[Rich66]

"They found that long-term use of the drugs -- at least four years -- was associated with an increase in the buckling ratio, reflecting a higher risk for fracture."

Ok...how much higher? Makes a difference in cancer world where benefit A is weighed against risk B.


"They looked at bone biopsies taken from the thigh bones of 21 women, all past menopause, who had suffered fractures at the site. Nine had not taken the drugs, while 12 had, for an average of 8.5 years."

So half had fractures w/o bisphosphonates? Same type of fractures? Same amount of osteoporosis at diagnosis? I suspect those who were on bisphosphonates had higher levels of osteoporosis to start with.

And it's unclear whether those on drugs took supplements or not.