/HER2-) has significant clinical implications due to their poor prognosis and the lack of targeted agents. Skin involvement is one of the most distressing presentations of locally recurrent breast cancer and few studies have identified effective agents in this setting. In fact, the increasing use of anthracycline/taxane-based chemotherapy in the neoadjuvant and/or adjuvant settings has led to investigate new cytotoxic therapies such as the combination of pegylated liposomal doxorubicin (PLD) with gemcitabine. Here, we report two cases of disseminated TNBC with extensive cutaneous metastases and a remarkable response to PLD in combination with gemcitabine. Further investigations are needed to confirm the efficacy of this regimen in skin involvement and TNBC. PMID:22526226 [PubMed - as supplied by publisher]